ID F8WCU8_HUMAN Unreviewed; 91 AA.
AC F8WCU8;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE SubName: Full=Protein-glutamine gamma-glutamyltransferase 4 {ECO:0000313|Ensembl:ENSP00000487489};
DE SubName: Full=Transglutaminase 4 {ECO:0000313|Ensembl:ENSP00000403711.1};
GN Name=TGM4 {ECO:0000313|Ensembl:ENSP00000403711.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000403711.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000403711.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [2] {ECO:0000313|Ensembl:ENSP00000403711.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the transglutaminase superfamily.
CC Transglutaminase family. {ECO:0000256|ARBA:ARBA00005968}.
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DR EMBL; AC098649; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR ProteomicsDB; 31276; -.
DR Ensembl; ENST00000422219.5; ENSP00000403711.1; ENSG00000163810.13.
DR Ensembl; ENST00000627547; ENSP00000487489; ENSG00000281886.
DR UCSC; uc062iwh.1; human.
DR HGNC; HGNC:11780; TGM4.
DR VEuPathDB; HostDB:ENSG00000163810; -.
DR GeneTree; ENSGT01050000244939; -.
DR HOGENOM; CLU_2426419_0_0_1; -.
DR ChiTaRS; TGM4; human.
DR Proteomes; UP000005640; Chromosome 3.
DR Bgee; ENSG00000163810; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 74 other cell types or tissues.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR001102; Transglutaminase_N.
DR Pfam; PF00868; Transglut_N; 1.
DR SUPFAM; SSF81296; E set domains; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|PeptideAtlas:F8WCU8,
KW ECO:0007829|ProteomicsDB:F8WCU8};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 12..67
FT /note="Transglutaminase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00868"
SQ SEQUENCE 91 AA; 10667 MW; 5A82FF426B2DA7D8 CRC64;
MMDASKELQV LHIDFLNQDN AVSHHTWEFQ TSSPVFRRGQ VFHLRLVLNQ PLQSYHQLKL
EFSTGHSGCH QFPQCHPGQV PTKRENWKPH P
//
