ID F8PMR0_SERL3 Unreviewed; 865 AA.
AC F8PMR0;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=beta-glucosidase {ECO:0000256|ARBA:ARBA00012744};
DE EC=3.2.1.21 {ECO:0000256|ARBA:ARBA00012744};
GN ORFNames=SERLA73DRAFT_158615 {ECO:0000313|EMBL:EGO02892.1};
OS Serpula lacrymans var. lacrymans (strain S7.3) (Dry rot fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Boletales; Coniophorineae; Serpulaceae; Serpula.
OX NCBI_TaxID=936435 {ECO:0000313|Proteomes:UP000008063};
RN [1] {ECO:0000313|Proteomes:UP000008063}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=strain S7.3 {ECO:0000313|Proteomes:UP000008063};
RX PubMed=21764756; DOI=10.1126/science.1205411;
RA Eastwood D.C., Floudas D., Binder M., Majcherczyk A., Schneider P.,
RA Aerts A., Asiegbu F.O., Baker S.E., Barry K., Bendiksby M., Blumentritt M.,
RA Coutinho P.M., Cullen D., de Vries R.P., Gathman A., Goodell B.,
RA Henrissat B., Ihrmark K., Kauserud H., Kohler A., LaButti K., Lapidus A.,
RA Lavin J.L., Lee Y.-H., Lindquist E., Lilly W., Lucas S., Morin E.,
RA Murat C., Oguiza J.A., Park J., Pisabarro A.G., Riley R., Rosling A.,
RA Salamov A., Schmidt O., Schmutz J., Skrede I., Stenlid J., Wiebenga A.,
RA Xie X., Kuees U., Hibbett D.S., Hoffmeister D., Hoegberg N., Martin F.,
RA Grigoriev I.V., Watkinson S.C.;
RT "The plant cell wall-decomposing machinery underlies the functional
RT diversity of forest fungi.";
RL Science 333:762-765(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal, non-reducing beta-D-glucosyl residues
CC with release of beta-D-glucose.; EC=3.2.1.21;
CC Evidence={ECO:0000256|ARBA:ARBA00000448};
CC -!- PATHWAY: Glycan metabolism; cellulose degradation.
CC {ECO:0000256|ARBA:ARBA00004987}.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 3 family.
CC {ECO:0000256|ARBA:ARBA00005336}.
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DR EMBL; GL945476; EGO02892.1; -; Genomic_DNA.
DR AlphaFoldDB; F8PMR0; -.
DR STRING; 936435.F8PMR0; -.
DR eggNOG; ENOG502QR4D; Eukaryota.
DR HOGENOM; CLU_004542_2_3_1; -.
DR InParanoid; F8PMR0; -.
DR OMA; VNDTYAC; -.
DR OrthoDB; 5486783at2759; -.
DR Proteomes; UP000008063; Unassembled WGS sequence.
DR GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 3.40.50.1700; Glycoside hydrolase family 3 C-terminal domain; 1.
DR Gene3D; 3.20.20.300; Glycoside hydrolase, family 3, N-terminal domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR026891; Fn3-like.
DR InterPro; IPR002772; Glyco_hydro_3_C.
DR InterPro; IPR036881; Glyco_hydro_3_C_sf.
DR InterPro; IPR001764; Glyco_hydro_3_N.
DR InterPro; IPR036962; Glyco_hydro_3_N_sf.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR013783; Ig-like_fold.
DR PANTHER; PTHR42715; BETA-GLUCOSIDASE; 1.
DR PANTHER; PTHR42715:SF10; BETA-GLUCOSIDASE F-RELATED; 1.
DR Pfam; PF14310; Fn3-like; 1.
DR Pfam; PF00933; Glyco_hydro_3; 1.
DR Pfam; PF01915; Glyco_hydro_3_C; 1.
DR PRINTS; PR00133; GLHYDRLASE3.
DR SMART; SM01217; Fn3_like; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF52279; Beta-D-glucan exohydrolase, C-terminal domain; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023001};
KW Cellulose degradation {ECO:0000256|ARBA:ARBA00023001};
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:EGO02892.1};
KW Polysaccharide degradation {ECO:0000256|ARBA:ARBA00023001};
KW Reference proteome {ECO:0000313|Proteomes:UP000008063}.
FT DOMAIN 785..854
FT /note="Fibronectin type III-like"
FT /evidence="ECO:0000259|SMART:SM01217"
SQ SEQUENCE 865 AA; 93557 MW; F9E64B70A63B0B3D CRC64;
MFYDRIKAVM AGKDGLGKAA VVTLHSAFCT RGTQCSRTVE LCNAHHGHRS SELAFVKAKG
VEHGDEHIFD RDLVVCLVVD AILCIDLNLN APFITFVASY IAPAIAPSAS FTHLVLSKHN
SFSSDPTLIP DFAPAWAAAY SKAKQHLADY TLEEKVNITT GVGWGNGLCV GNIPANKNFP
GLCLEDSPLA VRFADFVTAF PAGITTASTW NRALIRARGL ALGSEHKGKG VNVALGPMMN
MGRIAQGGRN WEGFGADPFL TGEAAYETIL GMQNGGVQAC AKHFINNEQE HMRTQDSANV
DDRTQHEIYA HPFLRSVMAG VSSVMCSYNL INDTYACNND KMINDILKRE YGFQGYVMSD
WQATMATLSA VAGLDMTMPG DITFDSGDSY FGGNLTAFVQ NGTISQARVD DMATRIIAGW
YYLHQESDYP EVSFNAFNTL DEATNKHVNV QSDHYKIVRE IGAAGSVLLK NERGALPLNK
PRNLILVGSD AGPGISGPNE FSDQGGSDRF LAMGWGSGTG LFPYLITPYE AIQERARQDG
SSIFWDFDDW NTANAQTLVT GQSAAIVFIN SDSGEDYITV DGNEGDRKNL TAWHNGDNLI
QAVASNNNNT IVVVNSVGPL IIEPWIEHPN VTAVVWASIG GQEGGNAIAD VLYGAYNPSG
RLPYTIAKSP ADYPAQLITG GSGSDILAIN YTEGLFIDYR HFDAANIEPR FEFGFGLSYT
TFEYSQVDIS AISSSDHPQQ SLIQAWENGD ATPIAEGSST ALWLHEPAFK VTFHVKNTGS
LSGTEIPQLY IHHPASAAEP PSVLKGFTNV KVSPGQTEHV SITLSRYDLS IWDVVAQGWR
KPSGEITFSV GASSRDFKLN GTIPT
//
