ID F8J721_HYPSM Unreviewed; 602 AA.
AC F8J721;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Chloride channel protein {ECO:0000313|EMBL:CCB65938.1};
GN Name=clc {ECO:0000313|EMBL:CCB65938.1};
GN OrderedLocusNames=HYPMC_2721 {ECO:0000313|EMBL:CCB65938.1};
OS Hyphomicrobium sp. (strain MC1).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Hyphomicrobiaceae; Hyphomicrobium.
OX NCBI_TaxID=717785 {ECO:0000313|EMBL:CCB65938.1, ECO:0000313|Proteomes:UP000000494};
RN [1] {ECO:0000313|Proteomes:UP000000494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MC1 {ECO:0000313|Proteomes:UP000000494};
RA Genoscope.;
RT "The complete genome of Hyphomicrobium sp. MC1.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FQ859181; CCB65938.1; -; Genomic_DNA.
DR RefSeq; WP_013948337.1; NC_015717.1.
DR AlphaFoldDB; F8J721; -.
DR KEGG; hmc:HYPMC_2721; -.
DR eggNOG; COG0038; Bacteria.
DR HOGENOM; CLU_015263_5_2_5; -.
DR Proteomes; UP000000494; Chromosome.
DR GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro.
DR CDD; cd00400; Voltage_gated_ClC; 1.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR PANTHER; PTHR43427; CHLORIDE CHANNEL PROTEIN CLC-E; 1.
DR PANTHER; PTHR43427:SF6; CHLORIDE CHANNEL PROTEIN CLC-E; 1.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF81340; Clc chloride channel; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000494};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 36..59
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 85..103
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 179..203
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 250..270
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 291..309
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 324..345
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 357..378
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 384..409
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 421..441
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 602 AA; 63890 MW; 5F0500D27A9ACF73 CRC64;
MRLFPFGQKR RPLRWAVAVI RVYRGSLRKL LRDNSFILVV AAACVGAASG AIASLMILIS
ETAHQYLFGL NAGERLSSAL DLSPTQVIFI VTLGGVLVGA TYLHQSRLRH VIVDPIEANA
LYGGRMSFRD SAFVALQSLL SSGFGLSLGI EGGFTQAAGA VGSKVGQFLN RRRHDVRMLV
GAGCAGGIAG AFAAPFAGAA YGFELIVGSY TVATLSPVVA AAVAGHLASR LLVGHSYHIP
LNPNGFGSDG YAILALFLGV ACGLLSVGLM RCVTGVERIF RQSKMRDVFR PWAGGLLVGL
MAIFVPHLLG SGHDAMALIL NNEWPVKLLA VVLAGKIVAS ALSLGSGFRG GLFSTSLFLG
AVTGAIAGNL GVMGGVVAPN DVAIISLVGM ASFGAAVVGA PMAMALLAIE VTGDLTVVEP
VLLGVLAATL TVRQVFGYSF ATWRFHLRGE AILGGEDVGW ARQTTARDLM RRDLNTVPIT
MSLADFCARF PVGSTKYVAV ADQKAAYVGL LDVAALHVDQ LNDDAGSTLE DLKSSLEHSN
DWVMASTRFD MLVHLFEQRE TERLIIVDNE TSRHALGYIT EAFALRRYRQ ELEARQREIF
GN
//
