ID F8TC38_9ALPH Unreviewed; 423 AA.
AC F8TC38;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Virion host shutoff protein {ECO:0000256|ARBA:ARBA00018606};
GN Name=UL41 {ECO:0000313|EMBL:AEI00249.1};
OS Gallid alphaherpesvirus 3.
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Orthoherpesviridae; Alphaherpesvirinae; Mardivirus;
OC Mardivirus gallidalpha3.
OX NCBI_TaxID=35250 {ECO:0000313|EMBL:AEI00249.1, ECO:0000313|Proteomes:UP000095860};
RN [1] {ECO:0000313|EMBL:AEI00249.1, ECO:0000313|Proteomes:UP000095860}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB-1 {ECO:0000313|EMBL:AEI00249.1};
RX PubMed=21336949; DOI=10.1007/s11262-011-0573-0;
RA Spatz S.J., Schat K.A.;
RT "Comparative genomic sequence analysis of the Marek's disease vaccine
RT strain SB-1.";
RL Virus Genes 42:331-338(2011).
RN [2] {ECO:0000313|EMBL:QEY02244.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=301B/1 {ECO:0000313|EMBL:QEY02244.1};
RA Kim T., Volkening J.D., Spatz S.J.;
RT "Genomic sequence analysis of Gallid alphaherpesvirus 3 strain 301B/1.";
RL Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000256|ARBA:ARBA00004328}.
CC -!- SIMILARITY: Belongs to the herpesviridae VHS protein family.
CC {ECO:0000256|ARBA:ARBA00009669}.
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DR EMBL; HQ840738; AEI00249.1; -; Genomic_DNA.
DR EMBL; MH939248; QEY02244.1; -; Genomic_DNA.
DR Proteomes; UP000095860; Genome.
DR GO; GO:0044423; C:virion component; IEA:UniProtKB-KW.
DR GO; GO:0004518; F:nuclease activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0039595; P:induction by virus of catabolism of host mRNA; IEA:UniProtKB-KW.
DR GO; GO:0039657; P:suppression by virus of host gene expression; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR InterPro; IPR006086; XPG-I_dom.
DR Pfam; PF00867; XPG_I; 1.
DR SUPFAM; SSF88723; PIN domain-like; 1.
PE 3: Inferred from homology;
KW Decay of host mRNAs by virus {ECO:0000256|ARBA:ARBA00022616};
KW Eukaryotic host gene expression shutoff by virus
KW {ECO:0000256|ARBA:ARBA00023247};
KW Host gene expression shutoff by virus {ECO:0000256|ARBA:ARBA00022995};
KW Host mRNA suppression by virus {ECO:0000256|ARBA:ARBA00022557};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW Virion {ECO:0000256|ARBA:ARBA00022844}.
FT DOMAIN 167..210
FT /note="XPG-I"
FT /evidence="ECO:0000259|Pfam:PF00867"
FT REGION 116..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 116..132
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 423 AA; 47993 MW; E2187CF8D393AC57 CRC64;
MGVYGCMHFA YANGLVRSHI SGSISGGAMT PIAVDLWNVM YGLLEKIYPG KVDGVDNSVA
TLRCLYCLLR LLHQRSYYPV FVSDRGFSKY GKTLYGAKAL AATRIARGGG SGRLQVRSRD
ECENADTGEA RNKRTRKRKR PRRWSDKSDT PKILHRLCMD TIRYMGYPYV DVAMMEADDI
CANLFHTKTV AYVLSSDTDM LLMGCDIIID LTRIFPPTIY CRDVLAALKM DYFTFLSNFV
RCQTDLHCEH TLKSMQEIID LGTLKQGSGT ICGKASDNER GRSSLMNCCN PEITGGHHYE
RPADMPDANR DLASNYSLLR SLHPPKTRCE VLEYKFIKHV IATIMPERRT PRISILKRFP
IMQDIRDDVA VEELVFRSIP NEAEASVIST AFLRCIPEVR PFDSVLIRYW GRDASQTTRC
EKR
//
