ID   F8X0A8_9BACT            Unreviewed;      1078 AA.
AC   F8X0A8;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   27-MAR-2024, entry version 59.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN   ORFNames=HMPREF9456_01870 {ECO:0000313|EMBL:EGK03803.1};
OS   Dysgonomonas mossii DSM 22836.
OC   Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Dysgonomonadaceae;
OC   Dysgonomonas.
OX   NCBI_TaxID=742767 {ECO:0000313|EMBL:EGK03803.1, ECO:0000313|Proteomes:UP000006420};
RN   [1] {ECO:0000313|EMBL:EGK03803.1, ECO:0000313|Proteomes:UP000006420}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 22836 {ECO:0000313|EMBL:EGK03803.1,
RC   ECO:0000313|Proteomes:UP000006420};
RG   The Broad Institute Genome Sequencing Platform;
RA   Earl A., Ward D., Feldgarden M., Gevers D., Pudlo N., Martens E.,
RA   Allen-Vercoe E., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA   Abouelleil A., Alvarado L., Arachchi H.M., Berlin A., Brown A.,
RA   Chapman S.B., Chen Z., Dunbar C., Freedman E., Gearin G., Gellesch M.,
RA   Goldberg J., Griggs A., Gujja S., Heiman D., Howarth C., Larson L., Lui A.,
RA   MacDonald P.J.P., Mehta T., Montmayeur A., Murphy C., Neiman D.,
RA   Pearson M., Priest M., Roberts A., Saif S., Shea T., Shenoy N., Sisk P.,
RA   Stolte C., Sykes S., Yandava C., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Dysgonomonas mossii DSM 22836.";
RL   Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EGK03803.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; ADLW01000006; EGK03803.1; -; Genomic_DNA.
DR   RefSeq; WP_006843241.1; NZ_GL892006.1.
DR   AlphaFoldDB; F8X0A8; -.
DR   STRING; 742767.HMPREF9456_01870; -.
DR   GeneID; 78082514; -.
DR   eggNOG; COG1074; Bacteria.
DR   HOGENOM; CLU_010638_0_0_10; -.
DR   OrthoDB; 9810135at2; -.
DR   Proteomes; UP000006420; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070:SF64; ATP-DEPENDENT DNA HELICASE REP; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF00580; UvrD-helicase; 2.
DR   Pfam; PF13361; UvrD_C; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR   PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000006420}.
FT   DOMAIN          1..472
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51198"
FT   DOMAIN          503..760
FT                   /note="UvrD-like helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51217"
FT   BINDING         18..25
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ   SEQUENCE   1078 AA;  125389 MW;  6A3795F86660E620 CRC64;
     MSNHASFDDE INLYVYKASA GSGKTHRLTE KYLNLLFSSP FAYRHILAVT FTNKATDEMK
     SRIIEELANI ATGQESDHIS FLSKEYKYNE EQVRKEGRDI LVRILHDYSS FSVSTIDKFF
     QQTMRAFTRE IGLGGGYNVE LDTNKVLGEA IDSMLYDLER TDNKLLLDWL IRFSEEKVEN
     GETWNIRNDI QSLSSEIFKE SYKAYSNQVQ TDINNKQLMT DYKDMLFTII RDFEKASQQI
     GEKALNIMSR FGLKGEDFKG GTRSPFLNFL KWANGTIAEP TDTFRTLADN LSGWYTKTTG
     SATRDKIENV YPELNICVCE IINHYDNSLI YQTAYEINRY FFTLGILGDV DKKIREYSTE
     NNIMLISDTT ELLNRIIEGN ESPFIYEKVG QRINNYMIDE FQDTSGMQWQ NFLPLVKDSL
     ASGNKNYIVG DVKQSIYRWR NSDWKLLDEQ LDIDFRTEGI EHDTLDTNWR SSCNVINFNN
     AVFSIGSALL QDTFNKSLQD LDNAKLKPFL TRITKAYDEL YQEIPESHKN NEGRVRVEFI
     DTDEYIWQNY VLDQLPIEIE QLQERGYSLK DIAILVRTKK EGADVANCLL EYKKLHPDSK
     YRYDIISDEA LFVSNSKSIK LIIALLKHLH NPLDKSLKAL AVFEYFKYSK QMNAEEALLK
     YFSAKDDLPQ QIEDRLSHIR ELPLYEMTEE IFNLFREAME NDEQVYIQSF LDMVLDFTVR
     NSSDLDAFLR WWDETGTNKT IFTPDGQDAI RIMTIHKSKG LGFNVVLIPF CNWEIDHKLT
     TILWCHPQTE PFNRLHLVPV KYSQKLKNTI FAYEYFDERL HAFIDNINVL YVAFTRAKNE
     LIAYAPKPKK EEVNNISSLL WSTINSGSLG DGKQAYTDLS QHIDEETATF EIGENYVPIK
     KVTHRSVEEI SVDSLSSIPY DERVKLLLKN KYFFTDTGQR DYGTLMHEIV SKVKTIDDVQ
     KAVEEYHIVG EVTTSDKNKI TGLLEEYLSN PLVAPWYSGE YKVLNEIQIL QPKGKFVRPD
     RVMIKGKEVI VIDYKFGEKE DKKYIRQVKY YADQIRKMGY TDIKGYICYI TLGKIVEI
//