ID F9WNJ4_TRYVY Unreviewed; 664 AA.
AC F9WNJ4;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 03-MAY-2023, entry version 57.
DE RecName: Full=Kinesin-like protein {ECO:0000256|RuleBase:RU000394};
GN ORFNames=TvY486_0018200 {ECO:0000313|EMBL:CCD19112.1};
OS Trypanosoma vivax (strain Y486).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Duttonella.
OX NCBI_TaxID=1055687 {ECO:0000313|EMBL:CCD19112.1, ECO:0000313|Proteomes:UP000009027};
RN [1] {ECO:0000313|EMBL:CCD19112.1, ECO:0000313|Proteomes:UP000009027}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Y486 {ECO:0000313|EMBL:CCD19112.1,
RC ECO:0000313|Proteomes:UP000009027};
RX PubMed=22331916; DOI=10.1073/pnas.1117313109;
RA Jackson A.P., Berry A., Aslett M., Allison H.C., Burton P.,
RA Vavrova-Anderson J., Brown R., Browne H., Corton N., Hauser H., Gamble J.,
RA Gilderthorp R., Marcello L., McQuillan J., Otto T.D., Quail M.A.,
RA Sanders M.J., van Tonder A., Ginger M.L., Field M.C., Barry J.D.,
RA Hertz-Fowler C., Berriman M.;
RT "Antigenic diversity is generated by distinct evolutionary mechanisms in
RT African trypanosome species.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:3416-3421(2012).
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283,
CC ECO:0000256|RuleBase:RU000394}.
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DR EMBL; CAEX01002639; CCD19112.1; -; Genomic_DNA.
DR AlphaFoldDB; F9WNJ4; -.
DR VEuPathDB; TriTrypDB:TvY486_0018200; -.
DR OMA; CAIMRTR; -.
DR OrthoDB; 152933at2759; -.
DR Proteomes; UP000009027; Unassembled WGS sequence.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd01367; KISc_KIF2_like; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR InterPro; IPR027640; Kinesin-like_fam.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR47971:SF16; KINESIN-LIKE PROTEIN; 1.
DR PANTHER; PTHR47971; KINESIN-RELATED PROTEIN 6; 1.
DR Pfam; PF00225; Kinesin; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00283,
KW ECO:0000256|RuleBase:RU000394};
KW Microtubule {ECO:0000256|RuleBase:RU000394};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283,
KW ECO:0000256|RuleBase:RU000394};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00283,
KW ECO:0000256|RuleBase:RU000394};
KW Reference proteome {ECO:0000313|Proteomes:UP000009027}.
FT DOMAIN 127..443
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 488..522
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 214..221
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 664 AA; 72708 MW; A65A5AF545D6944C CRC64;
MPIIPNIASQ QQHVQSNENL PHAPPLAKQP LPHIPNMLSG RSVASPVLAK VHSPTHQVDE
FPSVSPRPLK IPRAASPDTK YAGVAAGTCS PKISDGHSFS CLAAEEVNAQ CEPKTGPPLT
GRTRGGRIKV VIRKRPLPPD DNSGSDCVSI DPPCVHIAMR KQRVDLTEYA DINDFTFDDA
FAEDKCNEYL FNSCCKELLD TTLQGGSASC FAYGQTGSGK THTMLGNSEE RGLYVLAAAS
IFSSLEENQE VYASLYEIYC NSLFDLLNNR TPVVVREDHK RRMHISGLTW HAVSSAELLQ
QLINNGADRR STGSTTANER SSRSHAVLTI QVRHQDDPKF CGTLNMVDLA GSERAADTAT
TDRQTRQEGA EINKSLLALK ECIRALDEKK KHVPFRGSKL TEILRDSFIG NSRTVMIANI
SASSQNYEHT LNTLRYAFRV KGLSVATFEP SRARNAPRPA RPVAADVPQL QLPVAFAAAA
CPGNVGGAVG ARNTPARKRT VSAPAPAGPN RQQGAGAAGQ NKRQGIFSNA VQNPNPKASD
SCGDCFRALT REKILSFVPN IKIPDRDEEP VSSHRDALEG DVQANPFTQQ QLRDLEDRVM
AQLRTDMEYN VKQTLLRRDR TLQRLRRENA ALHITVAALE KRAAECPYCR GKQCNRANDN
VEMQ
//
