ID F8JT73_STREN Unreviewed; 319 AA.
AC F8JT73; G8WRT8;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Hydroxymethylglutaryl-CoA lyase {ECO:0000313|EMBL:AEW94222.1};
GN OrderedLocusNames=SCATT_18510 {ECO:0000313|EMBL:AEW94222.1};
OS Streptantibioticus cattleyicolor (strain ATCC 35852 / DSM 46488 / JCM 4925
OS / NBRC 14057 / NRRL 8057) (Streptomyces cattleya).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptantibioticus.
OX NCBI_TaxID=1003195 {ECO:0000313|EMBL:AEW94222.1, ECO:0000313|Proteomes:UP000007842};
RN [1] {ECO:0000313|Proteomes:UP000007842}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35852 / DSM 46488 / JCM 4925 / NBRC 14057 / NRRL 8057
RC {ECO:0000313|Proteomes:UP000007842};
RA Ou H.-Y., Li P., Zhao C., O'Hagan D., Deng Z.;
RT "Complete genome sequence of Streptomyces cattleya strain DSM 46488.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the HMG-CoA lyase family.
CC {ECO:0000256|ARBA:ARBA00009405}.
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DR EMBL; CP003219; AEW94222.1; -; Genomic_DNA.
DR RefSeq; WP_014142614.1; NC_017586.1.
DR AlphaFoldDB; F8JT73; -.
DR STRING; 1003195.SCATT_18510; -.
DR KEGG; scy:SCATT_18510; -.
DR PATRIC; fig|1003195.11.peg.3394; -.
DR eggNOG; COG0119; Bacteria.
DR HOGENOM; CLU_022138_3_2_11; -.
DR OrthoDB; 9784013at2; -.
DR Proteomes; UP000007842; Chromosome.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016833; F:oxo-acid-lyase activity; IEA:InterPro.
DR CDD; cd07938; DRE_TIM_HMGL; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR043594; HMGL.
DR InterPro; IPR000891; PYR_CT.
DR PANTHER; PTHR42738; HYDROXYMETHYLGLUTARYL-COA LYASE; 1.
DR PANTHER; PTHR42738:SF7; HYDROXYMETHYLGLUTARYL-COA LYASE; 1.
DR Pfam; PF00682; HMGL-like; 1.
DR SUPFAM; SSF51569; Aldolase; 1.
DR PROSITE; PS50991; PYR_CT; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000313|EMBL:AEW94222.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000007842}.
FT DOMAIN 24..291
FT /note="Pyruvate carboxyltransferase"
FT /evidence="ECO:0000259|PROSITE:PS50991"
SQ SEQUENCE 319 AA; 33452 MW; 5A83D71C5260E4DB CRC64;
MTGVALPAPG LPMAVPQEGL PARVRIHEVG ARDGLQNEKS TVPTEVKAEF IRRLAEAGLT
TIEATSFVHP KWVPQLADAE RLMPLVSGLG VRLPVLVPNE RGLERALALG VREVAVFGSV
TESFAKANLN RTVDESLAMF EPVVAKARQA GARVRGYLSM CFGDPWEGAV PVPQVVAVAR
RLADLGCQEL SLGDTIGVAT PGHVAALLTA LGEAGLGPER LAVHFHDTYG QALANTLAAL
RHGVATVDAS AGGLGGCPYA RSATGNLATE DLVWMLNGLG IDTGVDLTRL TATSVWMAEQ
LGRPSPSRTV RALSHEESS
//
