ID F8WCR6_HUMAN Unreviewed; 218 AA.
AC F8WCR6;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Adaptor related protein complex 4 subunit mu 1 {ECO:0000313|Ensembl:ENSP00000396928.1};
GN Name=AP4M1 {ECO:0000313|Ensembl:ENSP00000396928.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000396928.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000396928.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [2] {ECO:0000313|Ensembl:ENSP00000396928.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the adaptor complexes medium subunit family.
CC {ECO:0000256|ARBA:ARBA00005324}.
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DR EMBL; AC073842; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; F8WCR6; -.
DR SMR; F8WCR6; -.
DR MassIVE; F8WCR6; -.
DR MaxQB; F8WCR6; -.
DR PeptideAtlas; F8WCR6; -.
DR ProteomicsDB; 31244; -.
DR Ensembl; ENST00000446007.5; ENSP00000396928.1; ENSG00000221838.10.
DR UCSC; uc064fzq.1; human.
DR HGNC; HGNC:574; AP4M1.
DR VEuPathDB; HostDB:ENSG00000221838; -.
DR GeneTree; ENSGT00940000159929; -.
DR HOGENOM; CLU_026996_2_1_1; -.
DR ChiTaRS; AP4M1; human.
DR Proteomes; UP000005640; Chromosome 7.
DR Bgee; ENSG00000221838; Expressed in left testis and 111 other cell types or tissues.
DR ExpressionAtlas; F8WCR6; baseline and differential.
DR GO; GO:0030131; C:clathrin adaptor complex; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR CDD; cd14838; AP4_Mu_N; 1.
DR Gene3D; 3.30.450.60; -; 1.
DR InterPro; IPR022775; AP_mu_sigma_su.
DR InterPro; IPR001392; Clathrin_mu.
DR InterPro; IPR011012; Longin-like_dom_sf.
DR PANTHER; PTHR10529; AP COMPLEX SUBUNIT MU; 1.
DR PANTHER; PTHR10529:SF270; AP-4 COMPLEX SUBUNIT MU-1; 1.
DR Pfam; PF01217; Clat_adaptor_s; 1.
DR PRINTS; PR00314; CLATHRINADPT.
DR SUPFAM; SSF64356; SNARE-like; 1.
PE 1: Evidence at protein level;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Proteomics identification {ECO:0007829|EPD:F8WCR6,
KW ECO:0007829|MaxQB:F8WCR6};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Transport {ECO:0000256|ARBA:ARBA00022927}.
FT DOMAIN 5..130
FT /note="AP complex mu/sigma subunit"
FT /evidence="ECO:0000259|Pfam:PF01217"
SQ SEQUENCE 218 AA; 23961 MW; 988B651E00E4CF25 CRC64;
MISQFFILSS KGDPLIYKDF RGDSGGRDVA ELFYRKLTGL PGDESPVVMH HHGRHFIHIR
HSGLYLVVTT SENVSPFSLL ELLSRLATLL GDYCGSLGEG TISRNVALVY ELLDEVLDYG
YVQTTSTEML RNFIQTEAVV SKPFSLFDLS SVGLFGAETQ QSKVAPSSAA SRPVLSSRSD
QSQKNEVFLD VVERLSVLIA SNVMGQESGS MKSRFTAL
//
