ID F8L497_SIMNZ Unreviewed; 707 AA.
AC F8L497;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN Name=pcrA-B {ECO:0000313|EMBL:CCB90145.1};
GN OrderedLocusNames=SNE_A22680 {ECO:0000313|EMBL:CCB90145.1};
OS Simkania negevensis (strain ATCC VR-1471 / Z).
OC Bacteria; Chlamydiota; Chlamydiia; Parachlamydiales; Simkaniaceae;
OC Simkania.
OX NCBI_TaxID=331113 {ECO:0000313|EMBL:CCB90145.1, ECO:0000313|Proteomes:UP000000496};
RN [1] {ECO:0000313|EMBL:CCB90145.1, ECO:0000313|Proteomes:UP000000496}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC VR-1471 / Z {ECO:0000313|Proteomes:UP000000496};
RX PubMed=21690563; DOI=10.1093/molbev/msr161;
RA Collingro A., Tischler P., Weinmaier T., Penz T., Heinz E., Brunham R.C.,
RA Read T.D., Bavoil P.M., Sachse K., Kahane S., Friedman M.G., Rattei T.,
RA Myers G.S., Horn M.;
RT "Unity in variety--the pan-genome of the Chlamydiae.";
RL Mol. Biol. Evol. 28:3253-3270(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
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DR EMBL; FR872582; CCB90145.1; -; Genomic_DNA.
DR RefSeq; WP_013944611.1; NC_015713.1.
DR AlphaFoldDB; F8L497; -.
DR STRING; 331113.SNE_A22680; -.
DR KEGG; sng:SNE_A22680; -.
DR eggNOG; COG0210; Bacteria.
DR HOGENOM; CLU_004585_5_2_0; -.
DR OrthoDB; 9810135at2; -.
DR Proteomes; UP000000496; Chromosome gsn.131.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000000496}.
FT DOMAIN 2..277
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 278..556
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 23..30
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 707 AA; 81207 MW; E13E9F32E9AD4511 CRC64;
MIDLNAKQQL AAEHIEGPML VLAGAGSGKT RVVTCRIAHL LKIGVPSSEI LALTFTNKAA
EEMRNRIKEI ANHYVLTSTF HSLGARILRE SISVLGYRSD FTIYDENDSL QLLKNCLGSL
GYKDDKGLLK SLRIAISNAK NDLLRPQDLD RDFHSRHDQL LKELYVMYQD KLKEYNALDF
DDLLFLTVRL FRESPETLKR YQKRWSFILI DEYQDTNAAQ YEMTKLLSEV HNNIFVVGDP
DQSIYSWRGA NIHNILEFEK DYAGAQVITL EQNYRSTTNI LEGANALIEQ NEQRYKKELW
SDLGAGEKIG IFMARNEQAE AQFVVEELIS KTRSEHIPLR ECVIFYRTNA QSRIFEDAFL
KYQIPYVIIG GLSFYQRREI KDILALLRMV VSNADFLSFA RTINLPKRGI GPTTLNKWRD
LAEELALPIL SLCRELMSGN VTQAPLTKKQ EEGLRDYFGV LASLKSMCDE RLPLEEIVQA
AIEQSRYLDV LKADPETASD RKENLEALIN KAAEWSEERE TPTLIHFLEE LSLKSSLDEA
PEYDSVRLMT LHNGKGLEFD LTFIVGMEED LFPHINSKDS IEALEEERRL CYVGMTRAKQ
FLYLTASTYR FMWGTPKVMV PSRFLKEVPP EYLTVLSAEE KEEEEFHFDD EEKMAIGTVV
FHKDFGKGLI KKAYNTSLGV TYDVLFFESN MVRSLVGKYA KFKNLST
//
