ID F8WJ74_MOUSE Unreviewed; 688 AA.
AC F8WJ74;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=GRAM domain containing 1A {ECO:0000313|Ensembl:ENSMUSP00000082778.7};
GN Name=Gramd1a {ECO:0000313|Ensembl:ENSMUSP00000082778.7,
GN ECO:0000313|MGI:MGI:105490};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000082778.7, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000082778.7, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000082778.7,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000082778.7}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000082778.7};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004162};
CC Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}.
CC Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004389}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004389}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; F8WJ74; -.
DR SMR; F8WJ74; -.
DR MaxQB; F8WJ74; -.
DR PeptideAtlas; F8WJ74; -.
DR ProteomicsDB; 359482; -.
DR Antibodypedia; 2264; 104 antibodies from 16 providers.
DR Ensembl; ENSMUST00000085636.13; ENSMUSP00000082778.7; ENSMUSG00000001248.16.
DR AGR; MGI:105490; -.
DR MGI; MGI:105490; Gramd1a.
DR VEuPathDB; HostDB:ENSMUSG00000001248; -.
DR GeneTree; ENSGT00940000161007; -.
DR ChiTaRS; Gramd1a; mouse.
DR Proteomes; UP000000589; Chromosome 7.
DR Bgee; ENSMUSG00000001248; Expressed in embryonic brain and 254 other cell types or tissues.
DR ExpressionAtlas; F8WJ74; baseline and differential.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0044232; C:organelle membrane contact site; IEA:UniProt.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR CDD; cd13220; PH-GRAM_GRAMDC; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR004182; GRAM.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR031968; VASt.
DR PANTHER; PTHR23319:SF8; PROTEIN ASTER-A; 1.
DR PANTHER; PTHR23319; UNCHARACTERIZED; 1.
DR Pfam; PF02893; GRAM; 1.
DR Pfam; PF16016; VASt; 1.
DR SMART; SM00568; GRAM; 1.
DR PROSITE; PS51778; VAST; 1.
PE 1: Evidence at protein level;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|EPD:F8WJ74,
KW ECO:0007829|MaxQB:F8WJ74};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 575..595
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 369..521
FT /note="VASt"
FT /evidence="ECO:0000259|PROSITE:PS51778"
FT REGION 1..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 256..336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 527..566
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 44..62
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 304..318
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 541..563
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 688 AA; 76583 MW; D6DEC5B5E67B6469 CRC64;
MFDTTPHSGR SSPSSSPSLR KRLQLLPPIR PPPASEPEPG TMVEKGSDSS SEKSGVSGTL
STQSLGSRNF IRNSKKMQSW YSMLCPTYKQ RNEDFRKLFS KLPEAERLIV DYSCALQREI
LLQGRLYLSE NWICFYSNIF RWETTISIQL KEVTCLKKEK TAKLIPNAIQ ICTESEKHFF
TSFGARDRCF LLIFRLWQNA LLEKTLSPRE LWHLVHQCYG SELGLTSEDE DYVCPLQLNG
LGSPKEVGDV IALSDISPSG AADHSQEPSP VGSRRGRVTP NLSRASSDAD HGAEEDKEEQ
TDGLDASSSQ TVTPVAEPLS SEPTPPDGPT SSLGPLDLLS REELLTDTSN SSSSTGEEGD
LAALLPDLSG RLLINSVFHM GAERLQQMLF SDSPFLQGFL QQRKFTDVTL SPWSSDSKCH
QRRVLTYTIP ISNQLGPKSA SVVETQTLFR RGPQAGGCVV DSEVLTQGIP YQDYFYTAHR
YCILGLARNK ARLRNRELAK AEKLSLEEGG KDTRGLLSGL RRRKRPLSWR GHRDGPQHPD
PDPCTQTSMH TSGSLSSRFS EPSVDQGPGA GIPSALVLIS IVLIVLIALN ALLFYRLWSL
ERTAHTFESW HSLALAKGKF PQTATEWAEI LALQKHFHSV EVHKWRQILR ASVELLDEMK
FSLEKLHQGI TVPDPPLDTQ PQPDDSFP
//
