ID F9WGM4_TRYCI Unreviewed; 797 AA.
AC F9WGM4;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=WGS project CAEQ00000000 data, annotated contig 518 {ECO:0000313|EMBL:CCD16461.1};
DE Flags: Fragment;
GN ORFNames=TCIL3000_0_13810 {ECO:0000313|EMBL:CCD16461.1};
OS Trypanosoma congolense (strain IL3000).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Nannomonas.
OX NCBI_TaxID=1068625 {ECO:0000313|EMBL:CCD16461.1, ECO:0000313|Proteomes:UP000000702};
RN [1] {ECO:0000313|Proteomes:UP000000702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IL3000 {ECO:0000313|Proteomes:UP000000702};
RA Jackson A.P., Berry A., Allison H.C., Burton P., Anderson J., Aslett M.,
RA Brown R., Corton N., Harris D., Hauser H., Gamble J., Gilderthorp R.,
RA McQuillan J., Quail M.A., Sanders M., Van Tonder A., Ginger M.L.,
RA Donelson J.E., Field M.C., Barry J.D., Berriman M., Hertz-Fowler C.;
RT "Divergent evolution of antigenic variation in African trypanosomes.";
RL Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CCD16461.1, ECO:0000313|Proteomes:UP000000702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IL3000 {ECO:0000313|EMBL:CCD16461.1,
RC ECO:0000313|Proteomes:UP000000702};
RX PubMed=22331916; DOI=10.1073/pnas.1117313109;
RA Jackson A.P., Berry A., Aslett M., Allison H.C., Burton P.,
RA Vavrova-Anderson J., Brown R., Browne H., Corton N., Hauser H., Gamble J.,
RA Gilderthorp R., Marcello L., McQuillan J., Otto T.D., Quail M.A.,
RA Sanders M.J., van Tonder A., Ginger M.L., Field M.C., Barry J.D.,
RA Hertz-Fowler C., Berriman M.;
RT "Antigenic diversity is generated by distinct evolutionary mechanisms in
RT African trypanosome species.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:3416-3421(2012).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCD16461.1}.
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DR EMBL; CAEQ01002291; CCD16461.1; -; Genomic_DNA.
DR AlphaFoldDB; F9WGM4; -.
DR VEuPathDB; TriTrypDB:TcIL3000_0_13810; -.
DR OMA; TEECELC; -.
DR OrthoDB; 2169464at2759; -.
DR Proteomes; UP000000702; Unassembled WGS sequence.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:InterPro.
DR CDD; cd09276; Rnase_HI_RT_non_LTR; 1.
DR CDD; cd01650; RT_nLTR_like; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR002156; RNaseH_domain.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR19446:SF415; REVERSE TRANSCRIPTASE-RELATED PROTEIN; 1.
DR PANTHER; PTHR19446; REVERSE TRANSCRIPTASES; 1.
DR Pfam; PF00075; RNase_H; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SMART; SM00355; ZnF_C2H2; 2.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50879; RNASE_H_1; 1.
DR PROSITE; PS50878; RT_POL; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Reference proteome {ECO:0000313|Proteomes:UP000000702};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT DOMAIN 1..240
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT DOMAIN 441..582
FT /note="RNase H type-1"
FT /evidence="ECO:0000259|PROSITE:PS50879"
FT DOMAIN 760..782
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT NON_TER 797
FT /evidence="ECO:0000313|EMBL:CCD16461.1"
SQ SEQUENCE 797 AA; 89053 MW; DDCFDA9F257A7D82 CRC64;
MASFRPVTLT STLCKLMERI VARRVRDCIE DKLQPQQAGF RPARSTLDTL MQVTSAVRRR
RDGEKTAAVF IDYARAFDSV DHNCIVKALM SFGVEEHLVA WIADFLQGRT AQVRVNNTLS
EDISLTCGVP QGSVLGPLLF IVTVDSLSKR LNCIPGLQHG FFADDLTIVC TSADLSAIQQ
TIQQGLDCIT RWSEEHYMEV SAEKTEYTLF GARETNLLSL KVGETVLKEV RTPKLLGLTM
QPHKGLSKHV QGVKAAADAR LLQLRAVASP EWGPDREKLR AFYLALVQAK VCYGIASWWF
DTSLSDRERL EKVQAQAAHI VAGIPKAANR NDALCEARLK PINEVAHRRA LEYYLRLKAK
GAVHAKIAES IFPPEHPIHV RLAKVKHLYS TIDGTGKQHD ATVLQLARRV HFNTTTPGGL
KADAPEKDKK MHTMRRVVRF REFDYQVWTD GSVVLDVSSG AGALVYPKEG RREKVVLGAG
SLACSYRAEC VAMEAGLKRL VDVIELNQTH RTRVVAFTDS LSLLMALSTG PAVVEDAILR
RIWDLILRLV RLRVSVNFQF VFSHCGVPRN EAADKAAEQG NAKPQMYPAW VTDIVTGVER
QVRNEMYLSF EEGRMQRTHR SVLLDHVRPA PKHTKLDRPG ESLLAQFRTG TSKHFGWLHR
VLTRKTDRLE CRWCRAKDIG GNAVEGHTLA ESAVDSANAP DFGIATRQSD PIICPLCNMV
CARRQAGVVH LVKIHGLKRE CALAMTKKAR RAALTYKNGY TCHVCGDAFE RRGLLVEHMA
QHPPVVVPTV EERPKRH
//
