ID F9W706_TRYCI Unreviewed; 753 AA.
AC F9W706;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=adenylate cyclase {ECO:0000256|ARBA:ARBA00012201};
DE EC=4.6.1.1 {ECO:0000256|ARBA:ARBA00012201};
DE Flags: Fragment;
GN ORFNames=TCIL3000_0_37830 {ECO:0000313|EMBL:CCD12964.1};
OS Trypanosoma congolense (strain IL3000).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Nannomonas.
OX NCBI_TaxID=1068625 {ECO:0000313|EMBL:CCD12964.1, ECO:0000313|Proteomes:UP000000702};
RN [1] {ECO:0000313|Proteomes:UP000000702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IL3000 {ECO:0000313|Proteomes:UP000000702};
RA Jackson A.P., Berry A., Allison H.C., Burton P., Anderson J., Aslett M.,
RA Brown R., Corton N., Harris D., Hauser H., Gamble J., Gilderthorp R.,
RA McQuillan J., Quail M.A., Sanders M., Van Tonder A., Ginger M.L.,
RA Donelson J.E., Field M.C., Barry J.D., Berriman M., Hertz-Fowler C.;
RT "Divergent evolution of antigenic variation in African trypanosomes.";
RL Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CCD12964.1, ECO:0000313|Proteomes:UP000000702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IL3000 {ECO:0000313|EMBL:CCD12964.1,
RC ECO:0000313|Proteomes:UP000000702};
RX PubMed=22331916; DOI=10.1073/pnas.1117313109;
RA Jackson A.P., Berry A., Aslett M., Allison H.C., Burton P.,
RA Vavrova-Anderson J., Brown R., Browne H., Corton N., Hauser H., Gamble J.,
RA Gilderthorp R., Marcello L., McQuillan J., Otto T.D., Quail M.A.,
RA Sanders M.J., van Tonder A., Ginger M.L., Field M.C., Barry J.D.,
RA Hertz-Fowler C., Berriman M.;
RT "Antigenic diversity is generated by distinct evolutionary mechanisms in
RT African trypanosome species.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:3416-3421(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP = 3',5'-cyclic AMP + diphosphate; Xref=Rhea:RHEA:15389,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58165; EC=4.6.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001593};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-3 family.
CC {ECO:0000256|ARBA:ARBA00005381}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCD12964.1}.
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DR EMBL; CAEQ01000959; CCD12964.1; -; Genomic_DNA.
DR AlphaFoldDB; F9W706; -.
DR VEuPathDB; TriTrypDB:TcIL3000_0_37830; -.
DR OMA; RANEEDN; -.
DR OrthoDB; 66776at2759; -.
DR Proteomes; UP000000702; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 3.40.50.2300; -; 2.
DR InterPro; IPR028081; Leu-bd.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR PANTHER; PTHR43081:SF1; PH-SENSITIVE ADENYLATE CYCLASE RV1264; 1.
DR Pfam; PF13458; Peripla_BP_6; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000000702};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 117..417
FT /note="Leucine-binding protein"
FT /evidence="ECO:0000259|Pfam:PF13458"
FT NON_TER 753
FT /evidence="ECO:0000313|EMBL:CCD12964.1"
SQ SEQUENCE 753 AA; 82825 MW; 89EF3831D55AEE85 CRC64;
MAFVVHLAGA IGGSPRSLRA GNSVLSVTRR HRPLLVALML PLALALLSLT TPARAQGNVT
VKVYSLLFDH RANEEDNEAM NAGFNASMAS RQWMAAPDVN VELIYPPSYS VPNEEVLRSV
VEQNKGELII ILGPISDASV TRSRELLRKE GLVAFGPVAG SSAVRGWDPN IYFIQTSPAA
ELLALLRYAV SRLRLRRLGF MYLQGTSFGD GDYKQAVELM SHMGLQLCGV FTKNRSSPFT
GVDNVFENVW EQFAATLPQG VLLFAPPIED TVAFIRRMVA DNRTRKSFLL APSVLEIVIA
NEWSEALAAV GAPLVPGQVL LTGTNPLATD TEYHAIKRFQ RDARAYLRDN PGVTVFNATD
DFDHDDIDGA LMVYGWIAGE VLAQALSGRQ WLRSREAFME SLYNQRRYVI DDLVIGDFGG
NCKGDAGKHG AVCQCNQGGN AVYMKALVEN YRFVTLQNGE VYFASSHCYS DDIRLDAPLS
GLLFYVWDDE TTEEAIISFA YGMMGATEST EMQRLDRFFF HALATSAAEG SLTLRRELDT
RIVTAVFGIV DDAMLATPDV TFVDPITVTP HLHSSARNVI HLSPTLEQQL FVTVGYIVNS
SGAGTFHAAI RGNDTHVIED MVRKTAVTFD RSLGTVATLH DHTSATDIMP HEGDVLLIGL
TPSDPLEVAK HLDSYTSVRV FVPFFDVALL YDEFVRAFRN RSSAARLLFA TSLPHWAEEG
PLSETVRGFH NMVPDRTKWT PLALLGFATA RAM
//
