ID F7XPG3_METZD Unreviewed; 660 AA.
AC F7XPG3;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Archaeal Rqc2 homolog aRqcH {ECO:0000256|HAMAP-Rule:MF_00844};
DE Short=aRqcH {ECO:0000256|HAMAP-Rule:MF_00844};
GN Name=rqcH {ECO:0000256|HAMAP-Rule:MF_00844};
GN OrderedLocusNames=Mzhil_0417 {ECO:0000313|EMBL:AEH60292.1};
OS Methanosalsum zhilinae (strain DSM 4017 / NBRC 107636 / OCM 62 / WeN5)
OS (Methanohalophilus zhilinae).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanosarcinales; Methanosarcinaceae; Methanosalsum.
OX NCBI_TaxID=679901 {ECO:0000313|EMBL:AEH60292.1, ECO:0000313|Proteomes:UP000006622};
RN [1] {ECO:0000313|EMBL:AEH60292.1, ECO:0000313|Proteomes:UP000006622}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 4017 / NBRC 107636 / OCM 62 / WeN5
RC {ECO:0000313|Proteomes:UP000006622};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K.,
RA Ovchinnikova G., Daligault H., Detter J.C., Han C., Tapia R., Larimer F.,
RA Land M., Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T.,
RA Wu D., Spring S., Schueler E., Brambilla E., Klenk H.-P., Eisen J.A.;
RT "The complete genome of Methanosalsum zhilinae DSM 4017.";
RL Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AEH60292.1, ECO:0000313|Proteomes:UP000006622}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 4017 / NBRC 107636 / OCM 62 / WeN5
RC {ECO:0000313|Proteomes:UP000006622};
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K.,
RA Ovchinnikova G., Daligault H., Detter J.C., Han C., Tapia R., Larimer F.,
RA Land M., Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T.,
RA Wu D., Spring S., Schueler E., Brambilla E., Klenk H.-P., Eisen J.A.;
RT "The complete genome of Methanosalsum zhilinae DSM 4017.";
RL Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Probably part of the ribosome quality control system (RQC).
CC May mediate the addition of alanine residues (Ala tailing) to
CC incompletely synthesized nascent chains from stalled ribosomes, leading
CC to their degradation. {ECO:0000256|HAMAP-Rule:MF_00844}.
CC -!- SUBUNIT: Associates with stalled 50S ribosomal subunits.
CC {ECO:0000256|HAMAP-Rule:MF_00844}.
CC -!- SIMILARITY: Belongs to the NEMF family. {ECO:0000256|HAMAP-
CC Rule:MF_00844}.
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DR EMBL; CP002101; AEH60292.1; -; Genomic_DNA.
DR RefSeq; WP_013897731.1; NC_015676.1.
DR AlphaFoldDB; F7XPG3; -.
DR STRING; 679901.Mzhil_0417; -.
DR GeneID; 10822022; -.
DR KEGG; mzh:Mzhil_0417; -.
DR HOGENOM; CLU_003612_2_1_2; -.
DR OrthoDB; 10943at2157; -.
DR Proteomes; UP000006622; Chromosome.
DR GO; GO:0043023; F:ribosomal large subunit binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0072344; P:rescue of stalled ribosome; IEA:UniProtKB-UniRule.
DR Gene3D; 2.30.310.10; ibrinogen binding protein from staphylococcus aureus domain; 1.
DR HAMAP; MF_00844_A; RqcH_A; 1.
DR InterPro; IPR008532; NFACT_RNA-bd.
DR InterPro; IPR043681; RqcH_archaeal.
DR NCBIfam; NF041120; RqcH_arch; 1.
DR PANTHER; PTHR15239; NUCLEAR EXPORT MEDIATOR FACTOR NEMF; 1.
DR PANTHER; PTHR15239:SF6; RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF; 1.
DR Pfam; PF05670; NFACT-R_1; 1.
DR Pfam; PF05833; NFACT_N; 1.
PE 3: Inferred from homology;
KW Protein biosynthesis {ECO:0000256|HAMAP-Rule:MF_00844};
KW Reference proteome {ECO:0000313|Proteomes:UP000006622};
KW RNA-binding {ECO:0000256|HAMAP-Rule:MF_00844};
KW tRNA-binding {ECO:0000256|HAMAP-Rule:MF_00844}.
FT DOMAIN 461..570
FT /note="NFACT RNA-binding"
FT /evidence="ECO:0000259|Pfam:PF05670"
SQ SEQUENCE 660 AA; 74777 MW; 945A74F9B58827F8 CRC64;
MKDEMSSADV SALVYELVHG PYNLIDAKIG KIYQPFSDEI RINLFIHGKG RDNLILEAGK
RAHISKNLPP NPKLPPSFPM LLRKHLSGGR ILDISQYDFD RIIEIRIVRG GVETVLVAEL
FARGNIVLLD SERKIILPMK PVTFRGRKIR SGETYEYPES KVNPLEITEE KMKDLLYTST
SDLVRTIATK MNLGGNLSEE ICLVSGIDKN RSAKEIDDQE ISILCESVND VLSPLVSGDL
KPNIVKKKND DLEPINVNPF DLKIFEKYEK EYYESFNEAL DEYFGKASLE KVDEKVETVK
KDKAGVFERR LQQQKTAISK FEKQAEKYVQ AAEKIYSYYQ DIEHITDALN NARSKGYSWS
EIKSIIKSSK DSTQAAKSII NIDPGKGIIV LDLDGTNVEI NINKSIPQNA EMYYEKAKKV
TRKRDGALKA LEETKASMQK KEKKEPSKRK IIRKPSWYER FRWFISSDGF LVVGGRDADT
NEEIVKKYME KRDLFFHTQA PGAPVTIIKT EGKEVPSTTI EEASRFVVSY SSLWKLGHFA
GDCYMVKPEQ VSKTPESGEY LKKGSFVIRG ERNYFKNVPM RVAVGIEKDT PRVIGGPVSA
ITKWGEHIIE LIPGKFNQND IAKKIYRILV DSVEDVSLVR QIASPDKIAR MLPPGGSDIV
//
