ID F8L2V3_SIMNZ Unreviewed; 1051 AA.
AC F8L2V3;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Cation efflux system protein CusA {ECO:0000313|EMBL:CCB87799.1};
GN Name=cusA {ECO:0000313|EMBL:CCB87799.1};
GN OrderedLocusNames=SNE_B24400 {ECO:0000313|EMBL:CCB87799.1};
OS Simkania negevensis (strain ATCC VR-1471 / Z).
OG Plasmid pSn {ECO:0000313|EMBL:CCB87799.1,
OG ECO:0000313|Proteomes:UP000000496}.
OC Bacteria; Chlamydiota; Chlamydiia; Parachlamydiales; Simkaniaceae;
OC Simkania.
OX NCBI_TaxID=331113 {ECO:0000313|EMBL:CCB87799.1, ECO:0000313|Proteomes:UP000000496};
RN [1]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Z;
RA Collingro A., Tischler P., Weinmaier T., Penz T., Heinz E., Brunham R.C.,
RA Read T.D., Bavoil P.M., Sachse K., Kahane S., Friedman M.G., Rattei T.,
RA Myers G.S.A., Horn M.;
RT "Unity in variety -- the pan-genome of the Chlamydiae.";
RL Mol. Biol. Evol. 0:0-0(2011).
RN [2] {ECO:0000313|EMBL:CCB87799.1, ECO:0000313|Proteomes:UP000000496}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC VR-1471 / Z {ECO:0000313|Proteomes:UP000000496};
RC PLASMID=pSn {ECO:0000313|EMBL:CCB87799.1,
RC ECO:0000313|Proteomes:UP000000496};
RX PubMed=21690563; DOI=10.1093/molbev/msr161;
RA Collingro A., Tischler P., Weinmaier T., Penz T., Heinz E., Brunham R.C.,
RA Read T.D., Bavoil P.M., Sachse K., Kahane S., Friedman M.G., Rattei T.,
RA Myers G.S., Horn M.;
RT "Unity in variety--the pan-genome of the Chlamydiae.";
RL Mol. Biol. Evol. 28:3253-3270(2011).
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DR EMBL; FR872581; CCB87799.1; -; Genomic_DNA.
DR RefSeq; WP_013935033.1; NC_015710.1.
DR AlphaFoldDB; F8L2V3; -.
DR KEGG; sng:SNE_B24400; -.
DR eggNOG; COG3696; Bacteria.
DR HOGENOM; CLU_002755_1_2_0; -.
DR OrthoDB; 8270at2; -.
DR Proteomes; UP000000496; Plasmid pSn.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR004763; CusA-like.
DR NCBIfam; TIGR00914; 2A0601; 1.
DR PANTHER; PTHR32063; -; 1.
DR PANTHER; PTHR32063:SF19; CATION EFFLUX SYSTEM PROTEIN CUSA; 1.
DR Pfam; PF00873; ACR_tran; 1.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius}; Plasmid {ECO:0000313|EMBL:CCB87799.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000496};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 14..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 338..357
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 364..384
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 390..410
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 442..461
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 476..497
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 530..547
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 876..896
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 903..923
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 929..953
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 984..1003
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1015..1041
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 1051 AA; 117104 MW; 00CC9722A38CF905 CRC64;
MIAKIIEWSA KNRFIIYVIT VLMLIWAGYA IRNTPMDALP DLSDTQVIIF TEWKGQSPNL
IEDQVTYPIV SAFLSAPNVK VVRGFTMFGF SFVYVLFEEG TDIYWARSRT LEYLSPLQGQ
LPKGVTPTIG PDATGVGWVF EYALIDESGR YNLQQLRSFQ DWYLRYWLAA VPGVAEIASV
GGYEKEYQVE VDPVKLQSYG LSINHVRKAL QDSNLYIGAR VIEMAQHEYA VRGSGYITDS
KMIEQVVVGT DQMGSPVTIK DLSRVQIGGN IRRGLAELDG KGEVVGGIVV MRYGENPLKV
IKDIKTKIKQ VQSAFPPGVK LVTTYDRSRL IIDSMKTLFE NIGEELILVF LIIYIFLFHF
RSSLVSILTL PVAVILAFIP MYYMGLSANI MSLAGIIIAI GDVVDSAVIM TENAHKKLEE
NKEGKPHLDV VLEAAKELGP SIFASLLIIV IGFIPIFSLQ AQEGKLFSPL AYTKTFAVAF
GALLGITLVP ALMMSFIKGK IRPSLSNPVN KVLGYVYRPA LQFCLNHRKT VVCGTLILIV
SAIPFYLKLG SEFMPPLDEK DILFMPITTP GISIEAAREL VQKQDGILYS FPEVKRVFGK
AGRADTSTDP APLSMIETVI LLHPKDKWRK GMTKDKLIQE MNEALNFKGV QNAFTMPIKA
RLDMLTTGIR TAVGVKVFGD NLETINQIGT HLETILKKVP GTRSVYAERE LGGFYIDFIP
DRDALARYGL TITEVMGFVQ SAIGGEDITE TIEGRERYTV NIRYPRGLRD DVSTLKQALV
PINKPMARME DTQELSKFAH VPLGQLGEVK VTMGPSMIKD EMGYFSGWVY VDLETSDIGG
FVDIAKQAVA SELKLPRGYF LKWTGQYEYL ERIQTLLSYM VPLTILLVLL ILYMNFKAFI
PSLIVMLSVP FAAIGAIFFL SFAGYNTSVA VWVGMIALLG IAAQTISIML VYLEEGYKRW
ETDGKIQSAQ DIITMTLSQA TLRIRPFMMA IGLNIIGLIP IMVSDKVGSD IAKRIALPLW
GGLVSLTLLT LFVIPVIFVL WKTYVYKRKK E
//
