ID   F8K4P5_STREN            Unreviewed;      1083 AA.
AC   F8K4P5; G8WUV8;
DT   21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT   21-SEP-2011, sequence version 1.
DT   27-MAR-2024, entry version 76.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN   OrderedLocusNames=SCATT_40300 {ECO:0000313|EMBL:AEW96401.1};
OS   Streptantibioticus cattleyicolor (strain ATCC 35852 / DSM 46488 / JCM 4925
OS   / NBRC 14057 / NRRL 8057) (Streptomyces cattleya).
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptantibioticus.
OX   NCBI_TaxID=1003195 {ECO:0000313|EMBL:AEW96401.1, ECO:0000313|Proteomes:UP000007842};
RN   [1] {ECO:0000313|Proteomes:UP000007842}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35852 / DSM 46488 / JCM 4925 / NBRC 14057 / NRRL 8057
RC   {ECO:0000313|Proteomes:UP000007842};
RA   Ou H.-Y., Li P., Zhao C., O'Hagan D., Deng Z.;
RT   "Complete genome sequence of Streptomyces cattleya strain DSM 46488.";
RL   Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
CC   -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC       {ECO:0000256|ARBA:ARBA00009922}.
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DR   EMBL; CP003219; AEW96401.1; -; Genomic_DNA.
DR   AlphaFoldDB; F8K4P5; -.
DR   STRING; 1003195.SCATT_40300; -.
DR   KEGG; scy:SCATT_40300; -.
DR   PATRIC; fig|1003195.11.peg.5490; -.
DR   eggNOG; COG0210; Bacteria.
DR   eggNOG; COG2887; Bacteria.
DR   HOGENOM; CLU_004900_0_0_11; -.
DR   OrthoDB; 5240387at2; -.
DR   Proteomes; UP000007842; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR   CDD; cd17932; DEXQc_UvrD; 1.
DR   Gene3D; 1.10.10.160; -; 1.
DR   Gene3D; 3.90.320.10; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR011604; PDDEXK-like_dom_sf.
DR   InterPro; IPR038726; PDDEXK_AddAB-type.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070:SF59; DNA HELICASE; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF12705; PDDEXK_1; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR   PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000007842}.
FT   DOMAIN          18..321
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51198"
FT   DOMAIN          321..645
FT                   /note="UvrD-like helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51217"
FT   BINDING         39..46
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ   SEQUENCE   1083 AA;  116611 MW;  B8E290ABF4FC7EDF CRC64;
     MPGGYRLVRT PPEQVEPPVL DARQRAVVEH DGGPLLVLAG PGTGKTTTLV EAVAARVARG
     GDPERVLVLT FSRKAATELR DRMAARMPVA PRATTFHSFC YALVRAEQAP DLFAEPLRLF
     SGPEQDLAVR ELLAGHAELA RAGHAPVRWP DDVRAGLTTR GFADEVRAVL ARTRELGLGP
     GDLAAFAARA GRPDWSAAAR FLNEYLDVLD AQGAVDYAEL VHRAVLLAER PGAAARITAR
     YDAVYLDEYQ DTDAAQVRLV RALAGDHRAG RTLVAFGDPD QSIYAFRGAD VGGIIDFPET
     FRRPDGRPAP VVVLGVSRRA GARLLAATRL ITARMPLPRL PADAVRAHRE PAADRPGGRV
     EVYTYPTPGA ETANIADILR RAHLEDGVPW REMAVLVRAG ARGLPVLRRA LTQAGVPVDI
     DGDDLPLRAE PAVAPLLLAL RVVATPAPPP EDPDEDAGPS FPLPVADAIA LLTSPLGGMD
     AADLRRLGRA LREEERAAGQ AVPRPSDVLL AEALAQPERL VAHDQSYARG ARRLGERLAR
     ARAILAGGGT AHDALWALWH ETPWADRLAR AAHGGGAAAR NADRDLDAVC ALFDTAARAE
     QRTGGRGALN FLEELDAQDI AADVLTRRAV RPDAVRLMTA HRAKGLEWHL VVVAGVQEGL
     WPDLRRRGSV LEADRIGRDG LAEPLTPGAL LAEERRLFYV AATRARERLV VTAVKAPADD
     GDQPSRFLAE LGVEPRDVTQ RPLRPLAVAA LVAELRATTV DPAASPALRD AAARRLARLA
     ALADDEGRPL VPAAHPDRWW GLYEPTRSAV PLRDRDRPVT LTGSALDQLV NACSLQWFLG
     REVRAEDPAS TAQGFGNVVH VLADEVASGQ TPARLDALLA RLDSVWDSLA FDAPWKSRQE
     RDQARAALER FLRWHVLERG REPVATEHGF DVTLGAGEYQ VRVRGSMDRV ERDAAGHAYV
     VDFKTGRSAP TGPEVAAHPQ LAVYQLAVRE GAVDDLFDGH RPEPGGAELV HLRLPAPKKE
     GGDTLPKVQT QPPPDTDWAA GLLAEAAGRV LDERFTPAPG RPCGTCSFRP ACPARPEGRQ
     IVE
//