ID F8DXE0_CORRG Unreviewed; 552 AA.
AC F8DXE0;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN OrderedLocusNames=CRES_0322 {ECO:0000313|EMBL:AEI08685.1};
OS Corynebacterium resistens (strain DSM 45100 / JCM 12819 / GTC 2026 / SICGH
OS 158).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales;
OC Corynebacteriaceae; Corynebacterium.
OX NCBI_TaxID=662755 {ECO:0000313|EMBL:AEI08685.1, ECO:0000313|Proteomes:UP000000492};
RN [1] {ECO:0000313|EMBL:AEI08685.1, ECO:0000313|Proteomes:UP000000492}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 45100 / JCM 12819 / GTC 2026 / SICGH 158
RC {ECO:0000313|Proteomes:UP000000492};
RX PubMed=22524407; DOI=10.1186/1471-2164-13-141;
RA Schroder J., Maus I., Meyer K., Wordemann S., Blom J., Jaenicke S.,
RA Schneider J., Trost E., Tauch A.;
RT "Complete genome sequence, lifestyle, and multi-drug resistance of the
RT human pathogen Corynebacterium resistens DSM 45100 isolated from blood
RT samples of a leukemia patient.";
RL BMC Genomics 13:141-141(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the helicase family. RAD25/XPB subfamily.
CC {ECO:0000256|ARBA:ARBA00006637}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP002857; AEI08685.1; -; Genomic_DNA.
DR AlphaFoldDB; F8DXE0; -.
DR STRING; 662755.CRES_0322; -.
DR KEGG; crd:CRES_0322; -.
DR eggNOG; COG1061; Bacteria.
DR HOGENOM; CLU_008213_4_0_11; -.
DR Proteomes; UP000000492; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR CDD; cd18789; SF2_C_XPB; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR032438; ERCC3_RAD25_C.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032830; XPB/Ssl2_N.
DR PANTHER; PTHR11274:SF0; GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB; 1.
DR PANTHER; PTHR11274; RAD25/XP-B DNA REPAIR HELICASE; 1.
DR Pfam; PF16203; ERCC3_RAD25_C; 1.
DR Pfam; PF13625; Helicase_C_3; 1.
DR Pfam; PF04851; ResIII; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000313|EMBL:AEI08685.1};
KW Helicase {ECO:0000313|EMBL:AEI08685.1};
KW Hydrolase {ECO:0000313|EMBL:AEI08685.1};
KW Nucleotide-binding {ECO:0000313|EMBL:AEI08685.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000492}.
FT DOMAIN 197..351
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 405..552
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 552 AA; 61632 MW; 58FA3FCF2EACEC9E CRC64;
MIGLPFGDGP LIVQSDKTVL LEIDHPAAGD ARNALAPFAE LERAPEHVHT YRITPLALWN
ARAAGHDAEQ VVDVLERYSR FPVPQPLLID IADTMDRYGR LTLAKHPAHG LILESKDPAV
LAEIQRHKKI KPMLGPNIDA DTVAVHPSER GRLKQELLKV GWPAEDVAGY VDGEAHRIEL
SQEHEQWQLR DYQEMAADSF WEGGSGVVVL PCGAGKTMVG AAAMAKAKAT TLILVTNTVA
GRQWRDELIR RTSLTEEEIG EYSGEKKEIR PVTIATYQVI TRKTKGEFKA LEVFDSRDWG
LIIYDEVHLL PAPVFRMTSD LQSRRRLGLT ATLVREDGRE GDVFSLIGPK RYDAPWKDIE
AQGWIAPADC TEVRVQLDDD ERMAYAVAEQ SDKYRLAATS PKKNTVVRRI LELHPDEPTL
IIGAYLDQLE EIAEKFDVPV IDGRTGTAKR EKLYQQFRDG EIKVLAVSKV ANFSVDLPSA
SVAIQISGTF GSRQEEAQRL GRILRPKPNG GGAFFYSVVT RDTLDADYAA HRQRFLAEQG
YGYRIMDSED LH
//
