ID F8PNZ0_SERL3 Unreviewed; 516 AA.
AC F8PNZ0;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=DNA polymerase epsilon subunit {ECO:0000256|PIRNR:PIRNR000799};
DE AltName: Full=DNA polymerase II subunit 2 {ECO:0000256|PIRNR:PIRNR000799};
GN ORFNames=SERLA73DRAFT_177419 {ECO:0000313|EMBL:EGO01867.1};
OS Serpula lacrymans var. lacrymans (strain S7.3) (Dry rot fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Boletales; Coniophorineae; Serpulaceae; Serpula.
OX NCBI_TaxID=936435 {ECO:0000313|Proteomes:UP000008063};
RN [1] {ECO:0000313|Proteomes:UP000008063}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=strain S7.3 {ECO:0000313|Proteomes:UP000008063};
RX PubMed=21764756; DOI=10.1126/science.1205411;
RA Eastwood D.C., Floudas D., Binder M., Majcherczyk A., Schneider P.,
RA Aerts A., Asiegbu F.O., Baker S.E., Barry K., Bendiksby M., Blumentritt M.,
RA Coutinho P.M., Cullen D., de Vries R.P., Gathman A., Goodell B.,
RA Henrissat B., Ihrmark K., Kauserud H., Kohler A., LaButti K., Lapidus A.,
RA Lavin J.L., Lee Y.-H., Lindquist E., Lilly W., Lucas S., Morin E.,
RA Murat C., Oguiza J.A., Park J., Pisabarro A.G., Riley R., Rosling A.,
RA Salamov A., Schmidt O., Schmutz J., Skrede I., Stenlid J., Wiebenga A.,
RA Xie X., Kuees U., Hibbett D.S., Hoffmeister D., Hoegberg N., Martin F.,
RA Grigoriev I.V., Watkinson S.C.;
RT "The plant cell wall-decomposing machinery underlies the functional
RT diversity of forest fungi.";
RL Science 333:762-765(2011).
CC -!- FUNCTION: Participates in DNA repair and in chromosomal DNA
CC replication. {ECO:0000256|PIRNR:PIRNR000799}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR000799}.
CC -!- SIMILARITY: Belongs to the DNA polymerase epsilon subunit B family.
CC {ECO:0000256|ARBA:ARBA00009560, ECO:0000256|PIRNR:PIRNR000799}.
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DR EMBL; GL945477; EGO01867.1; -; Genomic_DNA.
DR AlphaFoldDB; F8PNZ0; -.
DR STRING; 936435.F8PNZ0; -.
DR eggNOG; KOG3818; Eukaryota.
DR HOGENOM; CLU_010628_2_1_1; -.
DR InParanoid; F8PNZ0; -.
DR OMA; FFCEGCF; -.
DR OrthoDB; 166885at2759; -.
DR Proteomes; UP000008063; Unassembled WGS sequence.
DR GO; GO:0008622; C:epsilon DNA polymerase complex; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR Gene3D; 3.60.21.50; -; 1.
DR InterPro; IPR007185; DNA_pol_a/d/e_bsu.
DR InterPro; IPR016266; POLE2.
DR PANTHER; PTHR12708:SF0; DNA POLYMERASE EPSILON SUBUNIT 2; 1.
DR PANTHER; PTHR12708; DNA POLYMERASE EPSILON SUBUNIT B; 1.
DR Pfam; PF04042; DNA_pol_E_B; 1.
DR PIRSF; PIRSF000799; DNA_pol_eps_2; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|PIRNR:PIRNR000799};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR000799};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR000799};
KW Reference proteome {ECO:0000313|Proteomes:UP000008063}.
FT DOMAIN 291..498
FT /note="DNA polymerase alpha/delta/epsilon subunit B"
FT /evidence="ECO:0000259|Pfam:PF04042"
SQ SEQUENCE 516 AA; 58617 MW; 1B18D57C494DCA3A CRC64;
MADARQRIII KVFRKYSHSL GPEALDFLEH ILTEHEIDDD DIEMSVETIA KEYNKQDDAS
MKVSLKVLRR VYETLQDQGS NPGEPEAELL DPESHLYFID AFEMPLWHWS VERGTFEKAQ
NLLTISGSAD SRVLAMRNRL HIIKQSILRN EHFAPSTLPS RDREHLVTLK STKQLLGRPG
ERFLLLGMLA RNMEGKLCVE DSDGSAELDL SRLEEPGEGL YTEGCFALVE GEYTEDGTLE
VVAMGQPPCE DRDTTRSIYG HIDFLGKGST TLLEDSQYSR RIRGELSDLY FFFLSDVWLD
HPKTFTGLQK MLDNCVENSF IPKVIVLCGN FTSRSISQGS ARDIQRYQEN FDALADLLAS
YSQITRTTHF VFVPGPLDII NNGALPRRPL LSSFVSRIKA KVPKAHFASN PCRLKFFGQE
IVIFREDTMA RMLRNTVGIK PNISGDDLRR YLVQSILDQS HLLPLTSNIQ PTLPDYDHAL
RLYPLPTTLV LADKYEKYKL TYSGCHVLNP GSFIES
//
