ID F8WIN2_MOUSE Unreviewed; 536 AA.
AC F8WIN2;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=AT-rich interactive domain-containing protein 3 {ECO:0000256|RuleBase:RU369100};
DE Short=ARID domain-containing protein {ECO:0000256|RuleBase:RU369100};
GN Name=Arid3b {ECO:0000313|Ensembl:ENSMUSP00000096283.4,
GN ECO:0000313|MGI:MGI:1930768};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000096283.4, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000096283.4, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000096283.4,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:24129315}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=24129315;
RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA Bedford M.T., Comb M.J.;
RT "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT methylation.";
RL Mol. Cell. Proteomics 13:372-387(2014).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000096283.4}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000096283.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Transcription factor. {ECO:0000256|RuleBase:RU369100}.
CC -!- SUBUNIT: Heterodimer with ARID3A. Interacts with unphosphorylated RB1.
CC {ECO:0000256|RuleBase:RU369100}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU369100}.
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DR AlphaFoldDB; F8WIN2; -.
DR SMR; F8WIN2; -.
DR EPD; F8WIN2; -.
DR MaxQB; F8WIN2; -.
DR PeptideAtlas; F8WIN2; -.
DR ProteomicsDB; 314299; -.
DR Antibodypedia; 26965; 228 antibodies from 23 providers.
DR Ensembl; ENSMUST00000098686.4; ENSMUSP00000096283.4; ENSMUSG00000004661.16.
DR UCSC; uc009pvu.1; mouse.
DR AGR; MGI:1930768; -.
DR MGI; MGI:1930768; Arid3b.
DR VEuPathDB; HostDB:ENSMUSG00000004661; -.
DR GeneTree; ENSGT00940000156052; -.
DR ChiTaRS; Arid3b; mouse.
DR Proteomes; UP000000589; Chromosome 9.
DR Bgee; ENSMUSG00000004661; Expressed in embryonic post-anal tail and 146 other cell types or tissues.
DR ExpressionAtlas; F8WIN2; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd16879; ARID_ARID3B; 1.
DR Gene3D; 1.10.150.60; ARID DNA-binding domain; 1.
DR InterPro; IPR045147; ARI3A/B/C.
DR InterPro; IPR001606; ARID_dom.
DR InterPro; IPR036431; ARID_dom_sf.
DR InterPro; IPR023334; REKLES_domain.
DR PANTHER; PTHR15348:SF3; AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 3B; 1.
DR PANTHER; PTHR15348; AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN ARID DOMAIN- CONTAINING PROTEIN DEAD RINGER PROTEIN B-CELL REGULATOR OF IGH TRANSCRIPTION BRIGHT; 1.
DR Pfam; PF01388; ARID; 1.
DR SMART; SM01014; ARID; 1.
DR SMART; SM00501; BRIGHT; 1.
DR SUPFAM; SSF46774; ARID-like; 1.
DR PROSITE; PS51011; ARID; 1.
DR PROSITE; PS51486; REKLES; 1.
PE 1: Evidence at protein level;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU369100};
KW Nucleus {ECO:0000256|RuleBase:RU369100};
KW Proteomics identification {ECO:0007829|EPD:F8WIN2,
KW ECO:0007829|PeptideAtlas:F8WIN2};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Transcription {ECO:0000256|RuleBase:RU369100};
KW Transcription regulation {ECO:0000256|RuleBase:RU369100}.
FT DOMAIN 213..305
FT /note="ARID"
FT /evidence="ECO:0000259|PROSITE:PS51011"
FT DOMAIN 425..522
FT /note="REKLES"
FT /evidence="ECO:0000259|PROSITE:PS51486"
FT REGION 1..174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 378..403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..22
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..59
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 86..107
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 536 AA; 58177 MW; C1D528F6292E168C CRC64;
MEPLQQQQQQ QQQKQPQQPL LQMDAREKQG PQTRESQFLY ASKLGTQPAL LSITPGRPSG
SSVLGPLARV PPATPVARMS EQSNVNSEPE EEEGGLEDED GDDDVAEVAE KEAQAASKYF
HMQKVTRQEP RATPMSSLLP VPGLSPQGQQ TKEDHTKDAS KAPPSVPTAG QPSWSLDEQL
KQNGALAWSD DADGGRGREI SRDFAKLYEL DGDPERKEFL DDLFIFMQKR GTPINRIPIM
AKQILDLYML YKLVTEKGGL VEIINKKIWR EITKGLNLPT SITSAAFTLR TQYMKYLYAY
ECEKKALSSP AELQAAIDGN RREGRRPSYS SSLFGYSPAA AAAAAAAAAA AAASAASAGT
PALLSSPKIR FSILGLGSSS GTSASSPRIP PASTLRKGDG VPVPVPNRLA VSGTLAGQQA
GNRPGPLEHL RERLESGEPP EKKASRLSEE EQRLVQQAFQ RNLFSMARQL PMKIRINGRE
DRAEPSAPAL NLTTSNIGSI NMSVDIDGTT YTGRPLELWK AHADWQPKCS FPVGPA
//
