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Database: UniProt
Entry: F9UMJ0_LACPL
LinkDB: F9UMJ0_LACPL
Original site: F9UMJ0_LACPL 
ID   F9UMJ0_LACPL            Unreviewed;       560 AA.
AC   F9UMJ0;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   28-MAR-2018, entry version 39.
DE   SubName: Full=Acetolactate synthase {ECO:0000313|EMBL:CCC78429.1};
DE            EC=2.2.1.6 {ECO:0000313|EMBL:CCC78429.1};
GN   Name=als {ECO:0000313|EMBL:CCC78429.1};
GN   OrderedLocusNames=lp_1005 {ECO:0000313|EMBL:CCC78429.1};
OS   Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=220668 {ECO:0000313|EMBL:CCC78429.1, ECO:0000313|Proteomes:UP000000432};
RN   [1] {ECO:0000313|EMBL:CCC78429.1, ECO:0000313|Proteomes:UP000000432}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-793 / NCIMB 8826 / WCFS1
RC   {ECO:0000313|Proteomes:UP000000432};
RX   PubMed=12566566; DOI=10.1073/pnas.0337704100;
RA   Kleerebezem M., Boekhorst J., van Kranenburg R., Molenaar D.,
RA   Kuipers O.P., Leer R., Tarchini R., Peters S.A., Sandbrink H.M.,
RA   Fiers M.W.E.J., Stiekema W., Klein Lankhorst R.M., Bron P.A.,
RA   Hoffer S.M., Nierop Groot M.N., Kerkhoven R., De Vries M., Ursing B.,
RA   De Vos W.M., Siezen R.J.;
RT   "Complete genome sequence of Lactobacillus plantarum WCFS1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:1990-1995(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=WCFS1;
RA   Siezen R.J., Francke C., Renckens B., Boekhorst J., Wels M.,
RA   Kleerebezem M., van Hijum S.A.F.T.;
RT   "Complete resequencing and reannotation of the Lactobacillus plantarum
RT   WCFS1 genome.";
RL   Submitted (JUN-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:CCC78429.1, ECO:0000313|Proteomes:UP000000432}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-793 / NCIMB 8826 / WCFS1
RC   {ECO:0000313|Proteomes:UP000000432};
RX   PubMed=22156394; DOI=10.1128/JB.06275-11;
RA   Siezen R.J., Francke C., Renckens B., Boekhorst J., Wels M.,
RA   Kleerebezem M., van Hijum S.A.F.T.;
RT   "Complete resequencing and reannotation of the Lactobacillus plantarum
RT   WCFS1 genome.";
RL   J. Bacteriol. 194:195-196(2012).
CC   -!- SIMILARITY: Belongs to the TPP enzyme family.
CC       {ECO:0000256|RuleBase:RU362132}.
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DR   EMBL; AL935263; CCC78429.1; -; Genomic_DNA.
DR   RefSeq; WP_003644083.1; NC_004567.2.
DR   RefSeq; YP_004888943.1; NC_004567.2.
DR   ProteinModelPortal; F9UMJ0; -.
DR   STRING; 220668.lp_1005; -.
DR   EnsemblBacteria; CCC78429; CCC78429; lp_1005.
DR   GeneID; 1063603; -.
DR   KEGG; lpl:lp_1005; -.
DR   PATRIC; fig|220668.9.peg.852; -.
DR   eggNOG; ENOG4105C7K; Bacteria.
DR   eggNOG; COG0028; LUCA.
DR   KO; K01652; -.
DR   OMA; IRWKQAV; -.
DR   BioCyc; LPLA220668:G1GW0-865-MONOMER; -.
DR   Proteomes; UP000000432; Chromosome.
DR   GO; GO:0003984; F:acetolactate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   GO; GO:0034077; P:butanediol metabolic process; IEA:InterPro.
DR   InterPro; IPR012782; Acetolactate_synth_catblc.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR   InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR   InterPro; IPR000399; TPP-bd_CS.
DR   InterPro; IPR011766; TPP_enzyme-bd_C.
DR   Pfam; PF02775; TPP_enzyme_C; 1.
DR   Pfam; PF00205; TPP_enzyme_M; 1.
DR   Pfam; PF02776; TPP_enzyme_N; 1.
DR   SUPFAM; SSF52467; SSF52467; 1.
DR   SUPFAM; SSF52518; SSF52518; 2.
DR   TIGRFAMs; TIGR02418; acolac_catab; 1.
DR   PROSITE; PS00187; TPP_ENZYMES; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000432};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000432};
KW   Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132};
KW   Transferase {ECO:0000313|EMBL:CCC78429.1}.
FT   DOMAIN        8    175       TPP_enzyme_N. {ECO:0000259|Pfam:PF02776}.
FT   DOMAIN      199    330       TPP_enzyme_M. {ECO:0000259|Pfam:PF00205}.
FT   DOMAIN      394    540       TPP_enzyme_C. {ECO:0000259|Pfam:PF02775}.
SQ   SEQUENCE   560 AA;  61232 MW;  64E52A8B78073879 CRC64;
     MPDKKYYGAD AIVDSLVNHD VKYVFGIPGA KIDRVFERLE HPVNPKSPRL IVTRHEQNAA
     FIAAGIGRIT GKPGVVMTTS GPGASNLATG LVTATAEGDP VLAISGQVQR ADLLRLTHQS
     MNNAALFKPI TKYSAEVQEP ENISEVLANA YQEATAAKQG ASFVSVPQDV TDSIVRTPVI
     TPIQAPKLGP ASPVEATLLA QKIKAAKLPV LLVGMRASSP EVTKAIRNLV AAANLPVVET
     FQAAGVISRD LEANHFFGRV GLFRNQPGDM LLKKSDLVIA VGYDPIEYEP RNWNAEGKSR
     IVVIDAMRAE IDHNFQPETE LIGDIAQTLD FLLPYMKGYD ISDSARAYLG ELQERLQTRD
     FVPNIDKQSK LNHPLSVIAA LQQRVSDDMT VTVDVGSHYI WMARHFRSYE PRHLLFSNGM
     QTLGVALPWA IAAALVRPDT QIVSVSGDGG FLFSAQELET AVRLKQNIVH LIWNDGTYDM
     VKFQEEMKYG EDAAVHFGPV DFVKYAESFG ATGLRVNQPA DLEKVLDQAF ATDGPVVVDI
     PIDYSDNKAL GKTMLPDQFY
//
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