ID F8W2N9_DANRE Unreviewed; 885 AA.
AC F8W2N9; A0A8M1RRX0;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=NF-X1-type zinc finger protein NFXL1 {ECO:0000313|RefSeq:XP_002666590.3};
DE SubName: Full=Nuclear transcription factor, X-box-binding-like 1 {ECO:0000313|Ensembl:ENSDARP00000124661};
GN Name=nfxl1 {ECO:0000313|Ensembl:ENSDARP00000124661,
GN ECO:0000313|RefSeq:XP_002666590.3,
GN ECO:0000313|ZFIN:ZDB-GENE-110411-178};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000124661};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000124661}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000124661};
RG Ensembl;
RL Submitted (JUL-2011) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSDARP00000124661, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000124661};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3] {ECO:0000313|RefSeq:XP_002666590.3}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_002666590.3};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the NFX1 family.
CC {ECO:0000256|ARBA:ARBA00007269}.
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DR EMBL; CR318612; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CU682347; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CU993818; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_002666590.3; XM_002666544.6.
DR STRING; 7955.ENSDARP00000124661; -.
DR PaxDb; 7955-ENSDARP00000124661; -.
DR Ensembl; ENSDART00000149088; ENSDARP00000124661; ENSDARG00000070127.
DR Ensembl; ENSDART00000149088.3; ENSDARP00000124661.1; ENSDARG00000070127.6.
DR GeneID; 100333008; -.
DR KEGG; dre:100333008; -.
DR AGR; ZFIN:ZDB-GENE-110411-178; -.
DR CTD; 152518; -.
DR ZFIN; ZDB-GENE-110411-178; nfxl1.
DR eggNOG; KOG1952; Eukaryota.
DR OMA; KCQSVCH; -.
DR OrthoDB; 1412at2759; -.
DR TreeFam; TF323611; -.
DR Proteomes; UP000000437; Chromosome 23.
DR Bgee; ENSDARG00000070127; Expressed in early embryo and 21 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IBA:GO_Central.
DR CDD; cd06008; NF-X1-zinc-finger; 5.
DR CDD; cd16697; RING-CH-C4HC3_NFXL1; 1.
DR InterPro; IPR034078; NFX1_fam.
DR InterPro; IPR000967; Znf_NFX1.
DR InterPro; IPR001841; Znf_RING.
DR PANTHER; PTHR12360:SF1; NF-X1-TYPE ZINC FINGER PROTEIN NFXL1; 1.
DR PANTHER; PTHR12360; NUCLEAR TRANSCRIPTION FACTOR, X-BOX BINDING 1 NFX1; 1.
DR Pfam; PF01422; zf-NF-X1; 11.
DR SMART; SM00438; ZnF_NFX; 10.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 1: Evidence at protein level;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Proteomics identification {ECO:0007829|PeptideAtlas:F8W2N9};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT TRANSMEM 852..871
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 124..184
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 1..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..45
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 885 AA; 97452 MW; 6F887F7759511983 CRC64;
MDPVWRQQGR GRGQGQGRGQ VTGNPSSGRA RGAVGSQVKA SSQSRFDEIQ KSDRAAAQRL
TTDTYSSSSE DEDDDDSEDG GKRGKILKSA LSPYASHTGD TDGRLLEQTR HYLHEVCQSG
GVTCLICIAS VRRTQPVWSC VGCYCIFHIT CIQKWAKDSI FLVSSVTDED FGKKDHPWPC
PKCRHEYSPH QTPTRYYCYC GKEAEPAPDP WLLPHSCGQV CGREFKPSCG HRCLLLCHPG
PCPPCPQMVS VSCLCGKSSR VPRRCSAKAW SCTKICGRKL PCRTHTCANT CHAGECAACP
RVSLQACACG RQRAERPCAS PEWHCDQVCG RPLSCGNHKC ERVCHAGVCG ECPRAGNRSC
SCGKTKSVLP CTVDVPTCGD TCGKNLDCGL HTCSMRCHRG ACETCRQEVE KTCRCGRYSK
LLPCHKEYLC ESKCNKTRAC SRHQCKRKCC PGNCPPCDMN CGRMLGCRNH KCPSVCHQGS
CYPCPEMVKV GCECGSTVIS VPCGRERSTK PPRCKELCKK PPSCHHASQE KHRCHFGPCP
PCKQPCQLTL AGCVHLCPAP CHDQVLVKAT DRANLAGPWE QPSTPAFVRT ALPCPPCLVP
IPTACLGEHE VSPVPCHARG PFSCGRLCGR TLSCGNHKCS LECHHVTPTP NSDKTMAGQE
CVRCEEGCVK PRPAGCAHPC VLPCHRSACP PCQLMLRQRC HCKISSLYIE CLKFTSADEQ
DKQLLMSCQN QCPKQLLCGH RCKLLCHAGD CDQNCGQKVK IRCPCKRIKK DFPCSRVQSQ
DGLLVCDETC QTLQKKHAEA CAAEERALLE GEMRKQQAEL EAFEKRQKGR RKKNRKVTEV
EMDEGVWHRY KLRLLLPFCG VLLAVAAFYL LKLTNEVTDS ESAGH
//
