ID F9F650_FUSOF Unreviewed; 1155 AA.
AC F9F650;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 24-JAN-2024, entry version 43.
DE RecName: Full=26S proteasome regulatory subunit RPN2 {ECO:0000256|PIRNR:PIRNR015947};
GN ORFNames=FOXB_01875 {ECO:0000313|EMBL:EGU87590.1};
OS Fusarium oxysporum (strain Fo5176) (Fusarium vascular wilt).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium oxysporum species complex.
OX NCBI_TaxID=660025 {ECO:0000313|EMBL:EGU87590.1};
RN [1] {ECO:0000313|EMBL:EGU87590.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Fo5176 {ECO:0000313|EMBL:EGU87590.1};
RX PubMed=21942452; DOI=10.1094/mpmi-08-11-0212;
RA Thatcher L.F., Gardiner D.M., Kazan K., Manners J.;
RT "A highly conserved effector in Fusarium oxysporum is required for full
RT virulence on Arabidopsis.";
RL Mol. Plant Microbe Interact. 25:180-190(2012).
CC -!- FUNCTION: Acts as a regulatory subunit of the 26S proteasome which is
CC involved in the ATP-dependent degradation of ubiquitinated proteins.
CC {ECO:0000256|PIRNR:PIRNR015947}.
CC -!- SIMILARITY: Belongs to the proteasome subunit S1 family.
CC {ECO:0000256|ARBA:ARBA00006308, ECO:0000256|PIRNR:PIRNR015947}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGU87590.1}.
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DR EMBL; AFQF01000632; EGU87590.1; -; Genomic_DNA.
DR AlphaFoldDB; F9F650; -.
DR STRING; 660025.F9F650; -.
DR PaxDb; 5507-FOXG_15464P0; -.
DR GO; GO:0008540; C:proteasome regulatory particle, base subcomplex; IEA:UniProtKB-UniRule.
DR GO; GO:0030234; F:enzyme regulator activity; IEA:UniProtKB-UniRule.
DR GO; GO:0042176; P:regulation of protein catabolic process; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR016642; 26S_Psome_Rpn2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR002015; Proteasome/cyclosome_rpt.
DR InterPro; IPR048570; PSMD1_RPN2_N.
DR InterPro; IPR040623; RPN2_C.
DR PANTHER; PTHR10943; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10943:SF2; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1; 1.
DR Pfam; PF13646; HEAT_2; 1.
DR Pfam; PF01851; PC_rep; 2.
DR Pfam; PF18004; RPN2_C; 1.
DR Pfam; PF21505; RPN2_N; 2.
DR PIRSF; PIRSF015947; 26S_Psome_Rpn2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Proteasome {ECO:0000256|ARBA:ARBA00022942, ECO:0000256|PIRNR:PIRNR015947};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 6..133
FT /note="26S proteasome non-ATPase regulatory subunit 1/RPN2
FT N-terminal"
FT /evidence="ECO:0000259|Pfam:PF21505"
FT DOMAIN 193..423
FT /note="26S proteasome non-ATPase regulatory subunit 1/RPN2
FT N-terminal"
FT /evidence="ECO:0000259|Pfam:PF21505"
FT DOMAIN 867..1036
FT /note="26S proteasome regulatory subunit RPN2 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18004"
FT REGION 360..393
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 919..987
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1043..1066
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1093..1155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 375..389
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 921..987
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1155 AA; 126332 MW; 3680D99C8576980C CRC64;
MPGIVSATGV LAFLTDEEPE LKVFALQTLN DDIDTVWTEV AAVLTQIEAL YEDESFPERQ
LAALVLAKVY YHLQAYNDSM VFALAAGDLF KLDSPGEFEE TIISKCVDQY IAVNAAKKAV
PQASKNTDLP ELATTFASGA EGAVMSPTTP FSQTTLPPKS LLSRDSIDNT MLEATFQPAF
KQGRSGSIAE LPDQATGSLQ RVVERLFESC LEQGRYRQVV GIAVEAKKLD VLRSVIKRAS
DDEKKAKSNP LENSPGPAED LMEYTLGICM DIVQERAFRT EILRLILDLL NEIPNPDYFA
IAKCVVYLNS DEEASRMLRN LVEKGDRSSI ANAYQIAFDL YDNGTQEFLG KVLASLPASK
PVKKESDENG EQSHESESLL QNKQEAPENE LPEQVSKAYS NIREILDGSK TIRLNLEFLY
RNNRTDLSIL NKVRDSLEGR NSIFHTAVTF CNAFMNQGTT NDKFFRDNLE WLGKAVNWSK
FTATAALGVI HRGNLSQSRK LLEPYLPRQG GLSSGSIFSQ GGALYAYGLI HANHGADALD
YLKEQFSQAE EEVVQHGGAL GLGIAGMATG DWEIFEKLRE ILFQDSALNG EAVGLAMGLI
MLGTGNVKAL EDMITYAHET THEKIVRGLA IGMALIMFGR QEGADVLIEG LLNDPDPTLR
YGGIMTVALA YCGTGSNKAI RKLLHIAVSD VNDDVRRIAV MSLGFILFRK PGSVPRMVEL
LSESYNPHVR YGSAMALGIS CAGTGLDEAI DLLEPMMKDP TDFVRQGALI SLAMILVQQN
EVMNPKVSSI RKTLKKVVGD RHEDAMTKFG AALALGIIDA GGRNCTIGLQ TQTGNLNMAG
IVGMAVFTQY WYWFPFTHFL SLSFSPTSII GLDHDLEMPN FKFHCATRPS LFDYPPEQEV
KTEEGPALIA TAILSTTAQA KRRAQKKERA QRRESMEIDT APSKSGGDKM DVDEDKKADE
TKDKKEEQEK EPAASADTKK KPEKEKVGYE IENMTRVLPG QLKYISFPAG RYKPVKKPTG
GPLLLHDSQP DEEKSLLEEK LKKVTTERAP VAGQQTGRGG RGGAQRAVLD SLAESRGGAN
SAMLGQLLRN QGRSPFGLLD AEPQTPGGNA SGAAAAAGVL TAVDEDSDDD EEAPVPKEFE
YFTDAGEDDD DDDDE
//
