ID F8ABQ5_THEID Unreviewed; 880 AA.
AC F8ABQ5;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Peptidase M16 domain protein {ECO:0000313|EMBL:AEH44507.1};
GN OrderedLocusNames=Thein_0626 {ECO:0000313|EMBL:AEH44507.1};
OS Thermodesulfatator indicus (strain DSM 15286 / JCM 11887 / CIR29812).
OC Bacteria; Thermodesulfobacteriota; Thermodesulfobacteria;
OC Thermodesulfobacteriales; Thermodesulfatatoraceae; Thermodesulfatator.
OX NCBI_TaxID=667014 {ECO:0000313|EMBL:AEH44507.1, ECO:0000313|Proteomes:UP000006793};
RN [1] {ECO:0000313|Proteomes:UP000006793}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15286 / JCM 11887 / CIR29812
RC {ECO:0000313|Proteomes:UP000006793};
RA Lucas S., Copeland A., Lapidus A., Bruce D., Goodwin L., Pitluck S.,
RA Peters L., Kyrpides N., Mavromatis K., Pagani I., Ivanova N., Saunders L.,
RA Detter J.C., Tapia R., Han C., Land M., Hauser L., Markowitz V.,
RA Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Spring S., Schroeder M.,
RA Brambilla E., Klenk H.-P., Eisen J.A.;
RT "The complete genome of Thermodesulfatator indicus DSM 15286.";
RL Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AEH44507.1, ECO:0000313|Proteomes:UP000006793}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15286 / JCM 11887 / CIR29812
RC {ECO:0000313|Proteomes:UP000006793};
RX PubMed=22768359; DOI=10.4056/sigs.2665915;
RA Anderson I., Saunders E., Lapidus A., Nolan M., Lucas S., Tice H.,
RA Del Rio T.G., Cheng J.F., Han C., Tapia R., Goodwin L.A., Pitluck S.,
RA Liolios K., Mavromatis K., Pagani I., Ivanova N., Mikhailova N., Pati A.,
RA Chen A., Palaniappan K., Land M., Hauser L., Jeffries C.D., Chang Y.J.,
RA Brambilla E.M., Rohde M., Spring S., Goker M., Detter J.C., Woyke T.,
RA Bristow J., Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C.,
RA Klenk H.P.;
RT "Complete genome sequence of the thermophilic sulfate-reducing ocean
RT bacterium Thermodesulfatator indicus type strain (CIR29812(T)).";
RL Stand. Genomic Sci. 6:155-164(2012).
CC -!- SIMILARITY: Belongs to the peptidase M16 family.
CC {ECO:0000256|ARBA:ARBA00007261, ECO:0000256|RuleBase:RU004447}.
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DR EMBL; CP002683; AEH44507.1; -; Genomic_DNA.
DR RefSeq; WP_013907252.1; NC_015681.1.
DR AlphaFoldDB; F8ABQ5; -.
DR STRING; 667014.Thein_0626; -.
DR PaxDb; 667014-Thein_0626; -.
DR KEGG; tid:Thein_0626; -.
DR eggNOG; COG0612; Bacteria.
DR HOGENOM; CLU_007487_1_0_0; -.
DR InParanoid; F8ABQ5; -.
DR OrthoDB; 9811314at2; -.
DR Proteomes; UP000006793; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR001431; Pept_M16_Zn_BS.
DR InterPro; IPR007863; Peptidase_M16_C.
DR PANTHER; PTHR11851; METALLOPROTEASE; 1.
DR PANTHER; PTHR11851:SF229; PEPTIDASE M16 DOMAIN PROTEIN; 1.
DR Pfam; PF00675; Peptidase_M16; 2.
DR Pfam; PF05193; Peptidase_M16_C; 2.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
DR PROSITE; PS00143; INSULINASE; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006793};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 751..774
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 42..185
FT /note="Peptidase M16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00675"
FT DOMAIN 194..367
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
FT DOMAIN 490..610
FT /note="Peptidase M16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00675"
FT DOMAIN 635..809
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
SQ SEQUENCE 880 AA; 98205 MW; 81A20BF30DAC21E6 CRC64;
MKQVKFLFFS FFIICLALKG VWAMEIAPGL YKTVLDNGLT LIVEENHRAP VVSVQVWVKA
GSAYEKDDEA GITHLIEHMI FKGTEKRKPG EIADTIESFG GNINAFTSYD YTCYYVNGPS
EILDTALDVL SDAIFHSVFD PTELEREKQV VLEEMRMRQD RPALALAEAV MQKAYLKYPY
RRPIIGYPET VKAITRDDIL KYMARRYRPA HMAVVIVGDV EAETALAKAA TYFGQEPKKP
PVEVNFPKEP PKKKPILVTL NKEVQEGYFQ LALPGPSLLD KEAPVMDVIA AILGQGESSR
LYRALRREKG IVHTVYAYTF TPKGPGLFEV AGTAPVENLR ESLKEALVEI FRLKYEPVLP
EELNKAKVMV AADFVYSRET MQGEARKLGA FEMITGDPLK AKAYLEAIKK VTPAQIKEVA
QKFFTPQAVV AGLLAQNVSQ IISQEELENL VEEAEMEASG ITPEMERWVA PTVKKKLPNG
LTVLITPQKD VPSLAMTLVF PGGLRFETKE TNGLFRTLAG LWTKGTTKHS AEVLATLIES
MGGEISGFSG RNTFGLKGVF LADYLDKALS IFAEIAENPA FSQDELEKLK PELLSALARQ
KDDPLQLAVK EFYRLLFSPH PYGLNILGSP EVIQNLTAED IKKAYDSFVA PSRGVLAIVG
DVDPEKVLPL IEKYFGTWQK EAPPLPEDKE PEPLLEPRIS TINMDREQVH LILGFRGPDI
FSQDRYAMEV LNAILAGQGG RLFKELRDKE ALAYSVTSFL TLGINTGGIG FYIATEPAKK
KLALAGLWQE ITKITQEGVT DEEIKRAKRW LVGRYLTSLQ TNSAQAMEQA VNEILGLGYN
YGLRYIQKIQ NVDWENINDV AKKYLQNQSY VLVTVGPIED
//
