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Database: UniProt
Entry: F8JVR4_STREN
LinkDB: F8JVR4_STREN
Original site: F8JVR4_STREN 
ID   F8JVR4_STREN            Unreviewed;       815 AA.
AC   F8JVR4; G8X3C3;
DT   21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT   21-SEP-2011, sequence version 1.
DT   24-JAN-2024, entry version 74.
DE   RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE            EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
GN   OrderedLocusNames=SCATT_46040 {ECO:0000313|EMBL:AEW96975.1};
OS   Streptantibioticus cattleyicolor (strain ATCC 35852 / DSM 46488 / JCM 4925
OS   / NBRC 14057 / NRRL 8057) (Streptomyces cattleya).
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptantibioticus.
OX   NCBI_TaxID=1003195 {ECO:0000313|EMBL:AEW96975.1, ECO:0000313|Proteomes:UP000007842};
RN   [1] {ECO:0000313|Proteomes:UP000007842}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35852 / DSM 46488 / JCM 4925 / NBRC 14057 / NRRL 8057
RC   {ECO:0000313|Proteomes:UP000007842};
RA   Ou H.-Y., Li P., Zhao C., O'Hagan D., Deng Z.;
RT   "Complete genome sequence of Streptomyces cattleya strain DSM 46488.";
RL   Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP-dependent breakage, passage and rejoining of double-
CC         stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC   -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC       family. {ECO:0000256|ARBA:ARBA00008263}.
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DR   EMBL; CP003219; AEW96975.1; -; Genomic_DNA.
DR   RefSeq; WP_014145317.1; NC_017586.1.
DR   AlphaFoldDB; F8JVR4; -.
DR   STRING; 1003195.SCATT_46040; -.
DR   KEGG; scy:SCATT_46040; -.
DR   PATRIC; fig|1003195.11.peg.6047; -.
DR   eggNOG; COG0188; Bacteria.
DR   HOGENOM; CLU_002977_6_1_11; -.
DR   OMA; ATGGVRC; -.
DR   OrthoDB; 9806486at2; -.
DR   Proteomes; UP000007842; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0034335; F:DNA negative supercoiling activity; IEA:UniProt.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   CDD; cd00187; TOP4c; 1.
DR   Gene3D; 3.30.1360.40; -; 1.
DR   Gene3D; 2.120.10.90; DNA gyrase/topoisomerase IV, subunit A, C-terminal; 1.
DR   Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR   Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR   InterPro; IPR006691; GyrA/parC_rep.
DR   InterPro; IPR035516; Gyrase/topoIV_suA_C.
DR   InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a_sf.
DR   InterPro; IPR002205; Topo_IIA_dom_A.
DR   PANTHER; PTHR43493:SF5; DNA GYRASE SUBUNIT A, CHLOROPLASTIC/MITOCHONDRIAL; 1.
DR   PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR   Pfam; PF03989; DNA_gyraseA_C; 2.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF101904; GyrA/ParC C-terminal domain-like; 1.
DR   SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:AEW96975.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007842};
KW   Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT   DOMAIN          21..476
FT                   /note="DNA topoisomerase type IIA"
FT                   /evidence="ECO:0000259|SMART:SM00434"
FT   REGION          781..815
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   815 AA;  88079 MW;  F175457946074D20 CRC64;
     MARRSTKTPP EDDFEERILD IDVVDEMQRS YLEYAYSVIY SRALPDARDG LKPVQRRIIY
     QMNEMGLRPD RGYVKCARVV GEVMGKLHPH GDASIYDALV RMAQDFSQRV PLVDGHGNFG
     SLGNDDPPAA MRYTEARMAP TANLMTDSID EDTVDFAPNY DGQEQEPVTL PAAFPNLLVN
     GASGIAVGMA TNMPPHNLTE VVAAARHLIK HPGADLDTLM RFIPGPDLPT GGRIVGLSGI
     RDAYETGRGT FKIRATATIE TVTARRKGIV VTELPFNVGP EKVVAKIKDL VGAKKLQGIA
     DVKDLTDREH GLRLVIEVKN GFNPEAVLEQ LYKLTPMEES FGINNVALVD GQPLTLGLKE
     LLEVYVDHRF DVVRRRSEFR RGKRSDRLHL VEGLLVALVD IDEVIRLIRS SENSAQAKER
     LMAHFSLSEA QTQYILDTPL RRLTKFDRLE LESERDRLTA EIAELTKVLE SDAELRKLVS
     GELAAVAKKY GTDRRTVLLE SAGAPVAAVP LEISDDPCRV LLSSTGLLAR TERDEEFQPA
     GGKRGKHDVI VSAVPATTRG DVGVVTSAGR LLRVSVVDLP VLPEKAAPTL SGGAPVTEFV
     SLAEGERVLC LSTLDESSPG LALGTEQGVV KRVVPDFPGN KDEFEVITLK EGDRLVGATE
     LRTGEEDLVF VTDDAQLLRY PAGQVRPQGR PAGGMAGIKL GAGAKVISFT AVDPGSDAVV
     LTVARAEGTL DGTTQSSAKL TPFDQYPRKG RATGGVRCQR FLRGEDGLAF AWAGPAPARA
     CAADGSPADL PDPDPRRDGS GVALRKPITA VAGPA
//
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