ID F9WK14_TRYCI Unreviewed; 947 AA.
AC F9WK14;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=WGS project CAEQ00000000 data, annotated contig 97 {ECO:0000313|EMBL:CCD17675.1};
GN ORFNames=TCIL3000_0_02690 {ECO:0000313|EMBL:CCD17675.1};
OS Trypanosoma congolense (strain IL3000).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Nannomonas.
OX NCBI_TaxID=1068625 {ECO:0000313|EMBL:CCD17675.1, ECO:0000313|Proteomes:UP000000702};
RN [1] {ECO:0000313|Proteomes:UP000000702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IL3000 {ECO:0000313|Proteomes:UP000000702};
RA Jackson A.P., Berry A., Allison H.C., Burton P., Anderson J., Aslett M.,
RA Brown R., Corton N., Harris D., Hauser H., Gamble J., Gilderthorp R.,
RA McQuillan J., Quail M.A., Sanders M., Van Tonder A., Ginger M.L.,
RA Donelson J.E., Field M.C., Barry J.D., Berriman M., Hertz-Fowler C.;
RT "Divergent evolution of antigenic variation in African trypanosomes.";
RL Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CCD17675.1, ECO:0000313|Proteomes:UP000000702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IL3000 {ECO:0000313|EMBL:CCD17675.1,
RC ECO:0000313|Proteomes:UP000000702};
RX PubMed=22331916; DOI=10.1073/pnas.1117313109;
RA Jackson A.P., Berry A., Aslett M., Allison H.C., Burton P.,
RA Vavrova-Anderson J., Brown R., Browne H., Corton N., Hauser H., Gamble J.,
RA Gilderthorp R., Marcello L., McQuillan J., Otto T.D., Quail M.A.,
RA Sanders M.J., van Tonder A., Ginger M.L., Field M.C., Barry J.D.,
RA Hertz-Fowler C., Berriman M.;
RT "Antigenic diversity is generated by distinct evolutionary mechanisms in
RT African trypanosome species.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:3416-3421(2012).
CC -!- SIMILARITY: Belongs to the cullin family. {ECO:0000256|PROSITE-
CC ProRule:PRU00330, ECO:0000256|RuleBase:RU003829}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCD17675.1}.
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DR EMBL; CAEQ01002798; CCD17675.1; -; Genomic_DNA.
DR AlphaFoldDB; F9WK14; -.
DR VEuPathDB; TriTrypDB:TcIL3000_0_02690; -.
DR OrthoDB; 123594at2759; -.
DR Proteomes; UP000000702; Unassembled WGS sequence.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR045093; Cullin.
DR InterPro; IPR016158; Cullin_homology.
DR InterPro; IPR036317; Cullin_homology_sf.
DR InterPro; IPR001373; Cullin_N.
DR InterPro; IPR019559; Cullin_neddylation_domain.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11932; CULLIN; 1.
DR PANTHER; PTHR11932:SF126; CULLIN 4, ISOFORM A; 1.
DR Pfam; PF00888; Cullin; 1.
DR Pfam; PF10557; Cullin_Nedd8; 1.
DR SMART; SM00884; Cullin_Nedd8; 1.
DR SUPFAM; SSF75632; Cullin homology domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50069; CULLIN_2; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000000702}.
FT DOMAIN 542..733
FT /note="Cullin family profile"
FT /evidence="ECO:0000259|PROSITE:PS50069"
SQ SEQUENCE 947 AA; 106927 MW; 706DBCBE9200A4E1 CRC64;
MDHVNSATTA DAHFIGTSLA DRLREAYRAL EIHQPPQFLS PALRDLFEVT LNTEILLKPR
GAGGLLKQRQ ERLQWYNEIY SGLRGVYNTS ALLRYWVAGI VNYQLREVRR CVDAAQENTT
DSAVKNVQMF EAIQHALELR DVLRRLPVLV SFLFAWDVEL SDVERFDSLL KEVIAVNFSM
ESVREVLLHL LAEYMRPQRR MQNDKVQGSA ELTRHQRQCK PGDVLIALCE LIQLFVGDRR
TVEERVTVVI LQGVVESCNE KFKQRTLLDL LQPDEASAKA RREFVVDTWL RYWNSELELV
RVIDFVDEAW VKGILLKLIF LWDPCDVSVD AEGDVRGAPV NLSCTYLHKL LHLTLEPVFG
DIFGTQRLAD AGVTTAEAGK QQAGLGLHGV NRIGVEEDLL EFLLQVANAM ACAEAPPWRD
IRCWESVGVV PSLPPGVARD VGPQVLADVC RILLQEQLPR AVSSFLCGSE PDERQRWRLL
QFLICVEKMF DRLCSVRGLN VRLLDARSST GGVGHGGRGC FYSIVETALL RGEHGQREVN
IFVDELLNVI HGFLLDKERA VLATAKSGRN HETVLNNHED LRSAIRMAYH LSPRGALIPL
YKRLLAYRLL SLNYLRQHDT AVAQLNRERL KQEESVCLYL LELIPGDRDA IQQMMQMCCD
IDTSANMQEV FDQRQGRDAA GSSVKFAVKV LSRHAWPAYP VLTTAPSSLK GAMSNFSAAY
EELHPSRRIV WLRTAFECVT FNVAYPRGKK TITGSLDLFM AFEYLSEVSA ALDGNGGGAS
WDDVGRRVGK HYTDLQQELR KLLSDGFIAI IPAPTGAAGT EKTDLTSSEP PRWICLNPEF
ASHQTHFTFL AKQQRRHLRP ATRSKQEAGV SDETHGSRVT ATQAAIVSHM KALKCCCYDE
LFRLTQQSVQ RHFQLQTSDF KPILEHLIEK GLIERDETKK GQFIYIA
//
