ID   F8PP47_SERL3            Unreviewed;       450 AA.
AC   F8PP47;
DT   21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT   21-SEP-2011, sequence version 1.
DT   27-MAR-2024, entry version 44.
DE   RecName: Full=COP9 signalosome complex subunit 4 {ECO:0000256|ARBA:ARBA00014881};
GN   ORFNames=SERLA73DRAFT_177559 {ECO:0000313|EMBL:EGO01924.1};
OS   Serpula lacrymans var. lacrymans (strain S7.3) (Dry rot fungus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Agaricomycetidae; Boletales; Coniophorineae; Serpulaceae; Serpula.
OX   NCBI_TaxID=936435 {ECO:0000313|Proteomes:UP000008063};
RN   [1] {ECO:0000313|Proteomes:UP000008063}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=strain S7.3 {ECO:0000313|Proteomes:UP000008063};
RX   PubMed=21764756; DOI=10.1126/science.1205411;
RA   Eastwood D.C., Floudas D., Binder M., Majcherczyk A., Schneider P.,
RA   Aerts A., Asiegbu F.O., Baker S.E., Barry K., Bendiksby M., Blumentritt M.,
RA   Coutinho P.M., Cullen D., de Vries R.P., Gathman A., Goodell B.,
RA   Henrissat B., Ihrmark K., Kauserud H., Kohler A., LaButti K., Lapidus A.,
RA   Lavin J.L., Lee Y.-H., Lindquist E., Lilly W., Lucas S., Morin E.,
RA   Murat C., Oguiza J.A., Park J., Pisabarro A.G., Riley R., Rosling A.,
RA   Salamov A., Schmidt O., Schmutz J., Skrede I., Stenlid J., Wiebenga A.,
RA   Xie X., Kuees U., Hibbett D.S., Hoffmeister D., Hoegberg N., Martin F.,
RA   Grigoriev I.V., Watkinson S.C.;
RT   "The plant cell wall-decomposing machinery underlies the functional
RT   diversity of forest fungi.";
RL   Science 333:762-765(2011).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC       Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the CSN4 family.
CC       {ECO:0000256|ARBA:ARBA00010417}.
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DR   EMBL; GL945477; EGO01924.1; -; Genomic_DNA.
DR   AlphaFoldDB; F8PP47; -.
DR   STRING; 936435.F8PP47; -.
DR   eggNOG; KOG1497; Eukaryota.
DR   HOGENOM; CLU_028132_1_1_1; -.
DR   InParanoid; F8PP47; -.
DR   OMA; WVAEIDE; -.
DR   OrthoDB; 5476188at2759; -.
DR   Proteomes; UP000008063; Unassembled WGS sequence.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR040134; PSMD12/CSN4.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR10855; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4; 1.
DR   PANTHER; PTHR10855:SF2; COP9 SIGNALOSOME COMPLEX SUBUNIT 4; 1.
DR   Pfam; PF01399; PCI; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000008063}.
FT   DOMAIN          268..385
FT                   /note="PCI"
FT                   /evidence="ECO:0000259|Pfam:PF01399"
FT   REGION          391..413
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   450 AA;  50047 MW;  A6B4281E95D96D58 CRC64;
     MESKLVQFSS LSQKDKAPAY LSLIPEVLSQ SDQPAIAANL HTLVDTVVNQ ESVGLVIGRQ
     VLSEIVKNLE AGAIPSSGLR KRIVEDTLAT IQPHIVSYEE QVNSLRYQLA DLLESEEEWS
     EAARVLMGIS VDSGQRALPD EEKLRLYIRI VRLLLEEEDS VQAETYYNRA ASVVHSTNDK
     ETLLQFKLCQ ARISDYARKF LEAAMRYHEL SWVAEIDEEE RREILSAAVT CAVLAPAGPN
     RSRVLASLYR DERSAELPTF NILSKMFLDH ILRPAEIKSF EEKLRPHQLA KIAISSNDQL
     ASTIDDDDLS EPNASTRRGP ATVLDRAVME HNLLASSKIY NNITFRGLGG LLDLTPGAAE
     TMARKMIEQG RLKGFIDQVD KLIWFDDGKE EDDAQGKAGG LGDVEQSTED TGAPFTKRWD
     MQIRMTAANV DSIVQHLAEK GLVNMVDVAA
//