ID F7YW24_9THEM Unreviewed; 330 AA.
AC F7YW24;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=NAD-dependent epimerase/dehydratase {ECO:0000313|EMBL:AEH50511.1};
GN ORFNames=Theth_0416 {ECO:0000313|EMBL:AEH50511.1};
OS Pseudothermotoga thermarum DSM 5069.
OC Bacteria; Thermotogota; Thermotogae; Thermotogales; Thermotogaceae;
OC Pseudothermotoga.
OX NCBI_TaxID=688269 {ECO:0000313|EMBL:AEH50511.1, ECO:0000313|Proteomes:UP000006804};
RN [1] {ECO:0000313|EMBL:AEH50511.1, ECO:0000313|Proteomes:UP000006804}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 5069 {ECO:0000313|EMBL:AEH50511.1,
RC ECO:0000313|Proteomes:UP000006804};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Copeland A., Lapidus A., Bruce D., Goodwin L., Pitluck S.,
RA Kyrpides N., Mavromatis K., Ivanova N., Zeytun A., Brettin T., Detter J.C.,
RA Tapia R., Han C., Land M., Hauser L., Markowitz V., Cheng J.-F.,
RA Hugenholtz P., Woyke T., Wu D., Spring S., Schroeder M., Brambilla E.,
RA Klenk H.-P., Eisen J.A.;
RT "The complete genome of Thermotoga thermarum DSM 5069.";
RL Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC {ECO:0000256|ARBA:ARBA00009219}.
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DR EMBL; CP002351; AEH50511.1; -; Genomic_DNA.
DR RefSeq; WP_013931734.1; NC_015707.1.
DR AlphaFoldDB; F7YW24; -.
DR STRING; 688269.Theth_0416; -.
DR KEGG; tta:Theth_0416; -.
DR PATRIC; fig|688269.3.peg.428; -.
DR eggNOG; COG0451; Bacteria.
DR HOGENOM; CLU_007383_6_0_0; -.
DR OrthoDB; 9807212at2; -.
DR Proteomes; UP000006804; Chromosome.
DR GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR CDD; cd05228; AR_FR_like_1_SDR_e; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR Pfam; PF01073; 3Beta_HSD; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000006804}.
FT DOMAIN 3..219
FT /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF01073"
SQ SEQUENCE 330 AA; 36820 MW; 084B9E13C2B70822 CRC64;
MILVTGATGH LGNVLVRLLV VSNKKVRVLV LPNEDLKPLE DLNVEIVRGD VRDFEAVNKA
CKNVEVVYHL AAVISIFGKS KLVYEVNVEG TKNVLRACMK NRVSRMLYVS SVHAFAELAK
GSLIDENVPI DPKLVTGHYA KSKAMATQEV LKAVKEGFDA VLIFPTGIIG PYDWRLSEMG
SLIVYFCGGM LKLAVGGGFD FVDVRDVAKA MILALEKADR GEKFILSGEY VTIRALIEML
ERIVGKKPRV IFLPNWTAYL VAMAAIPYYK LKNQKPLLTF YSVFALSRGY IYSNQKARQK
LDFSPMPVFE SLKDAVDWFA ENGYVVTRSR
//
