ID F8WGD7_MOUSE Unreviewed; 413 AA.
AC F8WGD7;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE RecName: Full=Adenosine 3'-phospho 5'-phosphosulfate transporter 2 {ECO:0000256|ARBA:ARBA00039669};
GN Name=Slc35b3 {ECO:0000313|Ensembl:ENSMUSP00000021870.5,
GN ECO:0000313|MGI:MGI:1913978};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000021870.5, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000021870.5, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000021870.5,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000021870.5}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000021870.5};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. SLC35B
CC subfamily. {ECO:0000256|ARBA:ARBA00010694}.
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DR RefSeq; NP_001163902.1; NM_001170431.1.
DR AlphaFoldDB; F8WGD7; -.
DR SMR; F8WGD7; -.
DR SwissPalm; F8WGD7; -.
DR PeptideAtlas; F8WGD7; -.
DR ProteomicsDB; 367432; -.
DR Antibodypedia; 24732; 10 antibodies from 6 providers.
DR DNASU; 108652; -.
DR Ensembl; ENSMUST00000021870.12; ENSMUSP00000021870.5; ENSMUSG00000021432.16.
DR GeneID; 108652; -.
DR UCSC; uc011yyn.1; mouse.
DR AGR; MGI:1913978; -.
DR CTD; 51000; -.
DR MGI; MGI:1913978; Slc35b3.
DR VEuPathDB; HostDB:ENSMUSG00000021432; -.
DR GeneTree; ENSGT00940000157040; -.
DR OrthoDB; 614761at2759; -.
DR PhylomeDB; F8WGD7; -.
DR TreeFam; TF314523; -.
DR BioGRID-ORCS; 108652; 1 hit in 76 CRISPR screens.
DR ChiTaRS; Slc35b3; mouse.
DR Proteomes; UP000000589; Chromosome 13.
DR Bgee; ENSMUSG00000021432; Expressed in renal medulla collecting duct and 248 other cell types or tissues.
DR ExpressionAtlas; F8WGD7; baseline and differential.
DR Genevisible; F8WGD7; MM.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR InterPro; IPR013657; SCL35B1-4/HUT1.
DR PANTHER; PTHR10778:SF8; ADENOSINE 3'-PHOSPHO 5'-PHOSPHOSULFATE TRANSPORTER 2; 1.
DR PANTHER; PTHR10778; SOLUTE CARRIER FAMILY 35 MEMBER B; 1.
DR Pfam; PF08449; UAA; 1.
PE 1: Evidence at protein level;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|MaxQB:F8WGD7,
KW ECO:0007829|ProteomicsDB:F8WGD7};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 93..111
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 123..145
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 157..179
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 185..202
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 209..227
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 233..254
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 274..297
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 309..329
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 336..358
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 364..381
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..35
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 413 AA; 45651 MW; C60D9D28DE889931 CRC64;
MDRTLAQSTQ EQGGEAQPAE ERQDEASEKS RDQVAGLDCG RAETMDLKFN NSRKYVSISV
PSKTQAMSPH IKSVEDVVVL GVNLSKFSKL TQFLICVAGV FVFYLIYGYL QELIFSVEGF
KPYGWYLTLV QFAFYSVFGL IELQLTQDRR RRIPGKTYML IAFLTVGTMG LSNTSLGYLN
YPTQVIFKCC KLIPVMLGGV FIQGKRYNLA DVSAAVCMSL GLIWFTLADS TIAPNFNLTG
VMLISLALCA DAVIGNVQEK AMKLHNASNS EMVLYSYSIG FVYILLGLSC TSGLGPAVAF
CSKNPVGTYG YAFLFSLTGY FGISFVLALI KIFGALLAVT VTTGRKAMTV VLSFLFFAKP
FTFQYIWSGL LVVLGIFLNV YSKNMDKIRL PSVYNMIKKA MDMKKSRTLA QTV
//
