ID F8Q102_SERL3 Unreviewed; 440 AA.
AC F8Q102;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein {ECO:0000259|Pfam:PF01073};
GN ORFNames=SERLA73DRAFT_56469 {ECO:0000313|EMBL:EGN97980.1};
OS Serpula lacrymans var. lacrymans (strain S7.3) (Dry rot fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Boletales; Coniophorineae; Serpulaceae; Serpula.
OX NCBI_TaxID=936435 {ECO:0000313|Proteomes:UP000008063};
RN [1] {ECO:0000313|Proteomes:UP000008063}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=strain S7.3 {ECO:0000313|Proteomes:UP000008063};
RX PubMed=21764756; DOI=10.1126/science.1205411;
RA Eastwood D.C., Floudas D., Binder M., Majcherczyk A., Schneider P.,
RA Aerts A., Asiegbu F.O., Baker S.E., Barry K., Bendiksby M., Blumentritt M.,
RA Coutinho P.M., Cullen D., de Vries R.P., Gathman A., Goodell B.,
RA Henrissat B., Ihrmark K., Kauserud H., Kohler A., LaButti K., Lapidus A.,
RA Lavin J.L., Lee Y.-H., Lindquist E., Lilly W., Lucas S., Morin E.,
RA Murat C., Oguiza J.A., Park J., Pisabarro A.G., Riley R., Rosling A.,
RA Salamov A., Schmidt O., Schmutz J., Skrede I., Stenlid J., Wiebenga A.,
RA Xie X., Kuees U., Hibbett D.S., Hoffmeister D., Hoegberg N., Martin F.,
RA Grigoriev I.V., Watkinson S.C.;
RT "The plant cell wall-decomposing machinery underlies the functional
RT diversity of forest fungi.";
RL Science 333:762-765(2011).
CC -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC {ECO:0000256|ARBA:ARBA00009219}.
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DR EMBL; GL945481; EGN97980.1; -; Genomic_DNA.
DR AlphaFoldDB; F8Q102; -.
DR STRING; 936435.F8Q102; -.
DR eggNOG; KOG1430; Eukaryota.
DR HOGENOM; CLU_007383_6_8_1; -.
DR InParanoid; F8Q102; -.
DR OMA; AYEAFGY; -.
DR OrthoDB; 1133at2759; -.
DR Proteomes; UP000008063; Unassembled WGS sequence.
DR GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR PANTHER; PTHR43245:SF51; SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2; 1.
DR Pfam; PF01073; 3Beta_HSD; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000008063}.
FT DOMAIN 10..225
FT /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF01073"
SQ SEQUENCE 440 AA; 48023 MW; 287881DA1BD90FAA CRC64;
MSGQQKDVYL VIGGSGFVGR NIVEQLLARG DIVSVFDIVQ RHHDVPFYSG DITEESQLIE
AIQKSGTTCI IHTASPQHGA KDSSIYYKVN VDGTKAVIAA AVATGARKLV YTSSAGVVFD
GGDCINIDER VPYPEQPFDE YNDSKAKGEA LILAANGKGG LLTVALRPAG IFGPGDRQVM
QGLYQAYQRG QTHFQVGDNN NLFDYTYVGN VALAHLVAAD KLVPSQSADS DKTDWNSDTA
TLSGKEDSLL ATALPAVTAT TGYRRVPTCE ARPLGPYVAP PPNADQILAA YNAPPPTTTN
RPVVRHRFDQ FSENALALAP SSPLQVAGQA FFITNGEPVY FWDFMRLIWL QLDPPGSKRA
DHRIYVIPRA FGMVLGYLAE TWASVIGKEA GFTRYRVGYS CATRYHNIEK ARRVLGYEPQ
VGLEEGVRRM VEVRITFQHC
//
