GenomeNet

Database: UniProt
Entry: F8A4K3_CELGA
LinkDB: F8A4K3_CELGA
Original site: F8A4K3_CELGA 
ID   F8A4K3_CELGA            Unreviewed;       429 AA.
AC   F8A4K3;
DT   21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT   21-SEP-2011, sequence version 1.
DT   24-JAN-2024, entry version 44.
DE   RecName: Full=Multidrug efflux pump Tap {ECO:0000256|ARBA:ARBA00040914};
GN   OrderedLocusNames=Celgi_2753 {ECO:0000313|EMBL:AEI13251.1};
OS   Cellulomonas gilvus (strain ATCC 13127 / NRRL B-14078) (Cellvibrio gilvus).
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Cellulomonadaceae;
OC   Cellulomonas.
OX   NCBI_TaxID=593907 {ECO:0000313|EMBL:AEI13251.1, ECO:0000313|Proteomes:UP000000485};
RN   [1] {ECO:0000313|Proteomes:UP000000485}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 13127 / NRRL B-14078 {ECO:0000313|Proteomes:UP000000485};
RA   Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA   Peters L., Munk A., Detter J.C., Han C., Tapia R., Land M., Hauser L.,
RA   Kyrpides N., Ivanova N., Ovchinnikova G., Pagani I., Mead D., Brumm P.,
RA   Woyke T.;
RT   "Complete sequence of Cellvibrio gilvus ATCC 13127.";
RL   Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. Drug:H(+)
CC       antiporter-3 (DHA3) (TC 2.A.1.21) family.
CC       {ECO:0000256|ARBA:ARBA00038075}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP002665; AEI13251.1; -; Genomic_DNA.
DR   RefSeq; WP_013884768.1; NC_015671.1.
DR   AlphaFoldDB; F8A4K3; -.
DR   STRING; 593907.Celgi_2753; -.
DR   KEGG; cga:Celgi_2753; -.
DR   eggNOG; COG2814; Bacteria.
DR   HOGENOM; CLU_034180_13_0_11; -.
DR   OMA; SFIELVP; -.
DR   OrthoDB; 145388at2; -.
DR   Proteomes; UP000000485; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   CDD; cd06173; MFS_MefA_like; 1.
DR   Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   PANTHER; PTHR23513; INTEGRAL MEMBRANE EFFLUX PROTEIN-RELATED; 1.
DR   PANTHER; PTHR23513:SF6; MULTIDRUG EFFLUX PUMP TAP; 1.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000485};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        61..81
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        93..111
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        184..204
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        238..260
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        272..291
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        303..322
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        328..345
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        365..384
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        390..410
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          25..414
FT                   /note="Major facilitator superfamily (MFS) profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50850"
SQ   SEQUENCE   429 AA;  44110 MW;  19375C6655D0F1A8 CRC64;
     MTTTARAEQD TPVAGAPEQA ALGRRFHALL ATTGLANLGD GIVQMGAPLV ALTLTRSPGQ
     IALLAAATWL PWLVLGLVGG VVVDRTDRRT TQVVALIARA VLLAAGTWLA LTDALTMPSL
     VLLVLAYGVT EVFADLAQTS LVPDLVPRSR LQAANGRVLA VQQVTNTFVG SPLAGVMLAL
     GTGWVFGVPA AMAVVAVLVL LRGVPGRYRA GRTEKTAAVA DVREGIRYVV HHPVLRPFVI
     GGGLMNMAST AYFAVFVLWV VGPGSRMEMQ PAHFPLVTAV LAVGAVAGSL VTERLVARLP
     ELGVMYACWF AAVPLLLVPV LWPTVPALGA AVLLIGFTNT IGNTISQSLR QRIVPRALLG
     RTSGAGRTIA FGLMPVGALL GGVVAEHAGI AAVLVGSTVV AAAAAAYPLL TVSRATVAAA
     EPDGTAELA
//
DBGET integrated database retrieval system