ID F8JHK0_HYPSM Unreviewed; 559 AA.
AC F8JHK0;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=DNA polymerase LigD, polymerase domain protein {ECO:0000313|EMBL:CCB65650.1};
GN OrderedLocusNames=HYPMC_2433 {ECO:0000313|EMBL:CCB65650.1};
OS Hyphomicrobium sp. (strain MC1).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Hyphomicrobiaceae; Hyphomicrobium.
OX NCBI_TaxID=717785 {ECO:0000313|EMBL:CCB65650.1, ECO:0000313|Proteomes:UP000000494};
RN [1] {ECO:0000313|Proteomes:UP000000494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MC1 {ECO:0000313|Proteomes:UP000000494};
RA Genoscope.;
RT "The complete genome of Hyphomicrobium sp. MC1.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; FQ859181; CCB65650.1; -; Genomic_DNA.
DR RefSeq; WP_013948050.1; NC_015717.1.
DR AlphaFoldDB; F8JHK0; -.
DR STRING; 717785.HYPMC_2433; -.
DR KEGG; hmc:HYPMC_2433; -.
DR eggNOG; COG3285; Bacteria.
DR HOGENOM; CLU_008325_0_2_5; -.
DR Proteomes; UP000000494; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd04862; PaeLigD_Pol_like; 1.
DR Gene3D; 3.90.920.10; DNA primase, PRIM domain; 1.
DR InterPro; IPR014144; LigD_PE_domain.
DR InterPro; IPR014145; LigD_pol_dom.
DR InterPro; IPR033651; PaeLigD_Pol-like.
DR NCBIfam; TIGR02777; LigD_PE_dom; 1.
DR NCBIfam; TIGR02778; ligD_pol; 1.
DR PANTHER; PTHR42705; BIFUNCTIONAL NON-HOMOLOGOUS END JOINING PROTEIN LIGD; 1.
DR PANTHER; PTHR42705:SF2; MULTIFUNCTIONAL NON-HOMOLOGOUS END JOINING DNA REPAIR PROTEIN LIGD; 1.
DR Pfam; PF13298; LigD_N; 1.
DR Pfam; PF21686; LigD_Prim-Pol; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000000494}.
FT DOMAIN 38..145
FT /note="DNA ligase D 3'-phosphoesterase"
FT /evidence="ECO:0000259|Pfam:PF13298"
FT DOMAIN 287..536
FT /note="DNA ligase D polymerase"
FT /evidence="ECO:0000259|Pfam:PF21686"
FT REGION 173..261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 203..235
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 559 AA; 61835 MW; 6CA92E9321E7AE23 CRC64;
MAKRKLSEYR AKRDFTKTAE PSGTSVVRPA QHLRFVIQKH DATRLHYDFR LELDGVFKSW
AVTRGPSVDP KDKRLAVEVE DHPLDYGDFE GTIPKGQYGG GTVMLWDRGF WAPVGDKSPE
QQLRDGELKF VLAGEKLKGS WVLVKMKNDR YGGGKRNNWL LIKHKDEGAR AGDADKILSQ
DRSVASKRTM TQIAAGEGHG PEPFILRGRR AKRPDAVWHS NASPDDDEPK PAARKKPLKR
TPVRKMRKTG TKSQSDAPST ADKVLGIAIS HPEKELWPGG TGEAVSKLDL AHYLETVGEW
MLPHIKGRPC SVIRAPDGID GQSFFQRHAM RGMSPEIDLV KISGDREPYI EVNSVEGLIA
LGQIAALEFH PWNCAPFEPD VPGRLVFDLD PAPDVDFGRV VVAANELRER LEDVGLVAFC
KTTGGKGIHV VTPLKTRGGA GVGWDEAKAF AGALCQQMAK DSPDAYLIKM TKKLRKGRIF
LDYLRNDRMA TAVAPLSPRA RPGATVSMPL TWAQVKQGLD PKRFTVHSVP ALLKKSSAWK
DYCDSERPLK TAIKKLLGS
//
