ID F8QEB3_SERL3 Unreviewed; 1182 AA.
AC F8QEB3;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=VIT domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=SERLA73DRAFT_156401 {ECO:0000313|EMBL:EGN93488.1};
OS Serpula lacrymans var. lacrymans (strain S7.3) (Dry rot fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Boletales; Coniophorineae; Serpulaceae; Serpula.
OX NCBI_TaxID=936435 {ECO:0000313|Proteomes:UP000008063};
RN [1] {ECO:0000313|Proteomes:UP000008063}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=strain S7.3 {ECO:0000313|Proteomes:UP000008063};
RX PubMed=21764756; DOI=10.1126/science.1205411;
RA Eastwood D.C., Floudas D., Binder M., Majcherczyk A., Schneider P.,
RA Aerts A., Asiegbu F.O., Baker S.E., Barry K., Bendiksby M., Blumentritt M.,
RA Coutinho P.M., Cullen D., de Vries R.P., Gathman A., Goodell B.,
RA Henrissat B., Ihrmark K., Kauserud H., Kohler A., LaButti K., Lapidus A.,
RA Lavin J.L., Lee Y.-H., Lindquist E., Lilly W., Lucas S., Morin E.,
RA Murat C., Oguiza J.A., Park J., Pisabarro A.G., Riley R., Rosling A.,
RA Salamov A., Schmidt O., Schmutz J., Skrede I., Stenlid J., Wiebenga A.,
RA Xie X., Kuees U., Hibbett D.S., Hoffmeister D., Hoegberg N., Martin F.,
RA Grigoriev I.V., Watkinson S.C.;
RT "The plant cell wall-decomposing machinery underlies the functional
RT diversity of forest fungi.";
RL Science 333:762-765(2011).
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DR EMBL; GL945492; EGN93488.1; -; Genomic_DNA.
DR AlphaFoldDB; F8QEB3; -.
DR STRING; 936435.F8QEB3; -.
DR eggNOG; ENOG502QRPK; Eukaryota.
DR HOGENOM; CLU_003826_0_0_1; -.
DR InParanoid; F8QEB3; -.
DR OMA; ITAKCAQ; -.
DR OrthoDB; 4178950at2759; -.
DR Proteomes; UP000008063; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013694; VIT.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR45737; VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A; 1.
DR PANTHER; PTHR45737:SF6; VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN DDB_G0286969-RELATED; 1.
DR Pfam; PF08487; VIT; 1.
DR Pfam; PF13768; VWA_3; 1.
DR SMART; SM00609; VIT; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS51468; VIT; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008063};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 959..978
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1007..1034
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1046..1065
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1115..1139
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 6..136
FT /note="VIT"
FT /evidence="ECO:0000259|PROSITE:PS51468"
FT DOMAIN 276..478
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 640..671
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 709..735
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 749..782
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 641..656
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 657..671
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1182 AA; 130083 MW; 74EBEEEB1A21EDF8 CRC64;
MSSYAGIVHR PADQQGLVHL PLEQVIVEAW IVDVSARVQL SQLFVNPSDA PTGRAKYVFP
IPARAAVCAF ELKHADGKII RGTAKEKSEA NQTFNSAIQA GNMAGLVEWV TDDIFTISVG
SIPAKETVTS KLTFVMDLMD DGIRDHVRLQ LPVSIGMRYG EVPAAMVNAQ AAAEQTRIHI
SVDVQMSEEI YDIRSPSHEI KVLRYKTRIG KKSMRRKSAL WSSPTFMERD FVLTVHSHGL
DNARCFAEID PMGSNSVAMQ LTLVPRFKMP RVSSQEYIFV VDRSGSMGGG RIETAKSTLS
MLLRLLPNDN TLFNIFSFGS TVDGLWQNSV LYNQNALSQA VRIWYNPLDL SGLTFLKTSH
IRSMDANYGG TEIANALTGA LTSRRRDRST VAFILTDGES SDLHKTFSVV RNALSAANPN
CPLRVFTLGI GEQVSTAMCE GIARAGNGEC LLAVTTESIT AKCAQLLRAG RTRLIEHISV
HWHGSGTPPS VSFSEPRTGI SSASTSMVQL VPPPTIQQAP YQITKIYPGM RFIVFAITTY
STVPAEVKLC AKIEGEFDEV DLIVPVIEVK RFKHAKTNVP LIHTLAARRL ITDLEDDRAP
LPAVVGIAPS GDVIKKAAIV RLGLRYQLLS QYTSFVAVET GKEAERGRRR RDSSATSSRR
TQQQDSSQNG YGIFDSVIQG LSQVVSSVFD FPQPPMTYQT MKDDISGIPG SFVPAAASSS
SVDEPRRRHS REESDYDSIY TFSTLSSLEG SSSSRWTRSR TPSPPPPLEN LPDRSPSPAF
DISGTVPLIS TAPPPIPSTV YELFQLQNFD GSFTLSNNFA TIVGHDAARK GAELNVEETL
WATALAVAFL ETQLGSEPDL LECLQSKAMD YAKRRQLHRN FEDVVKIARR MITSHLERCT
AQYIDIKDSL TAPYVTEWTY AGLGPTNDAI DKMTCRCGVT ALPAISQPIP NMPTATTPLP
LSTLVPAINA NAIGLYGLTT TQASRKFRVA YLYWDRYPND SQWTRSLVVL LFVLNTAHAV
VVCHSCYYHV IVALLEPSIL LRNVCYVYKV MVATIVMSYY IKIIFQYACV RMFLISNGED
EIGFVHSTTF PALVFQTVSD ALIAASMTRD LIKALMLYAV GRGLVTSLTT FAMVLAIAIS
PDNLWMGQAA IYPGNKHRNV EFISLDAKEV TVKNNEQVKP NQ
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