ID   F8N7J5_9BACT            Unreviewed;       977 AA.
AC   F8N7J5;
DT   21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT   21-SEP-2011, sequence version 1.
DT   27-MAR-2024, entry version 65.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN   ORFNames=Premu_2061 {ECO:0000313|EMBL:EGN57455.1};
OS   Hallella multisaccharivorax DSM 17128.
OC   Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Prevotellaceae;
OC   Hallella.
OX   NCBI_TaxID=688246 {ECO:0000313|EMBL:EGN57455.1, ECO:0000313|Proteomes:UP000002772};
RN   [1] {ECO:0000313|Proteomes:UP000002772}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 17128 {ECO:0000313|Proteomes:UP000002772};
RX   PubMed=22180809; DOI=10.4056/sigs.2164949;
RA   Pati A., Gronow S., Lu M., Lapidus A., Nolan M., Lucas S., Hammon N.,
RA   Deshpande S., Cheng J.F., Tapia R., Han C., Goodwin L., Pitluck S.,
RA   Liolios K., Pagani I., Mavromatis K., Mikhailova N., Huntemann M., Chen A.,
RA   Palaniappan K., Land M., Hauser L., Detter J.C., Brambilla E.M., Rohde M.,
RA   Goker M., Woyke T., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA   Kyrpides N.C., Klenk H.P., Ivanova N.;
RT   "Non-contiguous finished genome sequence of the opportunistic oral pathogen
RT   Prevotella multisaccharivorax type strain (PPPA20).";
RL   Stand. Genomic Sci. 5:41-49(2011).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR   EMBL; GL945017; EGN57455.1; -; Genomic_DNA.
DR   RefSeq; WP_007575022.1; NZ_GL945017.1.
DR   AlphaFoldDB; F8N7J5; -.
DR   STRING; 688246.Premu_2061; -.
DR   eggNOG; COG1074; Bacteria.
DR   HOGENOM; CLU_001114_1_2_10; -.
DR   OrthoDB; 9810135at2; -.
DR   Proteomes; UP000002772; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR   CDD; cd17932; DEXQc_UvrD; 1.
DR   Gene3D; 3.90.320.10; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR011604; PDDEXK-like_dom_sf.
DR   InterPro; IPR038726; PDDEXK_AddAB-type.
DR   InterPro; IPR011335; Restrct_endonuc-II-like.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF12705; PDDEXK_1; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR   PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000002772}.
FT   DOMAIN          1..327
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51198"
FT   DOMAIN          328..602
FT                   /note="UvrD-like helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51217"
FT   BINDING         9..16
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ   SEQUENCE   977 AA;  111488 MW;  724DA1D24D416767 CRC64;
     MKNINYISAG AGSGKTYTLT HRLADHIIKG DVKPEEVILT TFTDKAATEF RERAKAALNE
     EYRFDEAGRL DLAEIGTVHS IAYKMVSKYW YILGLSPQLK VMDENDVNFF ISQSLADLPT
     DEEIRFLNDF RQEFDIQRRK DYGFGYISDY DYWKNYLTKI VEKSVIFNVK DFTQSEDFSV
     KQVHDLYDDT KAISMHEQFI KIMFGLASRW KSRYHDYKRE QHTLDFNDME QYFLELLDKK
     EVSSDISSSY KYLFVDEFQD SSPVQVQIFD KLSDLMEKSY FVGDFKQAIY GFRGTDAALT
     EAVSNIISQG KNGCKMEKPL DTCWRSQPNI VRTVNSVFVK AFNALTPEAK ARIELKPCQP
     MLDNENDDCL TYLDCGLNAS DKTGNIIHLA RDIAYIVAHG VKPTELAVLA RSNGELDELA
     SNLSDYKLPV MRDGGSIAES KETTLLFAML RLLSNRGDQL AKAEIAYITE QGYSIGRIID
     KKILFDDNKD EHKGNFLDDI PMVAKLLSRY DELHNMSVTT LVETLVLEFD LKNLSRKWDK
     TSVAYSNFDA IIASAKTYEQ HCQQMTLPST IDGFMQYLTN QPPVQAGDIN GIRLFTYHGA
     KGLEWNHVIV MSLQNDAVLE RTMIQKNFYG VSAFHEVEPS SVNLYPPMTI SLLPWIYGTK
     QTIQNTDIKR KIIASKRYQI TLRNEIEENK RLLYVAVTRA KEHLYFAVFS GSRMKHPLQR
     FETSGITVDT DADGKTSIDC LHTGISFRII ESEIEEFADN HQAELTYPAS HEYEKAIKIA
     ADACQAEKRD VLPSSADSKP GAVELVTEKL PRIRLGKIRD NEMAETGSCI HQIFCSLDRH
     KEDADQFITQ VINEWNQNVQ LPDRNGILVA WQNLTDWLNK QYGKPIKAYH ELPFKHFADG
     QIITGNMDLV WRTSKGCVLV DYKTFPGKSA LALQPGEHYA GNYKGQFDCY THALEAAGET
     VLARYVYYPV SGMVVKI
//