ID F7W992_SORMK Unreviewed; 1157 AA.
AC F7W992;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=DNA mismatch repair protein {ECO:0000256|PIRNR:PIRNR037677};
GN Name=putative msh3 {ECO:0000313|EMBL:CCC05172.1};
GN ORFNames=SMAC_08039 {ECO:0000313|EMBL:CCC05172.1};
OS Sordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Sordaria.
OX NCBI_TaxID=771870 {ECO:0000313|EMBL:CCC05172.1, ECO:0000313|Proteomes:UP000001881};
RN [1] {ECO:0000313|EMBL:CCC05172.1, ECO:0000313|Proteomes:UP000001881}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-333 / DSM 997 / K(L3346) / K-hell
RC {ECO:0000313|Proteomes:UP000001881};
RC TISSUE=Mycelium {ECO:0000313|EMBL:CCC05172.1};
RX PubMed=20386741; DOI=10.1371/journal.pgen.1000891;
RA Nowrousian M., Stajich J., Chu M., Engh I., Espagne E., Halliday K.,
RA Kamerewerd J., Kempken F., Knab B., Kuo H.C., Osiewacz H.D., Poeggeler S.,
RA Read N., Seiler S., Smith K., Zickler D., Kueck U., Freitag M.;
RT "De novo assembly of a 40 Mb eukaryotic genome from short sequence reads:
RT Sordaria macrospora, a model organism for fungal morphogenesis.";
RL PLoS Genet. 6:E1000891-E1000891(2010).
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family. MSH3
CC subfamily. {ECO:0000256|ARBA:ARBA00007094}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCC05172.1}.
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DR EMBL; CABT02000050; CCC05172.1; -; Genomic_DNA.
DR RefSeq; XP_003347472.1; XM_003347424.1.
DR AlphaFoldDB; F7W992; -.
DR STRING; 771870.F7W992; -.
DR GeneID; 10804925; -.
DR KEGG; smp:SMAC_08039; -.
DR VEuPathDB; FungiDB:SMAC_08039; -.
DR eggNOG; KOG0218; Eukaryota.
DR HOGENOM; CLU_002472_0_0_1; -.
DR InParanoid; F7W992; -.
DR OMA; HIAPCEL; -.
DR OrthoDB; 168255at2759; -.
DR Proteomes; UP000001881; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF122; DNA MISMATCH REPAIR PROTEIN MSH3; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 2.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR037677};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|PIRNR:PIRNR037677};
KW DNA repair {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR037677};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR037677}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001881}.
FT DOMAIN 959..975
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 1..191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1034..1066
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..49
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..85
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 86..110
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 117..162
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 163..177
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1043..1066
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1157 AA; 126435 MW; A5310760BC4CF625 CRC64;
MAGPSRPPEK KQASISSFFT PRNTSPLVNL SQNATKKAPP ATESKPSKPS TSSTRKRPEP
PKDDDESEDD APRGAKRRKS NGPSSATKDT EDAVASLTLS SSSRTERYAL NASRPFQDGE
ENEEDAAERK KKEELHRKFV KKLGHPDSMF NYRRRDTESA AAAEGEGGED GEDDAEEEPA
PKAATKKKGA KTGKLTPMEL QFLEIKRKHM DTLLIVEVGY KFRFFGEDAR IAARELSIVC
IPGKFRYDEH PSEAHLDRFA SASIPVHRLP VHVKRLVAAG HKVGVVRQIE TAALKKAGDN
RNAPFVRKLT NVYTKGTYID ETGELDQPGE TTGASSGGYL LCLTETPAKG MGTDEKVNVG
IIAVQPATGD IIYDEFEDGF MRREIETRLL HISPCEFLIV GDLSKATDKL IQHLSGSSTN
VFGDKSRVER IPKSKTMAAE AYSHVTDFYA GKAKDSDERS AALLDKVLKL PEAVIICLSA
MIIHLTEYGL QHIFGLTKYF QSFSTRQHML INGTTLESLE VYRNATDHSE KGSLLWALDK
THTRFGQRLL RKWIGRPLLD QQRLEERVSA VEELLNNQST AKVDKLVGML KSIKADLERS
LIRIYYGKCT RPELLSTLQT LQKISLEYAR VISPSDTGFA SPLLTSAIMT LPSISPIVTA
HLSKINAEAA RKDDKYAFFL EQHETDAISE HKLGIAAVEQ DLDEHRSEAA KELGKKVPVN
YVTVAGIEYL IEVANTDLKR VPASWAKISG TKKVSRFHTP TVLRLIAERD QHKESLASAC
DQAFADLLAQ IAGEYQPLRD AVSSLSTLDC LLSLSTVAAS PGYSKPTFLP SSHPSFLSIT
EGRHPIAEHL LPNGYIPFTM SLGTPSSSSS SSSGSISAQA QLITGPNMGG KSSYVRAVAL
LVLLAQIGSF VPATCMTLTL SDAIFTRMGA RDNLFKGEST FMVEVSETAS ILRQATPRSL
VVLDELGRGT STHDGAAIAG AVLEYVARDV GCLMLFITHY QDLARVAEGI VLDEEVQGKK
IRAVDCVHMR FASNKGPKGE EADDDDDGGD IMEVDGAEGE GDGDRADEDE EITFLYDLAP
GVAHRSYGLN VARLARIPRK VLEVAAKKSR ELEEVVRARR VKGAVGLLGD VLKGDGSRSG
DDDGEKLEQL LGLVEQL
//
