ID F9U9E1_9GAMM Unreviewed; 1848 AA.
AC F9U9E1;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=6-deoxyerythronolide-B synthase {ECO:0000313|EMBL:EGV19399.1};
DE EC=2.3.1.94 {ECO:0000313|EMBL:EGV19399.1};
GN ORFNames=ThimaDRAFT_1543 {ECO:0000313|EMBL:EGV19399.1};
OS Thiocapsa marina 5811.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Chromatiales; Chromatiaceae;
OC Thiocapsa.
OX NCBI_TaxID=768671 {ECO:0000313|EMBL:EGV19399.1, ECO:0000313|Proteomes:UP000005459};
RN [1] {ECO:0000313|EMBL:EGV19399.1, ECO:0000313|Proteomes:UP000005459}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=5811 {ECO:0000313|EMBL:EGV19399.1,
RC ECO:0000313|Proteomes:UP000005459};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Han J., Cheng J.-F., Goodwin L., Pitluck S., Peters L.,
RA Land M.L., Hauser L., Vogl K., Liu Z., Imhoff J., Thiel V., Frigaard N.-U.,
RA Bryant D., Woyke T.J.;
RT "The draft genome of Thiocapsa marina 5811.";
RL Submitted (JUN-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005194}.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP
CC synthases family. {ECO:0000256|ARBA:ARBA00008467}.
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DR EMBL; AFWV01000004; EGV19399.1; -; Genomic_DNA.
DR STRING; 768671.ThimaDRAFT_1543; -.
DR PATRIC; fig|768671.3.peg.1642; -.
DR eggNOG; COG3321; Bacteria.
DR OrthoDB; 9778690at2; -.
DR UniPathway; UPA00094; -.
DR Proteomes; UP000005459; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0047879; F:erythronolide synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 2.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR Pfam; PF00698; Acyl_transf_1; 2.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF00550; PP-binding; 2.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000313|EMBL:EGV19399.1};
KW Fatty acid biosynthesis {ECO:0000256|ARBA:ARBA00023160};
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00023160};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023160};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000005459};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EGV19399.1}.
FT DOMAIN 381..459
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 483..905
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1747..1826
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 338..380
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 458..479
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1848 AA; 197207 MW; 66CA4B3B76F67F99 CRC64;
MRLNLGNRIY YRDAGGLEEP GRVAVLFPGF GHRDTGLARQ LCGLSPAVDA WYGSVAGPRP
FGLASGDSGS ELAGMLDDVL MADLAMWVLL RDLGLSCDLL VGHSFGEHAA LVASGMVPSL
ADLSPLFASV ASLDAEGDPL GMLAITEAAV DLIAPEMQRD PPSVFMALDN CRQQKVFWGQ
PEVLGRVEAQ VKAQGLLAYR LAGLACPVHT PAFPVGGEQL RRDYAALALS APRIPVWSCS
RLRPLPEERT AATEVLAAQW HEPVRFRESI LALFDAGFRT FVEVGPGERL SGFVRETLRG
KGVSAVPTHR EGHPPLQTIH VALAQLYLLG QAIAPDRLSP RPSVSEERFD GRGITSSGPP
ETRGESGPPP AVQQPASTDR QRFRDLVEVI QGEVAGLLDL ADPESLDSET GFFDLGLGSL
GCVELSERLG RVLGRSLPQT LAFDYPDITR LARALASAPG TSPECAGSDA GRATAASESA
SENEPIAIVG IGCRFPGGVD SPDAFWQLLR EGRDAISEVP PERWDPGVYE GWIDADQREA
ARFGGFLADA LGFDADFFGI SPREAKTLDP QQRMLLEVSW ESLEDACIDP KGLGGSRTGV
FVGISSADYV QRLSPTQRLE VGGYLATGNA PSTAAGRIAF ALGLNGPAMA VDTACSSSLV
AVHLACASLR RGESDLALAG GVNLMLNPET TVFLANAHAL SRSGRCRTFD AGADGYVRAE
GCGVVVLKRL SDALAAGDAV VAVVLGSAVN HDGRTSGLTV PSGPAQNALI RDCLHSAGVE
PSEVGYLEAH GTGTPLGDPI ELQALGEVFR STRAVPLRLG SVKSNIGHLE AAAGIAGLIK
AALQLRRRRL VPSLHFRTPN PRSNWASLPF EVNRDDRDWD SVGRRIAGVS SFGISGTNAH
VILAEAQSTR SAIEQNAESD GADTGRAHLL VLSARTPEAL RTAALRMVDR LEESPVDRSM
DPGAVEPGAF TTLVGCPAST LVDCASLVHP TPLVHPTPLV QPTAPIGDVA GFIGDAVEPL
SALCRTSWLG RHHWRYRIGV VARSRLEARD RLRERMASAA VDRAGAEARA PRVAFLFTGQ
GSHEPGMGRE LYATEPVFRR AFDRCCEGLA PDLEAPLAEV VLDPRDRRLE QTAWAQPGLF
ALEYALVETW RSRGIVPDVV MGHSLGEYVA ACVAGVMSLE DALRLVAVRA RLMQSLPAGG
GMLSVAASPE GLESVVSLAS LGLDLAAVNG PASLVVAGPV GALDRAERRL MEAGIGCRRL
PVSHAFHSRL VEPILAEFGR YVAACRLSEP RIEMVSNLTG ERVRHEVTDP AYWVDHLRRT
VRFEAGMRTL STLGCDAYVE IGPKPVLTAL GRESADDARG VLWLASMQPP VDPSLTLLNA
LGQLYERGAD PEWTGLEPAA AKRPRARLPT TPFERRSFWI EIAEGRHDAV APSDAPPRLP
GLLLNLPGNT GALRFEARTG VGLTPELDGY PALAERALPP GLLLYAALRA ARRAAPGIEM
WLEALRLVDV QRLADPCVIL HTLVKTPNAD PGVVEIYGRA EGVEDAPWSL LIQARLRAVS
GSPQPEPRPM SGRTRDADES LLARLRSAHS AIEKAAFYRA GEQLGFRYGP DLQVLREIRL
GMHAASAVLD LQTGGGVDPS PLPDLPLAAI EGGLQLLGGL DAGATPPRVR QLRAIDRIDV
AAPLPREVLV LVWRAEDHAS ATIRLLDARS FLLCAELSGI QSDAMEITRV STAEGEIRDR
LERVPREEWP PLIVGFVNRI AGLIIDGSPD YRIDPSRPLT ELGLDSLMAL RIAIELKADL
GVEIPVSQIV SGATIETLAA VSVEQVMDGD LTTEVSQRLD GFFQEGEL
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