ID   F9VEY9_LACGL            Unreviewed;       553 AA.
AC   F9VEY9;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   27-MAR-2024, entry version 54.
DE   RecName: Full=NADH oxidase {ECO:0000256|ARBA:ARBA00039201};
DE            EC=1.6.3.4 {ECO:0000256|ARBA:ARBA00039092};
GN   OrderedLocusNames=LCGL_1430 {ECO:0000313|EMBL:BAK60890.1};
OS   Lactococcus garvieae (strain Lg2) (Enterococcus seriolicida).
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus.
OX   NCBI_TaxID=420890 {ECO:0000313|EMBL:BAK60890.1, ECO:0000313|Proteomes:UP000008520};
RN   [1] {ECO:0000313|EMBL:BAK60890.1, ECO:0000313|Proteomes:UP000008520}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Lg2 {ECO:0000313|EMBL:BAK60890.1,
RC   ECO:0000313|Proteomes:UP000008520};
RX   PubMed=21829716; DOI=10.1371/journal.pone.0023184;
RA   Morita H., Toh H., Oshima K., Yoshizaki M., Kawanishi M., Nakaya K.,
RA   Suzuki T., Miyauchi E., Ishii Y., Tanabe S., Murakami M., Hattori M.;
RT   "Complete genome sequence and comparative analysis of the fish pathogen
RT   Lactococcus garvieae.";
RL   PLoS ONE 6:E23184-E23184(2011).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 H(+) + 2 NADH + O2 = 2 H2O + 2 NAD(+); Xref=Rhea:RHEA:37799,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.6.3.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00036014};
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|ARBA:ARBA00001974};
CC   -!- SIMILARITY: Belongs to the class-III pyridine nucleotide-disulfide
CC       oxidoreductase family. {ECO:0000256|ARBA:ARBA00009130}.
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DR   EMBL; AP009333; BAK60890.1; -; Genomic_DNA.
DR   RefSeq; WP_014025148.1; NC_017490.1.
DR   AlphaFoldDB; F9VEY9; -.
DR   STRING; 420890.LCGL_1430; -.
DR   KEGG; lgv:LCGL_1430; -.
DR   PATRIC; fig|420890.5.peg.1412; -.
DR   eggNOG; COG0446; Bacteria.
DR   eggNOG; COG0607; Bacteria.
DR   HOGENOM; CLU_003291_1_2_9; -.
DR   Proteomes; UP000008520; Chromosome.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR   Gene3D; 3.40.250.10; Rhodanese-like domain; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR023753; FAD/NAD-binding_dom.
DR   InterPro; IPR016156; FAD/NAD-linked_Rdtase_dimer_sf.
DR   InterPro; IPR004099; Pyr_nucl-diS_OxRdtase_dimer.
DR   InterPro; IPR001763; Rhodanese-like_dom.
DR   InterPro; IPR036873; Rhodanese-like_dom_sf.
DR   PANTHER; PTHR43429:SF1; COENZYME A DISULFIDE REDUCTASE; 1.
DR   PANTHER; PTHR43429; PYRIDINE NUCLEOTIDE-DISULFIDE OXIDOREDUCTASE DOMAIN-CONTAINING; 1.
DR   Pfam; PF07992; Pyr_redox_2; 1.
DR   Pfam; PF02852; Pyr_redox_dim; 1.
DR   Pfam; PF00581; Rhodanese; 1.
DR   PRINTS; PR00368; FADPNR.
DR   PRINTS; PR00411; PNDRDTASEI.
DR   SMART; SM00450; RHOD; 1.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR   SUPFAM; SSF55424; FAD/NAD-linked reductases, dimerisation (C-terminal) domain; 1.
DR   SUPFAM; SSF52821; Rhodanese/Cell cycle control phosphatase; 1.
DR   PROSITE; PS50206; RHODANESE_3; 1.
PE   3: Inferred from homology;
KW   Oxidation {ECO:0000256|ARBA:ARBA00023097};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008520}.
FT   DOMAIN          465..553
FT                   /note="Rhodanese"
FT                   /evidence="ECO:0000259|PROSITE:PS50206"
SQ   SEQUENCE   553 AA;  60511 MW;  5635A5E18687630B CRC64;
     MKIIIIGSVA SGTSVAAKAR RNTESAKITL YDKDTDISYA VCGIPYAIGG EIADFEELTP
     RDAKWFKKRY NVDIHTSHEV LSINHSTKTV TVKNLLSGEV FEDNYDILVF ATGATYRTPD
     VFSGKHFENV FQVRNINSGK EIKSFIENKK PMTAAVIGAG YIGLEVAEQL KERGIEVTIL
     QRGKHPMSHL DWDMSIRIED EMIKQGIDFR PEETIQTLIG ETQLDEAITS KGTKLSADMY
     ILATGVQPNV SLAQSIGVNI GETGAIATDN TLQTNIPGVY AVGDAAESFH VITGKPTYRP
     LASTANKMGR IAGDAMTGGP LRFQGILGTG ILRFFDLTIA QTGLTEKEAL AEGYEVAVLF
     NIKPDKPDYM HGKEMVIKAV ADKLTHRILG VQIIGSQGVD KRIDVFASTI TLGVTAEDLF
     HMDLAYAPPF STTKDPVAYT GMALTNALTT APLITPHDLM ELQKNNENIT IIDTRATKSY
     DKNHVPNAIN IPLAELREKA STLDKNKKTI VYCNKGVTGN ASQNVLRNEG FKEVYNLSGG
     NKNYQELAKK QQN
//