ID F9W7M6_TRYCI Unreviewed; 665 AA.
AC F9W7M6;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=WGS project CAEQ00000000 data, annotated contig 1631 {ECO:0000313|EMBL:CCD13197.1};
GN ORFNames=TCIL3000_0_39680 {ECO:0000313|EMBL:CCD13197.1};
OS Trypanosoma congolense (strain IL3000).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Nannomonas.
OX NCBI_TaxID=1068625 {ECO:0000313|EMBL:CCD13197.1, ECO:0000313|Proteomes:UP000000702};
RN [1] {ECO:0000313|Proteomes:UP000000702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IL3000 {ECO:0000313|Proteomes:UP000000702};
RA Jackson A.P., Berry A., Allison H.C., Burton P., Anderson J., Aslett M.,
RA Brown R., Corton N., Harris D., Hauser H., Gamble J., Gilderthorp R.,
RA McQuillan J., Quail M.A., Sanders M., Van Tonder A., Ginger M.L.,
RA Donelson J.E., Field M.C., Barry J.D., Berriman M., Hertz-Fowler C.;
RT "Divergent evolution of antigenic variation in African trypanosomes.";
RL Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CCD13197.1, ECO:0000313|Proteomes:UP000000702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IL3000 {ECO:0000313|EMBL:CCD13197.1,
RC ECO:0000313|Proteomes:UP000000702};
RX PubMed=22331916; DOI=10.1073/pnas.1117313109;
RA Jackson A.P., Berry A., Aslett M., Allison H.C., Burton P.,
RA Vavrova-Anderson J., Brown R., Browne H., Corton N., Hauser H., Gamble J.,
RA Gilderthorp R., Marcello L., McQuillan J., Otto T.D., Quail M.A.,
RA Sanders M.J., van Tonder A., Ginger M.L., Field M.C., Barry J.D.,
RA Hertz-Fowler C., Berriman M.;
RT "Antigenic diversity is generated by distinct evolutionary mechanisms in
RT African trypanosome species.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:3416-3421(2012).
CC -!- SIMILARITY: Belongs to the retroviral Pol polyprotein family.
CC {ECO:0000256|ARBA:ARBA00009555}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCD13197.1}.
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DR EMBL; CAEQ01001054; CCD13197.1; -; Genomic_DNA.
DR AlphaFoldDB; F9W7M6; -.
DR VEuPathDB; TriTrypDB:TcIL3000_0_39680; -.
DR OrthoDB; 5052374at2759; -.
DR Proteomes; UP000000702; Unassembled WGS sequence.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:InterPro.
DR GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR CDD; cd09273; RNase_HI_RT_Bel; 1.
DR Gene3D; 1.10.340.70; -; 1.
DR Gene3D; 2.30.30.850; -; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 2.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR040643; MLVIN_C.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR002156; RNaseH_domain.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR015416; Znf_H2C2_histone_UAS-bd.
DR PANTHER; PTHR41694; ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN; 1.
DR PANTHER; PTHR41694:SF5; RIBONUCLEASE H; 1.
DR Pfam; PF18697; MLVIN_C; 1.
DR Pfam; PF00075; RNase_H; 1.
DR Pfam; PF00665; rve; 1.
DR Pfam; PF09337; zf-H2C2; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 2.
DR PROSITE; PS50994; INTEGRASE; 1.
DR PROSITE; PS50879; RNASE_H_1; 1.
PE 3: Inferred from homology;
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000000702};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 109..255
FT /note="RNase H type-1"
FT /evidence="ECO:0000259|PROSITE:PS50879"
FT DOMAIN 365..523
FT /note="Integrase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50994"
SQ SEQUENCE 665 AA; 74028 MW; 2FE3EF8741C02012 CRC64;
MAYMSESYAA VALLIKDADK LTMGQQVTVV APHALESIVR QPPDRWMTNA RMTHYQSLLL
NEHVTFAPPA ILNPATLLPL TNDSVPVHQC MDILAEEPGT RSDLTDQPWP GAPSWYTDGS
SFLIEGKRKA GAAVVDGKKV IWASALPEGT SAQKAELIAL IQALREAKGK IINIYTDSRY
AFATTHIHGA IYRQRGLLTS AGKDIKNKEE ILALLEAIHA PKKVAIIHCP SHQRGEDLVA
RGNRMADSVA KQVAQGAMIL TEKGDPPKST EDERYNIKEL WWTRDPFPYF FEGKIELTPK
EGIKFVKGLH QFTHLGVEKM MRLIKNSRYQ VPNLKSVAQK VIDSCKPCAF TNATKAYREP
GKRQRGDHPG VYWEVDFTEV KPGMYGNKYL LVFVDTFSGW VEAFPTKTET AQIVAKKILE
EILPRFGIPK VIGSDNGPAF VAQVSQGLAT QLGINWKLHC AYRPQSSGQV ERMNRTLKET
LTKLAIETGG KDWVALLPLA LFRARNTPGR FGLTPFEVLY GGPPPLIEAG GTLVSDSDPV
LPSSLLIHLK ALEVIRTQIW DQLKAAYTPG TTAVPHGFRV GDKVLVRRHR TGSLEPRWKG
PYLVLLTTPT AVKVDGIASW IHASHVKRIT SQDEENHDDN WTVAATDNPL KLRLRRRRHS
RLRES
//
