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Database: UniProt
Entry: F9VEK9_LACGL
LinkDB: F9VEK9_LACGL
Original site: F9VEK9_LACGL 
ID   F9VEK9_LACGL            Unreviewed;       374 AA.
AC   F9VEK9;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   24-JAN-2024, entry version 60.
DE   RecName: Full=Heme chaperone HemW {ECO:0000256|RuleBase:RU364116};
GN   OrderedLocusNames=LCGL_1300 {ECO:0000313|EMBL:BAK60760.1};
OS   Lactococcus garvieae (strain Lg2) (Enterococcus seriolicida).
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus.
OX   NCBI_TaxID=420890 {ECO:0000313|EMBL:BAK60760.1, ECO:0000313|Proteomes:UP000008520};
RN   [1] {ECO:0000313|EMBL:BAK60760.1, ECO:0000313|Proteomes:UP000008520}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Lg2 {ECO:0000313|EMBL:BAK60760.1,
RC   ECO:0000313|Proteomes:UP000008520};
RX   PubMed=21829716; DOI=10.1371/journal.pone.0023184;
RA   Morita H., Toh H., Oshima K., Yoshizaki M., Kawanishi M., Nakaya K.,
RA   Suzuki T., Miyauchi E., Ishii Y., Tanabe S., Murakami M., Hattori M.;
RT   "Complete genome sequence and comparative analysis of the fish pathogen
RT   Lactococcus garvieae.";
RL   PLoS ONE 6:E23184-E23184(2011).
CC   -!- FUNCTION: Probably acts as a heme chaperone, transferring heme to an
CC       unknown acceptor. Binds one molecule of heme per monomer, possibly
CC       covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3
CC       cysteines and an exchangeable S-adenosyl-L-methionine.
CC       {ECO:0000256|RuleBase:RU364116}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU364116}.
CC   -!- SIMILARITY: Belongs to the anaerobic coproporphyrinogen-III oxidase
CC       family. HemW subfamily. {ECO:0000256|ARBA:ARBA00006100}.
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DR   EMBL; AP009333; BAK60760.1; -; Genomic_DNA.
DR   RefSeq; WP_014025039.1; NC_017490.1.
DR   AlphaFoldDB; F9VEK9; -.
DR   STRING; 420890.LCGL_1300; -.
DR   KEGG; lgv:LCGL_1300; -.
DR   PATRIC; fig|420890.5.peg.1288; -.
DR   eggNOG; COG0635; Bacteria.
DR   HOGENOM; CLU_027579_2_2_9; -.
DR   OMA; HIPWCVR; -.
DR   Proteomes; UP000008520; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004109; F:coproporphyrinogen oxidase activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006779; P:porphyrin-containing compound biosynthetic process; IEA:InterPro.
DR   CDD; cd01335; Radical_SAM; 1.
DR   Gene3D; 3.80.30.20; tm_1862 like domain; 1.
DR   InterPro; IPR034505; Coproporphyrinogen-III_oxidase.
DR   InterPro; IPR006638; Elp3/MiaA/NifB-like_rSAM.
DR   InterPro; IPR010723; HemN_C.
DR   InterPro; IPR004559; HemW-like.
DR   InterPro; IPR007197; rSAM.
DR   InterPro; IPR023404; rSAM_horseshoe.
DR   NCBIfam; TIGR00539; hemN_rel; 1.
DR   PANTHER; PTHR13932; COPROPORPHYRINIGEN III OXIDASE; 1.
DR   PANTHER; PTHR13932:SF5; HEME CHAPERONE-RELATED; 1.
DR   Pfam; PF06969; HemN_C; 1.
DR   Pfam; PF04055; Radical_SAM; 1.
DR   SFLD; SFLDG01065; anaerobic_coproporphyrinogen-I; 1.
DR   SFLD; SFLDG01082; B12-binding_domain_containing; 1.
DR   SFLD; SFLDF00562; HemN-like__clustered_with_heat; 1.
DR   SFLD; SFLDF00288; HemN-like__clustered_with_nucl; 1.
DR   SMART; SM00729; Elp3; 1.
DR   SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR   PROSITE; PS51918; RADICAL_SAM; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|RuleBase:RU364116};
KW   Chaperone {ECO:0000256|RuleBase:RU364116};
KW   Cytoplasm {ECO:0000256|RuleBase:RU364116};
KW   Heme {ECO:0000256|RuleBase:RU364116}; Iron {ECO:0000256|RuleBase:RU364116};
KW   Iron-sulfur {ECO:0000256|RuleBase:RU364116};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU364116};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008520};
KW   S-adenosyl-L-methionine {ECO:0000256|RuleBase:RU364116}.
FT   DOMAIN          1..233
FT                   /note="Radical SAM core"
FT                   /evidence="ECO:0000259|PROSITE:PS51918"
SQ   SEQUENCE   374 AA;  43222 MW;  A2079A0C1820D8E6 CRC64;
     MKNNETKAAY VHIPFCSHIC YYCDFAKVLM TGQPVEAYID ELLKEYDSYG ISSLQTLYIG
     GGTPSVLPAD QLEKLLTHLT KNLDLEELEE FTVEANPSDL TDEVLAVLAQ SPVNRISLGV
     QSFDDKLLKK IGRTHTEAQV YSSIERLRAA GFENITIDLI YGLPNQTMEM VERDVQKFLE
     LDLPHVALYS LILEDHTVFM NRQRRGRLRL PSDDRNADMY EYIIETLTAK GYSHYEVSNF
     GKIGYESKHN MTYWDNAEYY GVGAGASGYL EGIRYKNHGP VHHYLREENK RVNEEVLTRK
     QRIEEEMFLG LRKKNGVSIE RFHKKFGQTL EEIYGTIIEE LTFQKMLFEA DGRIRMTEKG
     FELGNEVFER FLLD
//
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