ID F8W5Z7_DANRE Unreviewed; 1175 AA.
AC F8W5Z7; A0A8M3B5F4;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE SubName: Full=Thrombospondin 2a {ECO:0000313|Ensembl:ENSDARP00000124920};
DE SubName: Full=Thrombospondin-2 {ECO:0000313|RefSeq:XP_009305765.1};
GN Name=thbs2a {ECO:0000313|Ensembl:ENSDARP00000124920,
GN ECO:0000313|RefSeq:XP_009305765.1,
GN ECO:0000313|ZFIN:ZDB-GENE-020708-2};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000124920};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000124920}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000124920};
RG Ensembl;
RL Submitted (JUL-2011) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSDARP00000124920, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000124920};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3] {ECO:0000313|RefSeq:XP_009305765.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_009305765.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the thrombospondin family.
CC {ECO:0000256|ARBA:ARBA00009456}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; BX663524; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_009305765.1; XM_009307490.3.
DR PaxDb; 7955-ENSDARP00000124920; -.
DR Ensembl; ENSDART00000148481; ENSDARP00000124920; ENSDARG00000060410.
DR Ensembl; ENSDART00000148481.3; ENSDARP00000124920.1; ENSDARG00000060410.7.
DR GeneID; 100535241; -.
DR KEGG; dre:100535241; -.
DR AGR; ZFIN:ZDB-GENE-020708-2; -.
DR CTD; 100535241; -.
DR ZFIN; ZDB-GENE-020708-2; thbs2a.
DR HOGENOM; CLU_009257_0_0_1; -.
DR OrthoDB; 5345349at2759; -.
DR PhylomeDB; F8W5Z7; -.
DR TreeFam; TF324917; -.
DR Proteomes; UP000000437; Chromosome 13.
DR Bgee; ENSDARG00000060410; Expressed in swim bladder and 12 other cell types or tissues.
DR GO; GO:0062023; C:collagen-containing extracellular matrix; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0016525; P:negative regulation of angiogenesis; IBA:GO_Central.
DR CDD; cd00054; EGF_CA; 1.
DR Gene3D; 2.60.120.200; -; 2.
DR Gene3D; 6.20.200.20; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 3.
DR Gene3D; 4.10.1080.10; TSP type-3 repeat; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR003367; Thrombospondin_3-like_rpt.
DR InterPro; IPR017897; Thrombospondin_3_rpt.
DR InterPro; IPR008859; Thrombospondin_C.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR028974; TSP_type-3_rpt.
DR InterPro; IPR048287; TSPN-like_N.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR10199; THROMBOSPONDIN; 1.
DR PANTHER; PTHR10199:SF10; THROMBOSPONDIN-2; 1.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF00090; TSP_1; 3.
DR Pfam; PF02412; TSP_3; 6.
DR Pfam; PF05735; TSP_C; 1.
DR Pfam; PF00093; VWC; 1.
DR PRINTS; PR01705; TSP1REPEAT.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00209; TSP1; 3.
DR SMART; SM00210; TSPN; 1.
DR SMART; SM00214; VWC; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 2.
DR SUPFAM; SSF57603; FnI-like domain; 1.
DR SUPFAM; SSF103647; TSP type-3 repeat; 2.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 3.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS50092; TSP1; 3.
DR PROSITE; PS51234; TSP3; 4.
DR PROSITE; PS51236; TSP_CTER; 1.
DR PROSITE; PS01208; VWFC_1; 1.
DR PROSITE; PS50184; VWFC_2; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00634}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Heparin-binding {ECO:0000256|ARBA:ARBA00022674};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..1175
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041197556"
FT DOMAIN 322..379
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 651..695
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REPEAT 732..767
FT /note="TSP type-3"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00634"
FT REPEAT 791..826
FT /note="TSP type-3"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00634"
FT REPEAT 888..923
FT /note="TSP type-3"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00634"
FT REPEAT 924..959
FT /note="TSP type-3"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00634"
FT DOMAIN 963..1175
FT /note="TSP C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51236"
FT REGION 844..938
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 849..873
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 888..902
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 909..938
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1175 AA; 130273 MW; 07981FC90697071C CRC64;
MILRSNLCLW PLLLLCIRAL PQDGLVEDES IFDLFKISGI SRKTIGAKLF KGHDWDSPAY
RFIRFDHIPA VSTPALHQIL KQVQNNEGFV FVATMRQDKG SRGTLLGVEG PGGLRQLEIV
SNGRANTLDL VYMVKGSQNV VSFEDVDLSD SQWKNISLYV HGENAHLYVG CSLIDSVILD
EPFYELLRPE GSQMFVAKGS IRENHFRGLL QNVQFLFDTP IENILRNKGC EIAKPEEVNV
VNESTESVSV GTSISTNFIG EKEKIASDVC ERSCEELSNM VQELKGLRII VGNLIDGLQK
VTEENTVMKE VLGNMKNIKD KRMCWQDGRL FEDKEDWVVD SCTKCTCQES KIVCHQITCP
PVACASPTFL DGECCPLCLP KDSEDGWSPW SEWTECTVTC GTGTQQRGRS CDATSNPCSG
PSIQTRRCSL GKCDSRVRQD GGWSLWSPWS SCSVTCGEGQ ITRIRHCNSP VPQLGGKDCE
GSGRETQKCE AKPCPIDGAW GPWSPWAVCS VTCGGGTRTR TRVCNSPRPQ YGGKKCPGDS
VDTNACNKQD CPVDGCLSNP CFGGVECTSS PDGSWECGPC PLGFRGNGKV CEDVNECDMV
PDLCYKVGDS QRCVNTDPGF HCLPCPPRYK GNQPFGMGVE AAKLNKQVCE QENPCKEKTH
NCHRSAECIY LGHFSEPMFK CECKIGYAGD GLICGEDSDL DGWPNQNLVC GANQSYHCKK
DNCPKLPNSG QEDFDKDGQG DACDKDDDND GIMDETDNCP LLYNPRQFDY DKDLVGDRCD
NCPYEHNPAQ IDTDGNGEGD ACAVDIDGDE VLNENDNCPY MYNTDQKDTD MDGVGDQCDN
CPLLHNPEQT DSDNDRVGDE CDNNQDIDED GHQNSLDNCP YIPNANQADH DKDGKGDACD
SDDDNDGVPD DKDNCRLVPN KDQRDSDGDG RGDACKDDFD NDSIPDFMDV CPENDAISNT
DFRKFQMVHL DPKGTAQIDP NWVVRHQGKE LVQTANSDPG IAVGFDEFNA VDFSGTFYVN
TDRDDDYAGF VFGYQSSGRF YVVMWKQITQ TYWEDNPSKA IGISGVSLKV VNSTTGTGEH
LRNALWHTGD TPGQVRTLWH DPKNIGWKDY TAYRWHLIHR PKTGFIRVVV YEGKQIMADS
GPVYDQTFAG GRLGLFVFSQ ELVYFSDLKY ECRDN
//
