ID   F8PTH6_SERL3            Unreviewed;       566 AA.
AC   F8PTH6;
DT   21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT   21-SEP-2011, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   RecName: Full=3'-5' exonuclease {ECO:0000256|ARBA:ARBA00040531};
DE   AltName: Full=Werner Syndrome-like exonuclease {ECO:0000256|ARBA:ARBA00042761};
GN   ORFNames=SERLA73DRAFT_71976 {ECO:0000313|EMBL:EGO01004.1};
OS   Serpula lacrymans var. lacrymans (strain S7.3) (Dry rot fungus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Agaricomycetidae; Boletales; Coniophorineae; Serpulaceae; Serpula.
OX   NCBI_TaxID=936435 {ECO:0000313|Proteomes:UP000008063};
RN   [1] {ECO:0000313|Proteomes:UP000008063}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=strain S7.3 {ECO:0000313|Proteomes:UP000008063};
RX   PubMed=21764756; DOI=10.1126/science.1205411;
RA   Eastwood D.C., Floudas D., Binder M., Majcherczyk A., Schneider P.,
RA   Aerts A., Asiegbu F.O., Baker S.E., Barry K., Bendiksby M., Blumentritt M.,
RA   Coutinho P.M., Cullen D., de Vries R.P., Gathman A., Goodell B.,
RA   Henrissat B., Ihrmark K., Kauserud H., Kohler A., LaButti K., Lapidus A.,
RA   Lavin J.L., Lee Y.-H., Lindquist E., Lilly W., Lucas S., Morin E.,
RA   Murat C., Oguiza J.A., Park J., Pisabarro A.G., Riley R., Rosling A.,
RA   Salamov A., Schmidt O., Schmutz J., Skrede I., Stenlid J., Wiebenga A.,
RA   Xie X., Kuees U., Hibbett D.S., Hoffmeister D., Hoegberg N., Martin F.,
RA   Grigoriev I.V., Watkinson S.C.;
RT   "The plant cell wall-decomposing machinery underlies the functional
RT   diversity of forest fungi.";
RL   Science 333:762-765(2011).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   EMBL; GL945478; EGO01004.1; -; Genomic_DNA.
DR   AlphaFoldDB; F8PTH6; -.
DR   STRING; 936435.F8PTH6; -.
DR   eggNOG; KOG4373; Eukaryota.
DR   HOGENOM; CLU_038394_0_0_1; -.
DR   InParanoid; F8PTH6; -.
DR   OMA; RCTHAYD; -.
DR   OrthoDB; 1365249at2759; -.
DR   Proteomes; UP000008063; Unassembled WGS sequence.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006139; P:nucleobase-containing compound metabolic process; IEA:InterPro.
DR   CDD; cd06141; WRN_exo; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   PANTHER; PTHR13620; 3-5 EXONUCLEASE; 1.
DR   PANTHER; PTHR13620:SF109; WERNER SYNDROME-LIKE EXONUCLEASE; 1.
DR   Pfam; PF01612; DNA_pol_A_exo1; 1.
DR   SMART; SM00474; 35EXOc; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008063}.
FT   DOMAIN          249..426
FT                   /note="3'-5' exonuclease"
FT                   /evidence="ECO:0000259|SMART:SM00474"
FT   REGION          31..50
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          62..118
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          158..225
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          435..467
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        158..184
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   566 AA;  63035 MW;  DDC9E95E6F4A418A CRC64;
     MTPKYRVLAS PPRIGSRAKE FSRCTHAYDK FAQAQESQQE PKDDSSDSSI EIIDVVFAPK
     KKEDTKAYSS RPIHPFFLKN NPREAATKTH KDFAGQHTKT TSTKQREGAG AAAVTSKKRE
     FKNAAATNTD DPYNACSPGD DLFLPLYADK TENLESFSRP ISTSLTGDPT DNTSSEQSPT
     GGTDLPTIPP RKVKKNPATK LSNLKNTPAS DIIGEKSPKT YIPQDSSNEH IKSILPLYSY
     LDYSPKASAV YIKNEEQANE LVKTLEGPLG FDLEWRVMWS AGAAERRTAL VQLCDRNTIL
     LIQVSAMKRF PQGVLDIIES PSVVKTGANI LNDGEKLFRD FGIHARNLVE LGSLARQADP
     RFVTVYNRQI VSLAKMVAMY LHKTLKKGKE RTANWEGVLN SKMIEYAASD AHCALMVHER
     LIHIAAKAGR ALDPSASTSV VNTDRSSKLN QTSRTISNSS QGSGSTQFSR TSFAVAYNEP
     PRPQHLRAFN LWHHRKMPLK EMCMTLKSKD RAEPLKESTV ISYVIGALQA DTSLPFNMDK
     LKELVRMESS SWQRHRQWIL ENGSRS
//