ID F8VPV8_MOUSE Unreviewed; 1318 AA.
AC F8VPV8;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Tetratricopeptide repeat domain 41 {ECO:0000313|Ensembl:ENSMUSP00000075059.7};
GN Name=Ttc41 {ECO:0000313|Ensembl:ENSMUSP00000075059.7,
GN ECO:0000313|MGI:MGI:2387653};
GN Synonyms=BC030307 {ECO:0000313|MGI:MGI:2387653};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000075059.7, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000075059.7, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000075059.7,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000075059.7}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000075059.7};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; NP_001003910.2; NM_001003910.2.
DR RefSeq; XP_006513058.1; XM_006512995.3.
DR RefSeq; XP_006513059.1; XM_006512996.3.
DR RefSeq; XP_006513060.1; XM_006512997.3.
DR RefSeq; XP_006513061.1; XM_006512998.2.
DR RefSeq; XP_006513062.1; XM_006512999.3.
DR RefSeq; XP_017169246.1; XM_017313757.1.
DR SMR; F8VPV8; -.
DR MaxQB; F8VPV8; -.
DR ProteomicsDB; 309822; -.
DR DNASU; 103220; -.
DR Ensembl; ENSMUST00000075632.14; ENSMUSP00000075059.7; ENSMUSG00000044937.16.
DR GeneID; 103220; -.
DR KEGG; mmu:103220; -.
DR UCSC; uc007gqk.1; mouse.
DR AGR; MGI:2387653; -.
DR CTD; 103220; -.
DR MGI; MGI:2387653; Ttc41.
DR VEuPathDB; HostDB:ENSMUSG00000044937; -.
DR GeneTree; ENSGT00530000064216; -.
DR HOGENOM; CLU_260771_0_0_1; -.
DR OMA; QIHPNTI; -.
DR OrthoDB; 51102at2759; -.
DR PhylomeDB; F8VPV8; -.
DR TreeFam; TF342161; -.
DR BioGRID-ORCS; 103220; 5 hits in 77 CRISPR screens.
DR ChiTaRS; Ttc41; mouse.
DR Proteomes; UP000000589; Chromosome 10.
DR Bgee; ENSMUSG00000044937; Expressed in spermatid and 106 other cell types or tissues.
DR ExpressionAtlas; F8VPV8; baseline and differential.
DR Genevisible; F8VPV8; MM.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR19860; DDB1- AND CUL4-ASSOCIATED FACTOR 12-RELATED; 1.
DR PANTHER; PTHR19860:SF18; FIRST GENE UPSTREAM OF NT5DC3; 1.
DR Pfam; PF05729; NACHT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 338..512
FT /note="NACHT"
FT /evidence="ECO:0000259|Pfam:PF05729"
SQ SEQUENCE 1318 AA; 150780 MW; 303A3965935255D4 CRC64;
MSDEASETGQ RYNGQPILKR QKPILPYICS TLDFQEERDF LAKSIFPRLN DICSSRGTYF
KAVDLRWSAV KAHKSFTSNQ FRQYSCLQSQ HLKLSLDYVN RCFPFFIGLL GQTYGDFLPD
YTPFLLSQVK DFESLSKGEQ NLYIAAKNGY PWVLKTPNCS LTEFEIIQAV FRKKSQFQFF
YFRTSNSLLR TFNEEEEEEE EKLSSAYLLN EQGKMKVGKL KAKIIGKGLP VRFYRDLEEL
GDMVWKDWSA VVEKLYPFTT IMGNIDYKHS FENLYHEEFV ENCKQVFVTS KESNRTFEIL
ERFAIKDLDL DLDTDSTIAG SGLDSILRIN SLPTCKSILL LSGERGCGKS TLIANWVSNF
QSKHPGVLMI PYFVGSTCES CDIMSVIHYF VMELQHRANG PRLEMDFLNE DSNVLVFSLL
VEVFIAAISL KPCILVLDGI EELIGIYGIS GQKAKDFSWL PRSLPPHCKF ILSSVSSSLS
CKSLCARPDV KIVELNSIGD EDTKFNIFRQ HLSPADQERF GQSKPILRKK PNLSPLKLAI
IASELQECKI YRNEFQCLRE YLEVASVQEL WELILKRWVE DYSWTLKPKD TTLDTVIPGP
SGWVVDVLCL LCISHCGLAE DELLQLLDTM GYRDHHKVTA VHWAAFRQAT KTWIQEKPNG
LLYFQHQSLR SAVEHKLLGV STPVRESNPN VAQNSVNHKK AHFHQVLMRF FQRQTIFWRV
YQELPWHMKM SGYWEGLCNF ITNPSITDFI SKIQNPSLWT RLHLVHYWDV LLEAGNDVSE
AFLLSVAKIE GEQFQKLKKR TTLSVLECSL SEITAADKGR IILFIGSFLK LMGKINEAEK
LFLSAEDLLL QSPSMTEMLL RAQNAIGELY LEIGMTPKGL TYFQKAWSNL LRFTLSDLKI
SQELMKQKVK VMNNLAKSAP GEFLKENHVL EYATEISKYV TGNPRDHATM KYTEGVLMLA
SGNAALAKLK FQECLTIRRW LFGNKNILVG EIMEFLADLL FFLLGENEKS QKKQAIEYYK
QVIKIKEKAD TVATCKLVRK HLSISLSDTL CKLAGQLLSG DFCHHATMEA VSYLYRSLDL
RAAHLGPTHA SIEGILHLLR EIQRSRGRRS WPQSMNHLFP NGSRNGFSLW ENVPKLNFHS
AQSSDTVNTA MCMNIRRFQR VKSTQPSLVS DKPKYVPGKG KKTLAPILCK SAEEKFQRQA
SDSQIWNSPR RQPARKKAAC PLKTVSLIDK NGLVRLSRQS VSSAELDSRK GLITSICRQP
LQLPHNVDNP WKSISELVSE KWLFHTPQYC FTPQKPGFPR RSQIESKLLK TSDDPNKE
//
