ID F8JVR4_STREN Unreviewed; 815 AA.
AC F8JVR4; G8X3C3;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 24-JAN-2024, entry version 74.
DE RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
GN OrderedLocusNames=SCATT_46040 {ECO:0000313|EMBL:AEW96975.1};
OS Streptantibioticus cattleyicolor (strain ATCC 35852 / DSM 46488 / JCM 4925
OS / NBRC 14057 / NRRL 8057) (Streptomyces cattleya).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptantibioticus.
OX NCBI_TaxID=1003195 {ECO:0000313|EMBL:AEW96975.1, ECO:0000313|Proteomes:UP000007842};
RN [1] {ECO:0000313|Proteomes:UP000007842}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35852 / DSM 46488 / JCM 4925 / NBRC 14057 / NRRL 8057
RC {ECO:0000313|Proteomes:UP000007842};
RA Ou H.-Y., Li P., Zhao C., O'Hagan D., Deng Z.;
RT "Complete genome sequence of Streptomyces cattleya strain DSM 46488.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-dependent breakage, passage and rejoining of double-
CC stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC family. {ECO:0000256|ARBA:ARBA00008263}.
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DR EMBL; CP003219; AEW96975.1; -; Genomic_DNA.
DR RefSeq; WP_014145317.1; NC_017586.1.
DR AlphaFoldDB; F8JVR4; -.
DR STRING; 1003195.SCATT_46040; -.
DR KEGG; scy:SCATT_46040; -.
DR PATRIC; fig|1003195.11.peg.6047; -.
DR eggNOG; COG0188; Bacteria.
DR HOGENOM; CLU_002977_6_1_11; -.
DR OMA; ATGGVRC; -.
DR OrthoDB; 9806486at2; -.
DR Proteomes; UP000007842; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0034335; F:DNA negative supercoiling activity; IEA:UniProt.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00187; TOP4c; 1.
DR Gene3D; 3.30.1360.40; -; 1.
DR Gene3D; 2.120.10.90; DNA gyrase/topoisomerase IV, subunit A, C-terminal; 1.
DR Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR InterPro; IPR006691; GyrA/parC_rep.
DR InterPro; IPR035516; Gyrase/topoIV_suA_C.
DR InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR InterPro; IPR013758; Topo_IIA_A/C_ab.
DR InterPro; IPR013757; Topo_IIA_A_a_sf.
DR InterPro; IPR002205; Topo_IIA_dom_A.
DR PANTHER; PTHR43493:SF5; DNA GYRASE SUBUNIT A, CHLOROPLASTIC/MITOCHONDRIAL; 1.
DR PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR Pfam; PF03989; DNA_gyraseA_C; 2.
DR Pfam; PF00521; DNA_topoisoIV; 1.
DR SMART; SM00434; TOP4c; 1.
DR SUPFAM; SSF101904; GyrA/ParC C-terminal domain-like; 1.
DR SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:AEW96975.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000007842};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 21..476
FT /note="DNA topoisomerase type IIA"
FT /evidence="ECO:0000259|SMART:SM00434"
FT REGION 781..815
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 815 AA; 88079 MW; F175457946074D20 CRC64;
MARRSTKTPP EDDFEERILD IDVVDEMQRS YLEYAYSVIY SRALPDARDG LKPVQRRIIY
QMNEMGLRPD RGYVKCARVV GEVMGKLHPH GDASIYDALV RMAQDFSQRV PLVDGHGNFG
SLGNDDPPAA MRYTEARMAP TANLMTDSID EDTVDFAPNY DGQEQEPVTL PAAFPNLLVN
GASGIAVGMA TNMPPHNLTE VVAAARHLIK HPGADLDTLM RFIPGPDLPT GGRIVGLSGI
RDAYETGRGT FKIRATATIE TVTARRKGIV VTELPFNVGP EKVVAKIKDL VGAKKLQGIA
DVKDLTDREH GLRLVIEVKN GFNPEAVLEQ LYKLTPMEES FGINNVALVD GQPLTLGLKE
LLEVYVDHRF DVVRRRSEFR RGKRSDRLHL VEGLLVALVD IDEVIRLIRS SENSAQAKER
LMAHFSLSEA QTQYILDTPL RRLTKFDRLE LESERDRLTA EIAELTKVLE SDAELRKLVS
GELAAVAKKY GTDRRTVLLE SAGAPVAAVP LEISDDPCRV LLSSTGLLAR TERDEEFQPA
GGKRGKHDVI VSAVPATTRG DVGVVTSAGR LLRVSVVDLP VLPEKAAPTL SGGAPVTEFV
SLAEGERVLC LSTLDESSPG LALGTEQGVV KRVVPDFPGN KDEFEVITLK EGDRLVGATE
LRTGEEDLVF VTDDAQLLRY PAGQVRPQGR PAGGMAGIKL GAGAKVISFT AVDPGSDAVV
LTVARAEGTL DGTTQSSAKL TPFDQYPRKG RATGGVRCQR FLRGEDGLAF AWAGPAPARA
CAADGSPADL PDPDPRRDGS GVALRKPITA VAGPA
//