ID F8WXJ8_9BACT Unreviewed; 321 AA.
AC F8WXJ8;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=3-hydroxybutyryl-CoA dehydrogenase {ECO:0008006|Google:ProtNLM};
GN ORFNames=HMPREF9456_00707 {ECO:0000313|EMBL:EGK04954.1};
OS Dysgonomonas mossii DSM 22836.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Dysgonomonadaceae;
OC Dysgonomonas.
OX NCBI_TaxID=742767 {ECO:0000313|EMBL:EGK04954.1, ECO:0000313|Proteomes:UP000006420};
RN [1] {ECO:0000313|EMBL:EGK04954.1, ECO:0000313|Proteomes:UP000006420}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 22836 {ECO:0000313|EMBL:EGK04954.1,
RC ECO:0000313|Proteomes:UP000006420};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Pudlo N., Martens E.,
RA Allen-Vercoe E., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Alvarado L., Arachchi H.M., Berlin A., Brown A.,
RA Chapman S.B., Chen Z., Dunbar C., Freedman E., Gearin G., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heiman D., Howarth C., Larson L., Lui A.,
RA MacDonald P.J.P., Mehta T., Montmayeur A., Murphy C., Neiman D.,
RA Pearson M., Priest M., Roberts A., Saif S., Shea T., Shenoy N., Sisk P.,
RA Stolte C., Sykes S., Yandava C., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Dysgonomonas mossii DSM 22836.";
RL Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Lipid metabolism; butanoate metabolism.
CC {ECO:0000256|ARBA:ARBA00005086}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGK04954.1}.
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DR EMBL; ADLW01000002; EGK04954.1; -; Genomic_DNA.
DR RefSeq; WP_006842078.1; NZ_GL892004.1.
DR AlphaFoldDB; F8WXJ8; -.
DR STRING; 742767.HMPREF9456_00707; -.
DR GeneID; 78081387; -.
DR eggNOG; COG1250; Bacteria.
DR HOGENOM; CLU_009834_2_0_10; -.
DR OrthoDB; 9771883at2; -.
DR Proteomes; UP000006420; Unassembled WGS sequence.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0044248; P:cellular catabolic process; IEA:UniProt.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR022694; 3-OHacyl-CoA_DH.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF5; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR PIRSF; PIRSF000105; HCDH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000006420}.
FT DOMAIN 25..209
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 213..308
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT SITE 166
FT /note="Important for catalytic activity"
FT /evidence="ECO:0000256|PIRSR:PIRSR000105-1"
SQ SEQUENCE 321 AA; 36373 MW; 8166B796E24C0C29 CRC64;
MAEIIEPIEE YGLSSKNKKR SLFSKIGVVG CGRDGRHIVS LTALSGIEVT FVEVSEDRIQ
LALKDIEHGL DTKIENWGLT QGEKRSTMGR IKGTLDYQDL QDCDFVIECI RYDVDGGRST
DLRKEVFRNL EQVLSPDAII ATNATTVIIS ELAADLKYKA RCISLHFPVS HTDARLLEIV
RGTFTSEEAV RKVYHFAHMI KHTAIQVHES SGLVSFRMMI TMLNEACQIW MENVASIEDI
DKEFTIIFGQ RFGIFQLADI LGIEKLVMLM EDMFDEYGDK KYKASPVLWK LFRSKQLGVS
TKRGFYIYDD AGKIIGPNDL I
//
