ID F9D000_PREDD Unreviewed; 433 AA.
AC F9D000;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=NCS2 family nucleobase:cation symporter-2 {ECO:0000313|EMBL:EGQ17572.1};
DE SubName: Full=Permease {ECO:0000313|EMBL:AGB27944.1};
GN OrderedLocusNames=Prede_0585 {ECO:0000313|EMBL:AGB27944.1};
GN ORFNames=HMPREF9136_0177 {ECO:0000313|EMBL:EGQ17572.1};
OS Prevotella dentalis (strain ATCC 49559 / DSM 3688 / JCM 13448 / NCTC 12043
OS / ES 2772) (Mitsuokella dentalis).
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Prevotellaceae;
OC Prevotella.
OX NCBI_TaxID=908937 {ECO:0000313|EMBL:EGQ17572.1, ECO:0000313|Proteomes:UP000007820};
RN [1] {ECO:0000313|EMBL:EGQ17572.1, ECO:0000313|Proteomes:UP000007820}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 3688 {ECO:0000313|EMBL:EGQ17572.1,
RC ECO:0000313|Proteomes:UP000007820};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AGB27944.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 3688 {ECO:0000313|EMBL:AGB27944.1};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Peters L., Mikhailova N., Chertkov O.,
RA Kyrpides N., Mavromatis K., Ivanova N., Brettin T., Detter J.C., Han C.,
RA Larimer F., Land M., Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P.,
RA Woyke T., Wu D., Gronow S., Wellnitz S., Brambilla E., Klenk H.-P.,
RA Eisen J.A.;
RT "Complete sequence of chromosome 1 of Prevotella dentalis DSM 3688.";
RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000010862}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 49559 / DSM 3688 / JCM 13448 / NCTC 12043 / ES 2772
RC {ECO:0000313|Proteomes:UP000010862};
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Peters L., Mikhailova N., Chertkov O.,
RA Kyrpides N., Mavromatis K., Ivanova N., Brettin T., Detter J.C., Han C.,
RA Larimer F., Land M., Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P.,
RA Woyke T., Wu D., Gronow S., Wellnitz S., Brambilla E., Klenk H.-P.,
RA Eisen J.A.;
RT "Complete sequence of chromosome 1 of Prevotella dentalis DSM 3688.";
RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|PIRNR:PIRNR005353};
CC Multi-pass membrane protein {ECO:0000256|PIRNR:PIRNR005353}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC 2.A.40) family. Azg-like subfamily. {ECO:0000256|ARBA:ARBA00005697,
CC ECO:0000256|PIRNR:PIRNR005353}.
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DR EMBL; CP003368; AGB27944.1; -; Genomic_DNA.
DR EMBL; AFPW01000002; EGQ17572.1; -; Genomic_DNA.
DR RefSeq; WP_005843480.1; NZ_GL982488.1.
DR AlphaFoldDB; F9D000; -.
DR STRING; 908937.Prede_0585; -.
DR KEGG; pdt:Prede_0585; -.
DR PATRIC; fig|908937.9.peg.610; -.
DR eggNOG; COG2252; Bacteria.
DR HOGENOM; CLU_024508_0_1_10; -.
DR OrthoDB; 9808458at2; -.
DR Proteomes; UP000007820; Unassembled WGS sequence.
DR Proteomes; UP000010862; Chromosome 1.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015205; F:nucleobase transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1904823; P:purine nucleobase transmembrane transport; IEA:UniProt.
DR InterPro; IPR045018; Azg-like.
DR InterPro; IPR026033; Azg-like_bact_archaea.
DR InterPro; IPR006043; NCS2.
DR PANTHER; PTHR43337; XANTHINE/URACIL PERMEASE C887.17-RELATED; 1.
DR PANTHER; PTHR43337:SF1; XANTHINE_URACIL PERMEASE C887.17-RELATED; 1.
DR Pfam; PF00860; Xan_ur_permease; 1.
DR PIRSF; PIRSF005353; PbuG; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|PIRNR:PIRNR005353};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR005353};
KW Reference proteome {ECO:0000313|Proteomes:UP000010862};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|PIRNR:PIRNR005353};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|PIRNR:PIRNR005353};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR005353}.
FT TRANSMEM 21..44
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 50..69
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 103..121
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 133..150
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 170..188
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 195..214
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 245..266
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 322..342
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 376..403
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 415..432
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 433 AA; 46272 MW; EC6801F859A9BF60 CRC64;
MKFFEKALGF NPASNRLRTE LVAGATTFLT MSYVLAVNPT ILASTGMDKG ALFTATALAA
AISTLLLAFM AKLPFAQAPS MGLNAFFAYT LCQAMHYTWQ QSLAIMFIEG LIFLLITFFN
IREMILDSIP ENLRYAISGG IGMFIAFIGL KNAEIIVPKE GTFVGLGEFT PTSILGIIAI
MLSGILMARR VKGALFYAII ATAVIGIPMG VTRIPEHWFP VSVPHSLAPI FCQFDFASLL
NTNTLLVVIS LLIVNIFDTV GTLVGLAQKT GVVKADGTIP HVKEAMMSDA IGTTCGAMLG
SSTITTYVES ASGIAEGGRT GVTSFVVGLL FIFSLLLSPV FLLIPSPATS GALVLVGVLM
LDSMKKINLS NVAEAFPAFI TMITMVLCYS IADGICLGIL SYVILKLCIG KWSELNWTLV
VLSVLFVLNF VFA
//
