ID F8L6R2_SIMNZ Unreviewed; 643 AA.
AC F8L6R2;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=Chaperone protein DnaK {ECO:0000256|HAMAP-Rule:MF_00332};
DE AltName: Full=HSP70 {ECO:0000256|HAMAP-Rule:MF_00332};
DE AltName: Full=Heat shock 70 kDa protein {ECO:0000256|HAMAP-Rule:MF_00332};
DE AltName: Full=Heat shock protein 70 {ECO:0000256|HAMAP-Rule:MF_00332};
GN Name=dnaK-B {ECO:0000313|EMBL:CCB88410.1};
GN Synonyms=dnaK {ECO:0000256|HAMAP-Rule:MF_00332};
GN OrderedLocusNames=SNE_A05330 {ECO:0000313|EMBL:CCB88410.1};
OS Simkania negevensis (strain ATCC VR-1471 / Z).
OC Bacteria; Chlamydiota; Chlamydiia; Parachlamydiales; Simkaniaceae;
OC Simkania.
OX NCBI_TaxID=331113 {ECO:0000313|EMBL:CCB88410.1, ECO:0000313|Proteomes:UP000000496};
RN [1]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Z;
RA Collingro A., Tischler P., Weinmaier T., Penz T., Heinz E., Brunham R.C.,
RA Read T.D., Bavoil P.M., Sachse K., Kahane S., Friedman M.G., Rattei T.,
RA Myers G.S.A., Horn M.;
RT "Unity in variety -- the pan-genome of the Chlamydiae.";
RL Mol. Biol. Evol. 0:0-0(2011).
RN [2] {ECO:0000313|EMBL:CCB88410.1, ECO:0000313|Proteomes:UP000000496}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC VR-1471 / Z {ECO:0000313|Proteomes:UP000000496};
RX PubMed=21690563; DOI=10.1093/molbev/msr161;
RA Collingro A., Tischler P., Weinmaier T., Penz T., Heinz E., Brunham R.C.,
RA Read T.D., Bavoil P.M., Sachse K., Kahane S., Friedman M.G., Rattei T.,
RA Myers G.S., Horn M.;
RT "Unity in variety--the pan-genome of the Chlamydiae.";
RL Mol. Biol. Evol. 28:3253-3270(2011).
CC -!- FUNCTION: Acts as a chaperone. {ECO:0000256|HAMAP-Rule:MF_00332}.
CC -!- INDUCTION: By stress conditions e.g. heat shock. {ECO:0000256|HAMAP-
CC Rule:MF_00332}.
CC -!- SIMILARITY: Belongs to the heat shock protein 70 family.
CC {ECO:0000256|ARBA:ARBA00007381, ECO:0000256|HAMAP-Rule:MF_00332,
CC ECO:0000256|RuleBase:RU003322}.
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DR EMBL; FR872582; CCB88410.1; -; Genomic_DNA.
DR RefSeq; WP_013942877.1; NC_015713.1.
DR AlphaFoldDB; F8L6R2; -.
DR STRING; 331113.SNE_A05330; -.
DR KEGG; sng:SNE_A05330; -.
DR eggNOG; COG0443; Bacteria.
DR HOGENOM; CLU_005965_2_4_0; -.
DR OrthoDB; 9766019at2; -.
DR Proteomes; UP000000496; Chromosome gsn.131.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR CDD; cd10234; HSPA9-Ssq1-like_NBD; 1.
DR Gene3D; 1.20.1270.10; -; 1.
DR Gene3D; 3.30.420.40; -; 2.
DR HAMAP; MF_00332; DnaK; 1.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR012725; Chaperone_DnaK.
DR InterPro; IPR018181; Heat_shock_70_CS.
DR InterPro; IPR029048; HSP70_C_sf.
DR InterPro; IPR029047; HSP70_peptide-bd_sf.
DR InterPro; IPR013126; Hsp_70_fam.
DR NCBIfam; TIGR02350; prok_dnaK; 1.
DR PANTHER; PTHR19375; HEAT SHOCK PROTEIN 70KDA; 1.
DR PANTHER; PTHR19375:SF184; STRESS-70 PROTEIN, MITOCHONDRIAL; 1.
DR Pfam; PF00012; HSP70; 1.
DR PRINTS; PR00301; HEATSHOCK70.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR SUPFAM; SSF100934; Heat shock protein 70kD (HSP70), C-terminal subdomain; 1.
DR SUPFAM; SSF100920; Heat shock protein 70kD (HSP70), peptide-binding domain; 1.
DR PROSITE; PS00297; HSP70_1; 1.
DR PROSITE; PS00329; HSP70_2; 1.
DR PROSITE; PS01036; HSP70_3; 1.
PE 2: Evidence at transcript level;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00332}; Chaperone {ECO:0000256|HAMAP-Rule:MF_00332};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00332};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553, ECO:0000256|HAMAP-
KW Rule:MF_00332}; Reference proteome {ECO:0000313|Proteomes:UP000000496};
KW Stress response {ECO:0000256|ARBA:ARBA00023016, ECO:0000256|HAMAP-
KW Rule:MF_00332}.
FT REGION 599..643
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 200
FT /note="Phosphothreonine; by autocatalysis"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00332"
SQ SEQUENCE 643 AA; 69789 MW; 77FACCC1B178C851 CRC64;
MTQKKSKVIG IDLGTTNSCV AIMEGGAAKV IANAEGTRTT PSIVSYKDGE RLVGIPAKRQ
AVTNPEKTLY STKRFIGRKY AEVAEEIKTV PYKVVPNSNG DAVFEVDGKT LTPEEVGAQI
LIKMKETAEE YLGEKVTEAV ITVPAYFNDS QRQSTKDAGR IAGLDVKRII PEPTAAALAY
GLDKEGADKK IAVFDLGGGT FDISILEIGD GVFEVLATNG DTHLGGDDFD NVIIQWLLNE
FKKENGIDLS KDKMALQRIK DAAEKAKIEL SGTQQTEINQ PFITMDASGP KHLSLTLTRA
KFESLASDLI ERCVDPCVNA MKDAGITKDQ IHDVLLVGGM SRMPAVQEKV KKIFGKEPHK
GVNPDEVVAT GAAIQGGVLA GDVKDVLLLD VIPLTLGIET LGGIMTPLVE RNTTIPTQKK
QVFSTAVDNQ PAVTIVVLQG ERKMATDNKE IGRFDLTDIP PSPRGSPQIE VSFDIDADGI
LHVSAKDLGT GKEQKIRIEA KSGLSENEIN RMVKDAEEHA DEDKKRKEDV EVKNKGDSLV
FQAEKALKDH KDKIPEKLTK EIQGKIDTLK KALESNDISS IKTATTDLET YIQKIGEEIQ
KQGAAQQQAG PGAGPMGGEA PRREEKKEEE IEEAEVEILD EEK
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