GenomeNet

Database: UniProt
Entry: F8W3T1_DANRE
LinkDB: F8W3T1_DANRE
Original site: F8W3T1_DANRE 
ID   F8W3T1_DANRE            Unreviewed;       785 AA.
AC   F8W3T1;
DT   21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT   21-SEP-2011, sequence version 1.
DT   05-JUN-2019, entry version 60.
DE   SubName: Full=ADAM metallopeptidase domain 23a {ECO:0000313|Ensembl:ENSDARP00000124043};
GN   Name=adam23a {ECO:0000313|Ensembl:ENSDARP00000124043,
GN   ECO:0000313|ZFIN:ZDB-GENE-070810-2};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000124043, ECO:0000313|Proteomes:UP000000437};
RN   [1] {ECO:0000313|Ensembl:ENSDARP00000124043}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000124043};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000124043, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000124043,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
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DR   EMBL; CT009620; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_001923262.2; XM_001923227.6.
DR   STRING; 7955.ENSDARP00000124043; -.
DR   MEROPS; M12.979; -.
DR   PaxDb; F8W3T1; -.
DR   Ensembl; ENSDART00000150036; ENSDARP00000124043; ENSDARG00000062323.
DR   GeneID; 794175; -.
DR   KEGG; dre:794175; -.
DR   CTD; 794175; -.
DR   ZFIN; ZDB-GENE-070810-2; adam23a.
DR   eggNOG; KOG3607; Eukaryota.
DR   eggNOG; ENOG410XX2M; LUCA.
DR   GeneTree; ENSGT00940000158781; -.
DR   InParanoid; F8W3T1; -.
DR   KO; K06837; -.
DR   OrthoDB; 162519at2759; -.
DR   TreeFam; TF314733; -.
DR   Reactome; R-DRE-5682910; LGI-ADAM interactions.
DR   Proteomes; UP000000437; Chromosome 6.
DR   Bgee; ENSDARG00000062323; Expressed in 17 organ(s), highest expression level in brain.
DR   ExpressionAtlas; F8W3T1; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   CDD; cd04269; ZnMc_adamalysin_II_like; 1.
DR   Gene3D; 3.40.390.10; -; 1.
DR   Gene3D; 4.10.70.10; -; 1.
DR   InterPro; IPR006586; ADAM_Cys-rich.
DR   InterPro; IPR001762; Disintegrin_dom.
DR   InterPro; IPR036436; Disintegrin_dom_sf.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR   InterPro; IPR001590; Peptidase_M12B.
DR   InterPro; IPR002870; Peptidase_M12B_N.
DR   InterPro; IPR034027; Reprolysin_adamalysin.
DR   Pfam; PF08516; ADAM_CR; 1.
DR   Pfam; PF00200; Disintegrin; 1.
DR   Pfam; PF01562; Pep_M12B_propep; 1.
DR   Pfam; PF01421; Reprolysin; 1.
DR   SMART; SM00608; ACR; 1.
DR   SMART; SM00050; DISIN; 1.
DR   SUPFAM; SSF57552; SSF57552; 1.
DR   PROSITE; PS50215; ADAM_MEPRO; 1.
DR   PROSITE; PS50214; DISINTEGRIN_2; 1.
DR   PROSITE; PS00022; EGF_1; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00068,
KW   ECO:0000256|SAAS:SAAS00117091};
KW   Membrane {ECO:0000256|SAAS:SAAS01078504, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS01078486,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS01078482,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     22       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        23    785       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003379570.
FT   TRANSMEM    747    770       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      254    451       Peptidase M12B. {ECO:0000259|PROSITE:
FT                                PS50215}.
FT   DOMAIN      457    542       Disintegrin. {ECO:0000259|PROSITE:
FT                                PS50214}.
FT   REGION       32     62       Disordered. {ECO:0000256|MobiDB-lite:
FT                                F8W3T1}.
FT   COMPBIAS     39     59       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                F8W3T1}.
FT   DISULFID    514    534       {ECO:0000256|PROSITE-ProRule:PRU00068}.
SQ   SEQUENCE   785 AA;  86632 MW;  E4C8FDCCE9E94F37 CRC64;
     MRLIFHLCLL ASIIISVPSS IATSSTVSSS VQNEALRDQH VSETPREATA PDDSTEGKTG
     EHPVTITYPS RLIYYLNEES ESTFHDLDTR AKNQAGDGQD VHLAQASFQL DAFGTTFTLD
     LTLNNDLLSS DYIEIHYEND KPVLSRGGEH CYYHGHVRGK EDSRAALSTC NGLHGMFDDG
     NFVYLIEPQK QTHTAETEAR PHTLRRTSSL GLTSIPDDWT ADDPDEEKRI FASMPWLKRR
     RKRAMPRNIF EEMKYLEIMI VADHNTFKKH RSKKHTRNTA KSLVNLVDAI FKEQLNTRVV
     LVAVEIWTDK DRIPLSVKPL EMLKDFSKYR QQNININADA VHLFTNMTFH YGRSSVGYIG
     GVCSKARGIG VNEFGNTWTM AGFFSQSLAQ NLGIQWDPSL RRKECGCMDS WLGCIMEDTG
     VQHPRKFSKC SITDYRNFLL RGGASCLFNK PNKLFEATEC GNGYVEVGEE CDCGARMECY
     KDCCKKCSLS NGAHCSDGPC CNGTCLFYPR GYSCRFAVND CDISETCSGD SGQCPPNLHK
     QDGYSCQLNQ GRCYSGECKT RESQCKYIWG PKAGGSEKHC YEKLNTEGTE KGNCGRDGDK
     WVPCSKHDVF CGYLLCSSTG RIPRIGTLKG DVTPTTFNHQ GRLVDCSGGH VLLDDDTDLG
     YVEDGTPCGP SMMCLERKCL PISSLNLTAC PSGPGGRVCS SHGVCNNEAT CTCDATWAGT
     DCSMHDPPKE PPVIEDPGPK GPSATNLIIG SIAGAILMAA IVLGGTGWGF KNVKKRRYDP
     NASAI
//
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