ID F8DD77_HALXS Unreviewed; 391 AA.
AC F8DD77;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=glucarate dehydratase {ECO:0000256|ARBA:ARBA00011973};
DE EC=4.2.1.40 {ECO:0000256|ARBA:ARBA00011973};
GN OrderedLocusNames=Halxa_0363 {ECO:0000313|EMBL:AEH38966.1};
OS Halopiger xanaduensis (strain DSM 18323 / JCM 14033 / SH-6).
OG Plasmid pHALXA01 {ECO:0000313|EMBL:AEH38966.1,
OG ECO:0000313|Proteomes:UP000006794}.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Natrialbales;
OC Natrialbaceae; Halopiger.
OX NCBI_TaxID=797210 {ECO:0000313|EMBL:AEH38966.1, ECO:0000313|Proteomes:UP000006794};
RN [1] {ECO:0000313|Proteomes:UP000006794}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 18323 / JCM 14033 / SH-6
RC {ECO:0000313|Proteomes:UP000006794};
RC PLASMID=Plasmid pHALXA01 {ECO:0000313|Proteomes:UP000006794};
RX PubMed=22675596; DOI=10.4056/sigs.2505605;
RA Anderson I., Tindall B.J., Rohde M., Lucas S., Han J., Lapidus A.,
RA Cheng J.F., Goodwin L., Pitluck S., Peters L., Pati A., Mikhailova N.,
RA Pagani I., Teshima H., Han C., Tapia R., Land M., Woyke T., Klenk H.P.,
RA Kyrpides N., Ivanova N.;
RT "Complete genome sequence of Halopiger xanaduensis type strain (SH-6(T)).";
RL Stand. Genomic Sci. 6:31-42(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-glucarate = 5-dehydro-4-deoxy-D-glucarate + H2O;
CC Xref=Rhea:RHEA:14573, ChEBI:CHEBI:15377, ChEBI:CHEBI:30612,
CC ChEBI:CHEBI:42819; EC=4.2.1.40;
CC Evidence={ECO:0000256|ARBA:ARBA00001426};
CC -!- PATHWAY: Carbohydrate acid metabolism; D-glucarate degradation; 2,5-
CC dioxopentanoate from D-glucarate: step 1/2.
CC {ECO:0000256|ARBA:ARBA00005183}.
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DR EMBL; CP002840; AEH38966.1; -; Genomic_DNA.
DR RefSeq; WP_013875694.1; NC_015658.1.
DR AlphaFoldDB; F8DD77; -.
DR GeneID; 10795234; -.
DR KEGG; hxa:Halxa_0363; -.
DR HOGENOM; CLU_030273_3_0_2; -.
DR OrthoDB; 42605at2157; -.
DR Proteomes; UP000006794; Plasmid pHALXA01.
DR GO; GO:0016836; F:hydro-lyase activity; IEA:UniProt.
DR CDD; cd03329; MR_like_4; 1.
DR Gene3D; 3.20.20.120; Enolase-like C-terminal domain; 1.
DR Gene3D; 3.30.390.10; Enolase-like, N-terminal domain; 1.
DR InterPro; IPR034593; DgoD-like.
DR InterPro; IPR036849; Enolase-like_C_sf.
DR InterPro; IPR029017; Enolase-like_N.
DR InterPro; IPR029065; Enolase_C-like.
DR InterPro; IPR013342; Mandelate_racemase_C.
DR InterPro; IPR013341; Mandelate_racemase_N_dom.
DR PANTHER; PTHR48080; D-GALACTONATE DEHYDRATASE-RELATED; 1.
DR PANTHER; PTHR48080:SF4; GLUCARATE DEHYDRATASE; 1.
DR Pfam; PF13378; MR_MLE_C; 1.
DR Pfam; PF02746; MR_MLE_N; 1.
DR SFLD; SFLDS00001; Enolase; 1.
DR SFLD; SFLDG00179; mandelate_racemase; 1.
DR SMART; SM00922; MR_MLE; 1.
DR SUPFAM; SSF51604; Enolase C-terminal domain-like; 1.
DR SUPFAM; SSF54826; Enolase N-terminal domain-like; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Plasmid {ECO:0000313|EMBL:AEH38966.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006794}.
FT DOMAIN 149..254
FT /note="Mandelate racemase/muconate lactonizing enzyme C-
FT terminal"
FT /evidence="ECO:0000259|SMART:SM00922"
SQ SEQUENCE 391 AA; 43790 MW; A8B20E60400912ED CRC64;
MAPTITRIES REFEYPLEDI GTDEHGFNLV YEPGETTWRK LFGIKVHTDE GIAGEYVGGN
SPGAAQINMF ADYLVGKNPL EREKHWSEIK RALRKYDRMG IGPVDIALWD FAGKYYDAPI
HELLGTYRES IPAYASTYHG DENGGLDSPE AFADFAEECL ERGFPGYKIH GWGGSDASRD
LDREIASIEA VGERVGDEMD LMFDPACEYE TFADALKVGR ALDEHGFLWY EDPYRDGGIS
QHGHRKLREQ LETPILQTEH VRGLESHADF VANGGTDFVR ADPEYDAGIT GAMKVVHMAE
SFGLDVEFHA PGPAQRHCIA ATRNTNYYEM ALVHPECQNT QPPVYEGGYS DMMDTVDENG
HVTVPDGPGL GVDYDWDYIE ENQTGQLHVY E
//
