ID F8L7L0_SIMNZ Unreviewed; 1878 AA.
AC F8L7L0;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=UvrABC system protein A {ECO:0000256|ARBA:ARBA00039316};
DE AltName: Full=Excinuclease ABC subunit A {ECO:0000256|ARBA:ARBA00042156};
GN Name=uvrA-A {ECO:0000313|EMBL:CCB88743.1};
GN OrderedLocusNames=SNE_A08660 {ECO:0000313|EMBL:CCB88743.1};
OS Simkania negevensis (strain ATCC VR-1471 / Z).
OC Bacteria; Chlamydiota; Chlamydiia; Parachlamydiales; Simkaniaceae;
OC Simkania.
OX NCBI_TaxID=331113 {ECO:0000313|EMBL:CCB88743.1, ECO:0000313|Proteomes:UP000000496};
RN [1] {ECO:0000313|EMBL:CCB88743.1, ECO:0000313|Proteomes:UP000000496}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC VR-1471 / Z {ECO:0000313|Proteomes:UP000000496};
RX PubMed=21690563; DOI=10.1093/molbev/msr161;
RA Collingro A., Tischler P., Weinmaier T., Penz T., Heinz E., Brunham R.C.,
RA Read T.D., Bavoil P.M., Sachse K., Kahane S., Friedman M.G., Rattei T.,
RA Myers G.S., Horn M.;
RT "Unity in variety--the pan-genome of the Chlamydiae.";
RL Mol. Biol. Evol. 28:3253-3270(2011).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. UvrA family.
CC {ECO:0000256|ARBA:ARBA00038000}.
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DR EMBL; FR872582; CCB88743.1; -; Genomic_DNA.
DR RefSeq; WP_013943210.1; NC_015713.1.
DR STRING; 331113.SNE_A08660; -.
DR KEGG; sng:SNE_A08660; -.
DR eggNOG; COG0178; Bacteria.
DR HOGENOM; CLU_001370_3_0_0; -.
DR OrthoDB; 9809851at2; -.
DR Proteomes; UP000000496; Chromosome gsn.131.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004518; F:nuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-KW.
DR CDD; cd03271; ABC_UvrA_II; 1.
DR Gene3D; 1.10.8.280; ABC transporter ATPase domain-like; 2.
DR Gene3D; 1.20.1580.10; ABC transporter ATPase like domain; 4.
DR Gene3D; 3.30.1490.20; ATP-grasp fold, A domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR013815; ATP_grasp_subdomain_1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004602; UvrA.
DR InterPro; IPR041552; UvrA_DNA-bd.
DR InterPro; IPR041102; UvrA_inter.
DR NCBIfam; TIGR00630; uvra; 2.
DR PANTHER; PTHR43152; UVRABC SYSTEM PROTEIN A; 1.
DR PANTHER; PTHR43152:SF3; UVRABC SYSTEM PROTEIN A; 1.
DR Pfam; PF17755; UvrA_DNA-bind; 1.
DR Pfam; PF17760; UvrA_inter; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 3.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA excision {ECO:0000256|ARBA:ARBA00022769};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Excision nuclease {ECO:0000256|ARBA:ARBA00022881};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000000496};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SOS response {ECO:0000256|ARBA:ARBA00023236};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 608..936
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 942..1532
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 1543..1876
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 1878 AA; 208701 MW; 583984334D5F6421 CRC64;
MTQQPIRLKN VKVHNLKGVD LTLQSGAFIV FTGVSGSGKS SLAFDTIYVE GQRRYIESLS
NYARRYMGNL SKPDADLIEG ISPTIAIEQK TAGRNPRSTV GTMTGIYDYL RVLFARVGTP
HCPISGEKVQ PQSTEQILAT IETFPEKSKL LILAPHTRGK KGEFKDLFDE LIRKGFTRIR
LDQNLVDLSE DIAIDKTTAH DIDLVVDRLA LTKAEKPRLT EAVSQALELG QGVMSVLDHD
TGVETLFSQH AHAKKSGESY SPLEPHDFSF NHPSGMCPTC EGLGVIQDFD LDLIIDPELS
IAEGCCSIAS SYETVKWGNI YDNLADLYNF SLDTPWKKLS ESAKKIFLYG NKKKWTRMRF
VHPKKKTVWT EYVKWHGVLA EAKNRFNEAK SDVYRSNMEK LMHEAVCPDC EGSRIKPYPS
ATKIGSKRIH EVTALTIEEV AHFFDKLKLT PFERMIGRDL LQEIQKRLDF LLNVGLYYLT
LDRTSPTLSG GEAQRVRLAS QIGSGLVAAT YILDEPSIGL HPRDNTKLIA TLKMLRDRGN
TIIVVEHDEE TMDAADYIVD IGPEAGILGG EIVAEGTLDD LIASPRSLTG AYLSGKKKIP
IPKKRIPPSE KKLTIREAKH HNLKNVTIDI PLEVFVAVTG VSGSGKSSLI TDILYPALAN
KLHKAEQRVG KHQTIEGIEH LDKVIAIDQT PIGRTPRSNP STYIKVFDDI RDLFTKLPES
QAFGYKPGRF SFNVAEGSCL ECRGMGMLRI DMDFMDDVWS TCPVCEGKRF DLSTLSILYK
GKSIHEVLEM TVEEASAFFE NIPSIHHKLS LLLKVGLGYI TLGQSSTTLS GGEAQRIKLA
RELTRPATGK TLYILDEPTT GLHFHDIAKL IEILQELRAA GNTVLVIEHN MDMVKTADWI
IDLGPEGGKD GGQITAQGTP EEIAKLKTPT GCAVHSILNP KIRIKSTKKK EVAPPAAALE
VRGAAQNNLK GVSLKIPRNK ITICTGPSGS GKSSLAFDTI YAEGQRRYID SLSSYARQFV
KQMPKPRLEE IDGLSPAIAI EQKHHAGNPR STIGTMTEVY DFLRLLYAHA GIAYCPETGE
KIESITNEYV VNHLMQLPEK TRLHILTPVK ISKSAPFEEL RENLIQKGFL RIRLNGEYYA
LDEEIPYEVG RKNELFLVVD RLAIREGIEK RLFEAIEQVT RLTKEPFIVA TPKEDLLFNL
SFAVPSTGKS YPPITPHTFS FNSDDGMCPD CLGLGFQWGA NMLKHQKVMN MSPFSLMHKL
WKEEWTEEVE KLLLDYLDAE GIDSDTPLYK LPVKQLQLLL NGSTEDFTYN GLIFRWTGIN
AAFTRCAKAG KKQLRESVIP HLEQTTCVTC SGERLSPLAR HVKVQDVTIG KLCSLPLHQV
LKFIQSLQHL TIPLLAETLE QLENRIQFLC NIGLDYLSLD RQAPTLSGGE TQRIHLARQL
GSGLTGCLYV LDEPTIGLHP QNNARLNEAL KHLCKLGNTL LLVEHDPLTL SIADYVFDFG
PQAGKHGGEI VAEGTLAQIK KNPRSLTGQY LSGKKKLPVP EKRRKSKVHI TIRNASKHNL
KNLTLKIPTK ALTCLTGVSG SGKSTLMHAI LKRGVQMHLA ARSQETSIQI DEATIEGVDE
FNKLISIDQN PIGHTIRADV STYNEILTHI RQFYAELPEA KTRGLKPKHF SYNHLKGMCR
TCWGLGFKTI RLQFLPSLKV SCDACKGNRL NPLSSQVTYH GKSLGELLKL TIDEAIHFLP
PIPKLQKSLE TLQNVGLGYL ALGQEIASLS GGEAGRMRLA RELAKRSTGK TLYLFDEPTI
GLHADDIAKL IPLFHALVDK GNTLIIIEHN LDILRIADHI IDLGPEAGEK GGEIIATGTP
EEIEKHPTSY TAAFLRKH
//
