ID F7WB18_SORMK Unreviewed; 702 AA.
AC F7WB18;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=ATP-dependent DNA helicase {ECO:0000256|RuleBase:RU363044};
DE EC=3.6.4.12 {ECO:0000256|RuleBase:RU363044};
GN ORFNames=SMAC_12620 {ECO:0000313|EMBL:CCC05406.1};
OS Sordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Sordaria.
OX NCBI_TaxID=771870 {ECO:0000313|EMBL:CCC05406.1, ECO:0000313|Proteomes:UP000001881};
RN [1] {ECO:0000313|EMBL:CCC05406.1, ECO:0000313|Proteomes:UP000001881}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-333 / DSM 997 / K(L3346) / K-hell
RC {ECO:0000313|Proteomes:UP000001881};
RC TISSUE=Mycelium {ECO:0000313|EMBL:CCC05406.1};
RX PubMed=20386741; DOI=10.1371/journal.pgen.1000891;
RA Nowrousian M., Stajich J., Chu M., Engh I., Espagne E., Halliday K.,
RA Kamerewerd J., Kempken F., Knab B., Kuo H.C., Osiewacz H.D., Poeggeler S.,
RA Read N., Seiler S., Smith K., Zickler D., Kueck U., Freitag M.;
RT "De novo assembly of a 40 Mb eukaryotic genome from short sequence reads:
RT Sordaria macrospora, a model organism for fungal morphogenesis.";
RL PLoS Genet. 6:E1000891-E1000891(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|RuleBase:RU363044};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|RuleBase:RU363044};
CC -!- SIMILARITY: Belongs to the helicase family.
CC {ECO:0000256|RuleBase:RU363044}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCC05406.1}.
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DR EMBL; CABT02000068; CCC05406.1; -; Genomic_DNA.
DR RefSeq; XP_003349197.1; XM_003349149.1.
DR AlphaFoldDB; F7WB18; -.
DR STRING; 771870.F7WB18; -.
DR GeneID; 10806684; -.
DR KEGG; smp:SMAC_12620; -.
DR VEuPathDB; FungiDB:SMAC_12620; -.
DR eggNOG; KOG0987; Eukaryota.
DR HOGENOM; CLU_001613_7_4_1; -.
DR InParanoid; F7WB18; -.
DR OMA; CIKTCKP; -.
DR OrthoDB; 5474774at2759; -.
DR Proteomes; UP000001881; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0000723; P:telomere maintenance; IEA:InterPro.
DR CDD; cd18809; SF1_C_RecD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR010285; DNA_helicase_pif1-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR049163; Pif1-like_2B_dom.
DR PANTHER; PTHR47642; ATP-DEPENDENT DNA HELICASE; 1.
DR PANTHER; PTHR47642:SF5; ATP-DEPENDENT DNA HELICASE; 1.
DR Pfam; PF05970; PIF1; 1.
DR Pfam; PF21530; Pif1_2B_dom; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU363044};
KW DNA damage {ECO:0000256|RuleBase:RU363044};
KW DNA recombination {ECO:0000256|RuleBase:RU363044};
KW DNA repair {ECO:0000256|RuleBase:RU363044};
KW Helicase {ECO:0000256|RuleBase:RU363044};
KW Hydrolase {ECO:0000256|RuleBase:RU363044};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU363044};
KW Reference proteome {ECO:0000313|Proteomes:UP000001881}.
FT DOMAIN 487..519
FT /note="DNA helicase Pif1-like 2B"
FT /evidence="ECO:0000259|Pfam:PF21530"
FT REGION 35..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 117..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 527..567
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 143..160
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 702 AA; 79169 MW; BF70F776855283E1 CRC64;
MRQNVWRLAG AFPVAHLNQS PRYSAWNPFI QKRNRNTTAE DRGKVGQPLD HNGRPLSEEA
ITAAREYWRL QEFIDHSLSP PTSGLLHEIH LHRTTYTNAV LNQDGASKVA ATRTYEPPYI
EPSRDNDELQ PNELPPLLDY HWHTYSSSPS SQSVDPSPEP GPSFSSEEDH PSLSPEQEAL
VELAASGDNI FYTGSAGSGK SRVLHAIKER LQGLGQVVHV VAPTGKAASN VSGMTTWSFA
GWSPGLTRQG INDLVGKSCS NIVRQRIIGT DVLIIDEISM VENLHFERLN AVFKRIRQNR
RPFGGAQVIV VGDFCQLPPV LPFKLCFKCG KQMKRVGCQD EETTTYTCKP CRETYTDADK
WVFRSKAWKQ CNFTNIHLKT IHRQHDPQFI SMLEKCRVGN RLTLEEVETL LYHPSNTEQG
TKLLPTRLEA RLLNEETFKN LPTQARSYQC YDEFRWQKKR HPELAYLNER RPDGTLEALK
DQVLEPTLHL KAGMSVVLLY NLSVYRGLYN GSQGEVIGFQ PFSYRSNAPK RPKRPKRPKR
PVSNPNVAPS REEMAQVKPS HAEGQDHDDD IIEWPVVQFA NGVTQLIHPI LRKIELGESE
PYSELMRIQI PLAPAWAMTI HKCQGMTMDR VIVDLSKAFV TGQAYVALSR ARSLAGLKVE
GSPRNLLSGM GMNETVRKFL NDTFGDEWTG GSLSKTSSVP WS
//
