ID   F9FZ60_FUSOF            Unreviewed;       958 AA.
AC   F9FZ60;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   27-MAR-2024, entry version 45.
DE   RecName: Full=Exosome complex exonuclease dis3 {ECO:0008006|Google:ProtNLM};
GN   ORFNames=FOXB_11697 {ECO:0000313|EMBL:EGU77833.1};
OS   Fusarium oxysporum (strain Fo5176) (Fusarium vascular wilt).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC   Fusarium oxysporum species complex.
OX   NCBI_TaxID=660025 {ECO:0000313|EMBL:EGU77833.1};
RN   [1] {ECO:0000313|EMBL:EGU77833.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Fo5176 {ECO:0000313|EMBL:EGU77833.1};
RX   PubMed=21942452; DOI=10.1094/mpmi-08-11-0212;
RA   Thatcher L.F., Gardiner D.M., Kazan K., Manners J.;
RT   "A highly conserved effector in Fusarium oxysporum is required for full
RT   virulence on Arabidopsis.";
RL   Mol. Plant Microbe Interact. 25:180-190(2012).
CC   -!- SIMILARITY: Belongs to the RNR ribonuclease family.
CC       {ECO:0000256|ARBA:ARBA00005785, ECO:0000256|RuleBase:RU003901}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EGU77833.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AFQF01002925; EGU77833.1; -; Genomic_DNA.
DR   AlphaFoldDB; F9FZ60; -.
DR   STRING; 660025.F9FZ60; -.
DR   PaxDb; 5507-FOXG_00205P0; -.
DR   GO; GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0004540; F:RNA nuclease activity; IEA:InterPro.
DR   CDD; cd09862; PIN_Rrp44-like; 1.
DR   Gene3D; 2.40.50.690; -; 1.
DR   Gene3D; 2.40.50.700; -; 1.
DR   Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR   InterPro; IPR041505; Dis3_CSD2.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR029060; PIN-like_dom_sf.
DR   InterPro; IPR002716; PIN_dom.
DR   InterPro; IPR001900; RNase_II/R.
DR   InterPro; IPR022966; RNase_II/R_CS.
DR   InterPro; IPR033771; Rrp44_CSD1.
DR   InterPro; IPR033770; RRP44_S1.
DR   PANTHER; PTHR23355:SF35; EXOSOME COMPLEX EXONUCLEASE RRP44; 1.
DR   PANTHER; PTHR23355; RIBONUCLEASE; 1.
DR   Pfam; PF17849; OB_Dis3; 1.
DR   Pfam; PF13638; PIN_4; 1.
DR   Pfam; PF00773; RNB; 1.
DR   Pfam; PF17216; Rrp44_CSD1; 1.
DR   Pfam; PF17215; Rrp44_S1; 1.
DR   SMART; SM00670; PINc; 1.
DR   SMART; SM00955; RNB; 1.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 4.
DR   SUPFAM; SSF88723; PIN domain-like; 1.
DR   PROSITE; PS01175; RIBONUCLEASE_II; 1.
PE   3: Inferred from homology;
KW   Exosome {ECO:0000256|ARBA:ARBA00022835};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT   DOMAIN          85..204
FT                   /note="PIN"
FT                   /evidence="ECO:0000259|SMART:SM00670"
FT   DOMAIN          514..822
FT                   /note="Ribonuclease II/R"
FT                   /evidence="ECO:0000259|SMART:SM00955"
SQ   SEQUENCE   958 AA;  108543 MW;  6775625BA0CECC11 CRC64;
     MASLKRSTET DSLASNISSK VYVRSTRSGK VQKIVREVYL RTDIPCSSKL CKACLQDAPR
     NAAQQAQPFV LSDKPAGTET FPQGHYLVPD TNALLNAMDL FEQSSAFYDV IILQTVLEEL
     RNRSLPLYNR LVGLTKSEDK RFYVFFNDFR LETFVHRQAN ETVNDRNDRA VRLAVKWYGE
     HLARTKAKKL PAVVMLSDDR ENLRKAKEEG LHASSLRDYV SGLEDGERLL DMVAEAQNQE
     SFKKQGQMLY PEYFTLSRMM TGVKAGLMHQ GIFNVSPYNY LEGSIKVPAF PKPLLVLGRE
     NINRAVDGDV VVVEVLPQDQ WKEPSTKIIE EDAITKNENA DVEESQDLVS EKERKALQEQ
     VRKTQKSASE SKPQPTAKVV GVIKRNWRQY VGHIDPSSAS KGSSQGRKQD SVFLIPMDKK
     IPKIRLRTRQ VADLLGKRLL VTIDAWERDS RHPVGHFVRS LGELETKSAE TEALLLEWDV
     QYRPFPKTVL DCLPREGHDW RVPTSMEDPG WRQREDLRGL LICSIDPVGC QDIDDALHAK
     QLPNGNYEVG VHIADVSNFV KPANAMDTEA SIRGTTVYLV DKRIDMLPPL LGTDLCSLKP
     YVERFAFSVL WELNDNADIV NVRFTKSVIK SREAFSYEQA QLRIDDESQQ DDLTKGMRML
     LMLSKKLKKK RMDAGALSLS SPEVKVQTES ETSDPIDVKT KQLLDTNSLV EEFMLFANVS
     VAAKIYEAFP QTAILRRHAA PQRQTLTNYQ TNSAPSVAWS CGPTPARPLP ILWIKYFCSG
     TQAYPEFRHY GLASEIYTHF TSPIRRYADL LAHRQLAAAI DYEAIHPNVR SRGRLEAVCK
     NINVRHRNAQ MAGRASIAYY VGQALKGKVA EEDAFVMKIF SNGFVVLVPR FGTEGLIRLR
     DLAEPEPEAE YDAETYTLTT KGSREIKVEL FQKVRVRVRD EKDEMTGKRG VKMELIEA
//