ID   F8C2J6_THEGP            Unreviewed;       666 AA.
AC   F8C2J6;
DT   21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT   21-SEP-2011, sequence version 1.
DT   27-MAR-2024, entry version 51.
DE   SubName: Full=Adenylylsulfate reductase, alpha subunit {ECO:0000313|EMBL:AEH22291.1};
GN   OrderedLocusNames=TOPB45_0176 {ECO:0000313|EMBL:AEH22291.1};
OS   Thermodesulfobacterium geofontis (strain OPF15).
OC   Bacteria; Thermodesulfobacteriota; Thermodesulfobacteria;
OC   Thermodesulfobacteriales; Thermodesulfobacteriaceae;
OC   Thermodesulfobacterium.
OX   NCBI_TaxID=795359 {ECO:0000313|EMBL:AEH22291.1, ECO:0000313|Proteomes:UP000006583};
RN   [1] {ECO:0000313|EMBL:AEH22291.1, ECO:0000313|Proteomes:UP000006583}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=OPF15 {ECO:0000313|EMBL:AEH22291.1,
RC   ECO:0000313|Proteomes:UP000006583};
RX   PubMed=23580711; DOI=10.1128/genomea.00162-13;
RA   Elkins J.G., Hamilton-Brehm S.D., Lucas S., Han J., Lapidus A., Cheng J.F.,
RA   Goodwin L.A., Pitluck S., Peters L., Mikhailova N., Davenport K.W.,
RA   Detter J.C., Han C.S., Tapia R., Land M.L., Hauser L., Kyrpides N.C.,
RA   Ivanova N.N., Pagani I., Bruce D., Woyke T., Cottingham R.W.;
RT   "Complete genome sequence of the hyperthermophilic sulfate-reducing
RT   bacterium Thermodesulfobacterium geofontis OPF15T.";
RL   Genome Announc. 1:E0016213-E0016213(2013).
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|ARBA:ARBA00001974};
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DR   EMBL; CP002829; AEH22291.1; -; Genomic_DNA.
DR   RefSeq; WP_013908991.1; NC_015682.1.
DR   AlphaFoldDB; F8C2J6; -.
DR   STRING; 795359.TOPB45_0176; -.
DR   KEGG; top:TOPB45_0176; -.
DR   PATRIC; fig|795359.3.peg.177; -.
DR   eggNOG; COG1053; Bacteria.
DR   HOGENOM; CLU_014312_8_3_0; -.
DR   OrthoDB; 9805351at2; -.
DR   Proteomes; UP000006583; Chromosome.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR   Gene3D; 3.90.700.10; Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain; 1.
DR   InterPro; IPR011803; AprA.
DR   InterPro; IPR003953; FAD-binding_2.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR037099; Fum_R/Succ_DH_flav-like_C_sf.
DR   InterPro; IPR015939; Fum_Rdtase/Succ_DH_flav-like_C.
DR   InterPro; IPR030664; SdhA/FrdA/AprA.
DR   InterPro; IPR027477; Succ_DH/fumarate_Rdtase_cat_sf.
DR   NCBIfam; TIGR02061; aprA; 1.
DR   PANTHER; PTHR11632:SF82; FUMARATE REDUCTASE FLAVOPROTEIN SUBUNIT; 1.
DR   PANTHER; PTHR11632; SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT; 1.
DR   Pfam; PF00890; FAD_binding_2; 1.
DR   Pfam; PF02910; Succ_DH_flav_C; 1.
DR   PIRSF; PIRSF000171; SDHA_APRA_LASPO; 1.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR   SUPFAM; SSF46977; Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain; 1.
DR   SUPFAM; SSF56425; Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   4: Predicted;
KW   Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006583}.
FT   DOMAIN          24..274
FT                   /note="FAD-dependent oxidoreductase 2 FAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF00890"
FT   DOMAIN          543..655
FT                   /note="Fumarate reductase/succinate dehydrogenase
FT                   flavoprotein-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02910"
SQ   SEQUENCE   666 AA;  75130 MW;  DAC4B32C91AF0AB7 CRC64;
     MPKIWHYNPG LECAEPEIVE KETDILIVGG GMAACGAAVE AVQWAKPHGL RIILCDKAAM
     ERSGAVAMGL SAINTYIGEN TPDDYVRMVR CDLMGIVRED LVFDVGRHVD DTVHCFEEWG
     LPIWKKDPQT GKTLDGAEAK AKGLTLKAGA QPVRSGRWQI MINGESYKVI VAEAAKNALT
     GYDKAEIIER CFIVRPLLDA NEPNRCAGAV GFSVRENKIY IIKANATLLA TGGAVNVFRP
     RSIGEGKGRA WYPVWNPGTG YAMCAQIGAK LVLMENRFIP ARFKDGYGPV GAWFLLFKAR
     ATNAFGEDYV AKHKDELKKF APYGEASHIG TCLRNHAMLI EMEAGRGPIY MHTEWALQEA
     AEKMDKKEFK HLVAEAWEDF LDMCVTQAGL WACLNIEPEK LPSEIMPTEP YLLGSHAGCA
     GAWVCGPDED WVPEEYKAPW REIGLYNRMT TVKGLFCAGD TVGASGHKFS SGSHVEGRIA
     AKAMVKFCLD HKDYKPTPKE NPEELKKEIY GPWYRFEQFK TATTAYEVNP NYLIPRHIQD
     RLMKLMDEYV AGCSTFYKTN KVMLERGLEL IKMLKEDMEL AAARDLHELM RAYENRHRVW
     TAEAHLLHIL FREETRYPGY YYRTDFPNLD DANWRCFTLS SYNPETKEWT LETYPYVQII
     PDPLGP
//