ID F9N5P6_9FIRM Unreviewed; 306 AA.
AC F9N5P6;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 24-JAN-2024, entry version 43.
DE SubName: Full=Glycyl-radical enzyme activating protein {ECO:0000313|EMBL:EGS34798.1};
DE EC=1.97.1.- {ECO:0000313|EMBL:EGS34798.1};
GN ORFNames=HMPREF9200_0631 {ECO:0000313|EMBL:EGS34798.1};
OS Veillonella sp. oral taxon 780 str. F0422.
OC Bacteria; Bacillota; Negativicutes; Veillonellales; Veillonellaceae;
OC Veillonella.
OX NCBI_TaxID=944564 {ECO:0000313|EMBL:EGS34798.1, ECO:0000313|Proteomes:UP000010295};
RN [1] {ECO:0000313|EMBL:EGS34798.1, ECO:0000313|Proteomes:UP000010295}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F0422 {ECO:0000313|EMBL:EGS34798.1,
RC ECO:0000313|Proteomes:UP000010295};
RA Harkins D.M., Madupu R., Durkin A.S., Torralba M., Methe B., Sutton G.G.,
RA Nelson K.E.;
RL Submitted (JUN-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- SIMILARITY: Belongs to the organic radical-activating enzymes family.
CC {ECO:0000256|ARBA:ARBA00009777}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGS34798.1}.
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DR EMBL; AFUJ01000040; EGS34798.1; -; Genomic_DNA.
DR RefSeq; WP_009353686.1; NZ_AFUJ01000040.1.
DR AlphaFoldDB; F9N5P6; -.
DR eggNOG; COG1180; Bacteria.
DR OrthoDB; 9782387at2; -.
DR Proteomes; UP000010295; Unassembled WGS sequence.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR CDD; cd01335; Radical_SAM; 1.
DR Gene3D; 3.30.70.20; -; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR040074; BssD/PflA/YjjW.
DR InterPro; IPR034457; Organic_radical-activating.
DR InterPro; IPR012839; Organic_radical_activase.
DR InterPro; IPR001989; Radical_activat_CS.
DR InterPro; IPR007197; rSAM.
DR NCBIfam; TIGR02494; PFLE_PFLC; 1.
DR PANTHER; PTHR30352:SF4; PYRUVATE FORMATE-LYASE 2-ACTIVATING ENZYME; 1.
DR PANTHER; PTHR30352; PYRUVATE FORMATE-LYASE-ACTIVATING ENZYME; 1.
DR Pfam; PF13353; Fer4_12; 1.
DR Pfam; PF13187; Fer4_9; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR PIRSF; PIRSF000371; PFL_act_enz; 1.
DR SFLD; SFLDG01118; activating_enzymes__group_2; 1.
DR SFLD; SFLDS00029; Radical_SAM; 1.
DR SUPFAM; SSF54862; 4Fe-4S ferredoxins; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS00198; 4FE4S_FER_1; 2.
DR PROSITE; PS51379; 4FE4S_FER_2; 2.
DR PROSITE; PS01087; RADICAL_ACTIVATING; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 3: Inferred from homology;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:EGS34798.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000010295};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT DOMAIN 21..301
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
FT DOMAIN 52..76
FT /note="4Fe-4S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51379"
FT DOMAIN 80..109
FT /note="4Fe-4S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51379"
SQ SEQUENCE 306 AA; 34521 MW; C911042FA943A271 CRC64;
MESVDYSVQG TVFDIQRFSI HDGPGIRTIV FLKGCPLRCK WCSNPESQQY YPEVVYRKQL
CIGCKACQAV CPKQAIADSN PYWIDRTLCD NCSECTMVCP TSALSMKGKL MSVEQVVREL
KKDATQYFRS NGGITLSGGE ALTQPKFAKE IFKACKAQGW HTAIETEGYY DTKIVEEIMP
YIDLVLLDIK SVNPEQHKKF TGVDNARIKE SAKVIQSIAN TTVRVPTIPG FNASEEDIRG
IAEFVKENMP NVHDIHLLPY HNYGQGKYEL LGREYELENT PKIPEEEMET YKKIVESYGL
NCIIGG
//
